Protein Alignment Mlh1 and MLH3

DIOPT Version :10

• Sequence 1: NP_477022.1
• Gene: Mlh1 / 35796
• FlyBaseID: FBgn0011659
• Length: 664
• Species: Drosophila melanogaster
• Sequence 2: NP_001328252.1
• Gene: MLH3 / 829704
• AraportID: AT4G35520
• Length: 1180
• Species: Arabidopsis thaliana
• Alignment Length: 538
• Identity: 118/538 - (21%)
• Similarity: 221/538 - (41%)
• Gaps: 80/538 - (14%)

  Fly    10 IRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNGTGIRRED 74
            |:.|.|.|.:.:.:|.|:...|..::||:.|||||.:|.:.:.|...... :::.|:|:|:.|:|
plant     4 IKPLPEGVRHSMRSGIIMFDMARVVEELVFNSLDAGATKVSIFVGVVSCS-VKVVDDGSGVSRDD 67

  Fly    75 LAIVCERFTTSKLTRFEDLSQI----ATFGFRGEALASISHVAHLSIQTKTAKEKCGYKATYADG 135
            |.::.||:.|||   |.|.:.:    .|||||||||||||.::.|.::||......||:......
plant    68 LVLLGERYATSK---FHDFTNVETASETFGFRGEALASISDISLLEVRTKAIGRPNGYRKVMKGS 129

  Fly   136 K-----LQGQPKPCAGNQGTIICIEDLFYNMPQRRQALR-SPAEEFQRLSEVLARYAVHNPRVGF 194
            |     :....|    :.||.:.:.||||:.|.||:.:: ||.:..:.:.:.:.|.|:.:..|.|
plant   130 KCLHLGIDDDRK----DSGTTVTVRDLFYSQPVRRKYMQSSPKKVLESIKKCVFRIALVHSNVSF 190

  Fly   195 TLRKQGDAQPALRTPVASSRSENIRIIYGAAISKELLEFSHRDEVYKFEAECLITQVNYSAKKCQ 259
            ::......:...:|..:||....:....|......|.:.:..|.:.....  .::....|.|..|
plant   191 SVLDIESDEELFQTNPSSSAFSLLMRDAGTEAVNSLCKVNVTDGMLNVSG--YVSGPGDSLKALQ 253

  Fly   260 MLLFINQRLVESTALRTSVDSIYATY------LPRG-----------HHPFVYMSLTLPPQNLDV 307
             .::||.|.:....:...::::..::      .|..           .:|...:.:..|.:..:.
plant   254 -YIYINSRFISKGPIHKLLNNLATSFECADDWKPTDGQQTGRRNRLQSNPGYILCIACPRRLYEF 317

  Fly   308 NVHPTKHEVHFLYQEEIVDSIKQQVEARLLGSNATRTFYKQLRL----PGAPDL----DETQLAD 364
            :..|:|..|.|.....::..|::          .|...:|:.|:    .|..|:    |...|.|
plant   318 SFEPSKTHVEFKKWGPVLAFIER----------ITLANWKKDRILELFDGGADILAKGDRQDLID 372

  Fly   365 ---KTQRIYPKEMVRTDSTEQKLDK-----------FLAPLVKSDSGVSSSSSQEASRLPEESFR 415
               :.|..:|:.|   :..::||.:           |.:...|.|....|......|...|...:
plant   373 DKIRLQNDWPEAM---EPAKKKLKRSNDHAPCSSLLFPSADFKQDGDYFSPRKDVWSPECEVELK 434

  Fly   416 VTAAKKSR-----EVRLSSVLDMRKRVERQCSVQLRSTLKNLVYVGCVDERRALFQHETRLYMCN 475
            :...|:..     |.|..|:|..|. :|.|.:... ..:.:|:....|.:.:...|..||..:..
plant   435 IQNPKEQGTVAGFESRTDSLLQSRD-IEMQTNEDF-PQVTDLLETSLVADSKCRKQFLTRCQITT 497

  Fly   476 TRSFSEELFYQRMIYEFQ 493
            ..:.:.:......:..||
plant   498 PVNINHDFMKDSDVLNFQ 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mlh1	NP_477022.1	mutl	8..317	CDD:273155	81/333 (24%)
		Mlh1_C	426..664	CDD:465109	13/68 (19%)
MLH3	NP_001328252.1	mutl	2..273	CDD:273155	76/279 (27%)
		TopoII_MutL_Trans	209..339	CDD:445919	17/132 (13%)
		MutL_C	948..1106	CDD:214857