DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gasz and ANKRD50

DIOPT Version :9

Sequence 1:	NP_610362.1	Gene:	Gasz / 35795	FlyBaseID:	FBgn0033273	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	NP_065070.1	Gene:	ANKRD50 / 57182	HGNCID:	29223	Length:	1429	Species:	Homo sapiens

Alignment Length:	435	Identity:	97/435 - (22%)
Similarity:	167/435 - (38%)	Gaps:	124/435 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LMLACREGHYKIVEWLLERAGANVNR-QLDSLMPLMMACNTTHKDPCLAERIVGLLLRHGAVINV 141
            |.:...:||..:|..|::| ||.|:. ..|.:.||::|....|.|      :|.|||..||.::.
Human   719 LCVPASKGHASVVSLLIDR-GAEVDHCDKDGMTPLLVAAYEGHVD------VVDLLLEGGADVDH 776

  Fly   142 SEKYGMTPFMFACQNGFAGVVR-LLIKDASFDAVDNQGCTAIFHAIEKNHVEVVKLLVEAGANAT 205
            ::..|.||.:.|...|.|.||. ||...|:.|::|::|.|.:..|..:.:||||:.|::.|.:..
Human   777 TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841

  Fly   206 IANNKGYTPTQVA--ECH-------------------------------GYYDLLEILPRPASTY 237
            ..::.|:||..:|  |.|                               |:||.::||....|.
Human   842 HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSN- 905

  Fly   238 LVPTHFLGYNTLR--------------------------DHIPRIFL-----KSDCPEYFQELNG 271
            :....:.|.|.||                          |..|.:::     :....|||.|...
Human   906 IDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGA 970

  Fly   272 ILE--------AINIGNMVQYFAIARISL---ADFLVMDEQSLREIGIEYPIFR-HKILTGILDF 324
            .:|        |:::.....:..:.::.:   ||....|.:  :...::...:: |..:..:|..
Human   971 NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNE--KRSALQSAAWQGHVKVVQLLIE 1033

  Fly   325 H---LHHWSNSSIARVKKDEMNNFYEILLITASHLQHLVIIQASLRFILKNQEHNKMGQPSEMQV 386
            |   :.|..|....             .|..|:...|:.::|..|.........::.|: :.|:|
Human  1034 HGAVVDHTCNQGAT-------------ALCIAAQEGHIDVVQVLLEHGADPNHADQFGR-TAMRV 1084

  Fly   387 AAMKSNLQGYRDVLNQITKTV-KY----LGSFSPS------QNPL 420
            ||...:        :||.|.: ||    |...|||      |.||
Human  1085 AAKNGH--------SQIIKLLEKYGASSLNGCSPSPVHTMEQKPL 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gasz	NP_610362.1	Ank_2	44..141	CDD:289560	21/63 (33%)
		ANK repeat	73..106	CDD:293786	9/28 (32%)
		ANK	74..198	CDD:238125	41/121 (34%)
		ANK repeat	110..143	CDD:293786	11/32 (34%)
		Ank_2	111..208	CDD:289560	32/97 (33%)
		ANK repeat	145..175	CDD:293786	12/30 (40%)
		ANK repeat	177..208	CDD:293786	9/30 (30%)
		SAM	273..324	CDD:197735	7/62 (11%)
		SAM_superfamily	273..321	CDD:188886	6/59 (10%)
		PHA03233	<289..>366	CDD:223016	12/83 (14%)
ANKRD50	NP_065070.1	AAA_16	22..195	CDD:289934
		Cas9_REC	<221..>352	CDD:293200
		ANK 1	477..509
		ANK	<495..598	CDD:238125
		ANK 2	511..540
		Ank_5	531..585	CDD:290568
		ANK repeat	544..575	CDD:293786
		ANK 3	544..573
		ANK	573..697	CDD:238125
		ANK repeat	577..608	CDD:293786
		ANK 4	577..606
		Ank_2	582..674	CDD:289560
		ANK repeat	610..641	CDD:293786
		ANK 5	610..639
		ANK repeat	643..674	CDD:293786
		ANK 6	643..672
		Ank_2	648..745	CDD:289560	9/26 (35%)
		ANK repeat	676..707	CDD:293786
		ANK 7	676..705
		ANK repeat	709..745	CDD:293786	9/26 (35%)
		ANK 8	709..743		9/24 (38%)
		ANK	742..867	CDD:238125	40/130 (31%)
		ANK repeat	747..778	CDD:293786	12/36 (33%)
		ANK 9	747..776		12/34 (35%)
		Ank_2	752..844	CDD:289560	32/97 (33%)
		ANK repeat	780..811	CDD:293786	12/30 (40%)
		ANK 10	780..809		11/28 (39%)
		ANK	808..932	CDD:238125	27/124 (22%)
		ANK repeat	813..844	CDD:293786	9/30 (30%)
		ANK 11	813..842		9/28 (32%)
		ANK 12	846..875		6/28 (21%)
		ANK repeat	847..877	CDD:293786	6/29 (21%)
		Ank_2	851..943	CDD:289560	13/92 (14%)
		ANK repeat	879..910	CDD:293786	6/31 (19%)
		ANK 13	879..908		6/29 (21%)
		ANK repeat	912..943	CDD:293786	4/30 (13%)
		ANK 14	912..941		4/28 (14%)
		ANK repeat	945..976	CDD:293786	7/30 (23%)
		ANK 15	945..974		6/28 (21%)
		Ank_4	946..999	CDD:290365	7/52 (13%)
		ANK	974..1097	CDD:238125	22/146 (15%)
		ANK repeat	978..1009	CDD:293786	3/30 (10%)
		ANK 16	978..1007		3/28 (11%)
		Ank_2	983..1075	CDD:289560	13/106 (12%)
		ANK repeat	1011..1042	CDD:293786	4/32 (13%)
		ANK 17	1011..1040		3/30 (10%)
		ANK repeat	1044..1075	CDD:293786	5/43 (12%)
		ANK 18	1044..1073		5/41 (12%)
		Ank_2	1049..>1110	CDD:289560	16/69 (23%)
		ANK 19	1077..1107		11/38 (29%)
		ANK repeat	1077..1102	CDD:293786	10/33 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1108..1200		6/14 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1217..1296
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910