DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gasz and nfkb2

DIOPT Version :9

Sequence 1:	NP_610362.1	Gene:	Gasz / 35795	FlyBaseID:	FBgn0033273	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	NP_001005032.1	Gene:	nfkb2 / 448550	XenbaseID:	XB-GENE-970084	Length:	946	Species:	Xenopus tropicalis

Alignment Length:	188	Identity:	43/188 - (22%)
Similarity:	80/188 - (42%)	Gaps:	22/188 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LYDAVVAGDLKTMQEEMRKLVLQVDQPVKGGLNLLMLACREGHYKIVEWLLERAGANVNRQLDSL 108
            |.|..:..|.:.:....|.|:...|:   .|...|.||...|...::|.|::...:..|:|:.::
Frog   478 LLDYAITADPRMLLAVQRHLIATQDE---NGDTPLHLAVIHGQPSVIEQLVQVIISIPNQQILNM 539

  Fly   109 ------MPLMMACNTTHKDPCLAERIVGLLLRHGAVINVSEKYGMTPFMFACQNGFAGVVRLLIK 167
                  .||.:...|....      :|..||:.||...:.::||.:....|.|.....::.:|:|
Frog   540 SNHLQQTPLHLGVITKQYS------VVAFLLKAGADPTILDRYGNSVLHLAVQAEDDKMLSVLLK 598

  Fly   168 DAS------FDAVDNQGCTAIFHAIEKNHVEVVKLLVEAGANATIANNK-GYTPTQVA 218
            ..|      .:..|..|...:..:::..:.:.::|||:||||......| |.:|..:|
Frog   599 YPSVGQKDLLNMPDYHGLCPVHWSVKMKNEKCLELLVKAGANVNSPERKSGKSPLHIA 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gasz	NP_610362.1	Ank_2	44..141	CDD:289560	23/102 (23%)
		ANK repeat	73..106	CDD:293786	9/32 (28%)
		ANK	74..198	CDD:238125	27/135 (20%)
		ANK repeat	110..143	CDD:293786	8/32 (25%)
		Ank_2	111..208	CDD:289560	23/102 (23%)
		ANK repeat	145..175	CDD:293786	7/35 (20%)
		ANK repeat	177..208	CDD:293786	8/30 (27%)
		SAM	273..324	CDD:197735
		SAM_superfamily	273..321	CDD:188886
		PHA03233	<289..>366	CDD:223016
nfkb2	NP_001005032.1	RHD-n_NFkB2	44..227	CDD:143650
		RHD_dimer	235..334	CDD:292797
		Ank_4	476..525	CDD:290365	12/49 (24%)
		ANK	501..635	CDD:238125	28/142 (20%)
		ANK repeat	504..541	CDD:293786	9/36 (25%)
		ANK repeat	543..574	CDD:293786	8/36 (22%)
		Ank_2	548..642	CDD:289560	23/99 (23%)
		ANK	572..703	CDD:238125	20/85 (24%)
		ANK repeat	614..645	CDD:293786	8/30 (27%)
		Ank_2	620..713	CDD:289560	11/37 (30%)
		ANK repeat	648..680	CDD:293786	3/9 (33%)
		ANK repeat	682..707	CDD:293786
		Death_NFkB2_p100	828..903	CDD:176776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000