DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mlh1 and Mlh3

DIOPT Version :10

Sequence 1:NP_477022.1 Gene:Mlh1 / 35796 FlyBaseID:FBgn0011659 Length:664 Species:Drosophila melanogaster
Sequence 2:NP_001101513.1 Gene:Mlh3 / 314320 RGDID:1309227 Length:1442 Species:Rattus norvegicus


Alignment Length:712 Identity:156/712 - (21%)
Similarity:281/712 - (39%) Gaps:155/712 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 VIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQ--DNGTGIR 71
            :||.|.:.|..::.:|..:......::||..||:||::|.:.::|   .::..|:|  |||.|:.
  Rat     1 MIRCLSDEVQAKLRSGLALSSLGQCVEELTLNSIDAEATCVAIRV---NMETFQVQVIDNGLGMA 62

  Fly    72 REDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAH-LSIQTKTAKEKCGYKATYADG 135
            .:|:..|..|:.|||.....||.....:||||||||||:.:|. :.|.:|.:.....:...:.:|
  Rat    63 GDDVEKVGNRYFTSKCHSVRDLENPTFYGFRGEALASIADMASAVEISSKKSTTLKTFVKMFQNG 127

  Fly   136 KLQGQ-----PKPCAGNQGTIICIEDLFYNMPQRRQALRSPAEEFQRLSEVLARYAVHNPRVGFT 195
            |....     .:|   :.||.:.:.:|||..|.||::: .|..||:::.:.:...::.:|.:.|:
  Rat   128 KALAAREADLTRP---SVGTTVTVYNLFYQFPVRRKSM-DPRLEFEKVRQRVEALSLMHPSISFS 188

  Fly   196 LRKQGDAQPALRTPVASSRSENIRIIYGAAISKELLEFSHRDEVYKFEAECLITQVNYSAKKCQM 260
            ||........|:.|...........|||...|::|.|..::.:.::|.. .:.::.:|:  |...
  Rat   189 LRNDVSGSMILQLPKTKDICSRFCQIYGLGKSQKLREIHYKYKEFEFNG-YISSEAHYN--KNMQ 250

  Fly   261 LLFINQRLVESTALRTSVD-----------------SIYATYLPRGH-----HPFVYMSLTLPPQ 303
            .||:|:|||..|.|...:|                 |......||..     |....:::..|..
  Rat   251 FLFVNRRLVLRTKLHKLIDFLLRKESIICRPKNGSASRQMNSSPRHRSASELHGIYVINVQCPFC 315

  Fly   304 NLDVNVHPTKHEVHFLYQEEIVDSIKQQVEARLLGSNATRTFYKQLRLPGAPDLDETQLADKTQR 368
            ..||.:.|.|..:.|...:.::..:::.:          :.|.||.:|       ..:|:.:..:
  Rat   316 EYDVCIEPAKTLIEFQNWDTVLICVQEGI----------KKFLKQEKL-------FVELSSEDIK 363

  Fly   369 IYPKE--------MVRTDSTEQKLDKFLAPLVKSDSGVSSSSSQEASRLPEESFRVTAAKKSREV 425
            .:.::        .::|.||.:|.|:              ||.|||.....:|:.:... :|:.|
  Rat   364 EFNEDNGFSLIGTTLQTQSTHEKCDQ--------------SSFQEACNNILDSYEMFNL-QSKAV 413

  Fly   426 RLSSVLD------------MRKRVERQCSVQ---------LRSTLKN--LVYVG--CVDERRALF 465
            :..:.|:            :||:.|...:.:         :.|.|.|  ..|:|  ..:|..|..
  Rat   414 KRIATLENRTTQNSGDSGAIRKKTEDSYTYESDDLGHRKTVESALYNSDSAYLGSRMSEEDIAKT 478

  Fly   466 QHETRLYMCNTRSFSEELFYQRMIYEFQNCSEITISPPL----PLKELLILSLESEAAGWTPEDG 526
            .|..     ....:.:.|...|........|....|.|:    ||:       ||||        
  Rat   479 SHAG-----ENEKWKKSLLENRTSERPHETSPKMFSSPIQTHHPLE-------ESEA-------- 523

  Fly   527 D-KAELADGAADILLKKAPIMREYFGLRISEDGMLESLPSLLHQHRPCVAHLPVYLLRLATEVDW 590
            | :.|:.....:::....|...|.    .|:...||..|.:..|..|    ....|||....:..
  Rat   524 DLEIEMKSSTVNVMAANIPPNSEI----QSQLEQLEDAPEVECQPLP----FETTLLRAQGTLKK 580

  Fly   591 EQETRCFETFCRETARFYAQLDWREGATAGFSRWTMEHVL--FPA--------FKKYLLPPP 642
            ::..:...:..|.....|.|:   :..:.||    :.||:  .||        ||.|..|.|
  Rat   581 KERKKELSSHGRVNVFSYGQV---KLCSTGF----ITHVVQREPAKSPETEQLFKNYARPGP 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mlh1NP_477022.1 mutl 8..317 CDD:273155 87/337 (26%)
Mlh1_C 426..664 CDD:465109 50/257 (19%)
Mlh3NP_001101513.1 HATPase_MutL-MLH-PMS-like 9..192 CDD:340403 55/189 (29%)
MutL_Trans_MLH3 206..349 CDD:239568 29/155 (19%)
MutL <1182..1397 CDD:440092
Blue background indicates that the domain is not in the aligned region.

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