Protein Alignment Mlh1 and Pms2

DIOPT Version :10

• Sequence 1: NP_477022.1
• Gene: Mlh1 / 35796
• FlyBaseID: FBgn0011659
• Length: 664
• Species: Drosophila melanogaster
• Sequence 2: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Alignment Length: 755
• Identity: 165/755 - (21%)
• Similarity: 310/755 - (41%)
• Gaps: 189/755 - (25%)

  Fly     8 GVIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNGTGIRR 72
            |.|:.:.:..|::|.:|:::...|.|:|||:|||:||.:|.:::::|..||:.:::.|||:|:..
  Fly    25 GQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEE 89

  Fly    73 EDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCGYKATY-ADGK 136
            .:|..:..::.|||:..|.||..:.|||||||||:|:..::.:.|||:......|.|... .:|:
  Fly    90 MNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGR 154

  Fly   137 LQGQPKPCAGNQGTIICIEDLFYNMP-QRRQALRSPAEEFQRLSEVLARYAV-----------HN 189
            :: :..|||...||.:.:.:||..:| :||...|:..:||.::.::|..|.:           |.
  Fly   155 IK-KRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSNHT 218

  Fly   190 PRVGFT--LRKQGDAQPALRTPVASSRSENIRIIYGAAISKELL--------------------- 231
            |:...|  |:..||.:.          ..||..|:||..:.:|:
  Fly   219 PKGAKTIVLQTHGDQEV----------MANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLE 273

  Fly   232 ---------------EFSHRDEVYKFEAECLITQVNYSA---KKCQMLLFINQRLVESTALRTSV 278
                           |...|.....|:.|..|:...:.|   .:.:...|:|.|..:...:...:
  Fly   274 SGADLADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVM 338

  Fly   279 DSIYATYLPRGHHPFVYMSLTLPPQNLDVNVHPTKHEVHFLYQEEIVDSIKQ-------QVEARL 336
            :.:|..|..: ..||:|:::.....::|||:.|.|.::....:..::.::|:       |..|..
  Fly   339 NEVYHRYNVQ-QQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATF 402

  Fly   337 LGSNAT-------RTFYKQLRLPGAPDLDETQLADKTQRIYPKEMVRTDSTEQKLD--------- 385
            ...|.|       :|...:.:.|     .|:...|:.:.: .:|.|.|.||::.:|
  Fly   403 QMQNTTIVSMLEPKTNSGKTKFP-----KESSKDDQHEEV-SEEDVPTTSTQRFMDVLTQWRRTG 461

  Fly   386 --KFLAPLV-------KSDSGVS--------------SSSSQEASRLPEES---FRVTAAKKSR- 423
              |..||.|       :|:..|:              .|.::::|:...||   ..|..|||.:
  Fly   462 DTKGTAPSVPVKRRCSESEELVTRTLKMQKIHTFLSQESPNEQSSKCEAESDAASDVDMAKKDKT 526

  Fly   424 EVRL-SSVLDMRKRVERQCSVQLRSTLKNLVYVGC-----VDERRALFQHETRLYMCNTRSFSEE 482
            :|.| :|.|::::..:...:..|.:..:|...:.|     :..||::|:.:|.....:.:
  Fly   527 QVSLDNSFLNLKELAKESEAYDLLTKPQNTPRIDCKVLTPIKSRRSIFEFKTDAMALDKQ----- 586

  Fly   483 LFYQRMIYEFQNCSEITISPPLPLKELLILSLESEAAGWTPEDGDKAELADGAADILLKKAPIMR 547
                      ::.:|:...||    ....||.|::.|.   ::.|..||            |...
  Fly   587 ----------ESPAELNSQPP----SFTQLSEETDIAS---DEDDHIEL------------PTRI 622

  Fly   548 EYFGLRISEDGMLESLPSLL--------------------HQHRPCVAHLPVYLLRLATEVDWEQ 592
            |:      ::.|.|.|||..                    .|.|.......:..||..||::..|
  Fly   623 EF------DEEMEEGLPSNFSSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQ 681

  Fly   593 ETRCFETFCRETAR-FYAQLDWREGATAGFSRWTMEHVLF 631
            .|.......||..: .:|:::.......||....:|..||
  Fly   682 NTSAEAELQREIDKEDFARMEIIGQFNLGFIIVKLEDDLF 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mlh1	NP_477022.1	mutl	8..317	CDD:273155	92/362 (25%)
		Mlh1_C	426..664	CDD:465109	43/233 (18%)
Pms2	NP_477023.1	mutl	25..376	CDD:273155	92/362 (25%)
		mutL	33..880	CDD:234630	163/747 (22%)