DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gasz and FANK1

DIOPT Version :9

Sequence 1:	NP_610362.1	Gene:	Gasz / 35795	FlyBaseID:	FBgn0033273	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	XP_011538650.1	Gene:	FANK1 / 92565	HGNCID:	23527	Length:	381	Species:	Homo sapiens

Alignment Length:	276	Identity:	76/276 - (27%)
Similarity:	118/276 - (42%)	Gaps:	56/276 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YGPPPDSDSD--SSYDGFYFSDKVKRSKPAPYVDPEQKLYDAVVAGDLKTMQEEMRKLVLQ---- 66
            :|||.::..:  ||                      :.|:.||...|     |::...:||
Human   134 HGPPTENTGEPISS----------------------EHLHRAVSVND-----EDLLVRILQGGRV 171

  Fly    67 -VDQPVKGGLNLLMLACREGHYKIVEWLLERAGANVNRQ----LDSLMPLMMACNTTHKDPCLAE 126
             ||.|.|.|...||:|.::|:.::|:.|:.. |.:||.:    .||   ||:||...|.|
Human   172 KVDVPNKFGFTALMVAAQKGYTRLVKILVSN-GTDVNLKNGSGKDS---LMLACYAGHLD----- 227

  Fly   127 RIVGLLLRHGAVINVSEKYGMTPFMFACQNGFAGVVRLLIKD-ASFDAVD-NQGCTAIFH--AIE 187
             :|..|.||||.....:..|.|...:|...|...|:..:||| ...|.|| ..|.|.:..  |:.
Human   228 -VVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVS 291

  Fly   188 KNHVEVVKLLVEAGANATIANNKGYTPTQVAECHGYYDLLEILPRPASTYLVPTHFLGYNTLRDH 252
            .|. .|..||::||||..:.:..|.||..||..:.:.:|:::|....:...|...| |...|  .
Human   292 GNQ-RVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEF-GKGVL--E 352

  Fly   253 IPRIFLKSDCPEYFQE 268
            :.|:|.:.......:|
Human   353 MARVFDRQSVVSLLEE 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gasz	NP_610362.1	Ank_2	44..141	CDD:289560	35/105 (33%)
		ANK repeat	73..106	CDD:293786	10/36 (28%)
		ANK	74..198	CDD:238125	41/131 (31%)
		ANK repeat	110..143	CDD:293786	12/32 (38%)
		Ank_2	111..208	CDD:289560	34/100 (34%)
		ANK repeat	145..175	CDD:293786	9/30 (30%)
		ANK repeat	177..208	CDD:293786	11/32 (34%)
		SAM	273..324	CDD:197735
		SAM_superfamily	273..321	CDD:188886
		PHA03233	<289..>366	CDD:223016
FANK1	XP_011538650.1	FN3	19..103	CDD:214495
		Ank_2	150..243	CDD:315466	35/107 (33%)
		ANK repeat	150..177	CDD:293786	9/31 (29%)
		ANK repeat	179..210	CDD:293786	10/31 (32%)
		ANK	207..334	CDD:238125	43/136 (32%)
		ANK repeat	212..243	CDD:293786	14/39 (36%)
		ANK repeat	245..311	CDD:293786	22/66 (33%)
		ANK	308..>366	CDD:238125	13/60 (22%)
		ANK repeat	313..344	CDD:293786	8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910