DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gasz and trpn1

DIOPT Version :9

Sequence 1:	NP_610362.1	Gene:	Gasz / 35795	FlyBaseID:	FBgn0033273	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	NP_899192.1	Gene:	trpn1 / 368273	ZFINID:	ZDB-GENE-030728-7	Length:	1614	Species:	Danio rerio

Alignment Length:	421	Identity:	93/421 - (22%)
Similarity:	159/421 - (37%)	Gaps:	138/421 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EQKLYDAVVAGDLKTMQEEMR-----KLVLQVDQPVKGGLNLLMLACREGHYKIVEWLLERAGAN 100
            |..|:.:...|:...:||.:|     ::...:::..|.|.:.|:||..:||.::|:.||:.
Zfish   541 ETPLHYSARVGNTAVLQEMLRNVPTNQIQTAINKHSKNGWSPLLLAADQGHTEVVKILLQN---- 601

  Fly   101 VNRQLD-----SLMPLMMACNTTHKDPCLAERIVGLLLRHGAVINVSEKYGMTPFMFACQNGFAG 160
             |.::|     ....:.:|....|:|      ||.:||...|.:|...|.|:||...:.|||.|.
Zfish   602 -NARVDVFDEEGKAAIHLAAQRGHQD------IVDVLLSQKAFVNAKTKQGLTPLHLSAQNGSAR 659

  Fly   161 VVRLLIKD--ASFDAV---------------------------------DNQGCTAIFHAIEKNH 190
            :||||:::  ||.||:                                 |::|.|.:..|.|.:|
Zfish   660 LVRLLVENHQASVDALSLRKQTPLHLAAMSGQLDVCSSLLNLRADITATDSRGQTPLHLAAESDH 724

  Fly   191 VEVVKLLVEAGAN-ATIANNKGYTPTQVAECHGYYDLLEILPRPASTYLVPTHFLGYNTLRDHIP 254
            .|||||.:..... :|:||..|.|.|.:|...|...::.        .|:..:..|..||.....
Zfish   725 SEVVKLFLRLRPELSTLANEDGSTCTHIAAAKGSVSVIR--------ELLMFNQGGVGTLNHKAH 781

  Fly   255 RIFLKSDCPEYFQELNGILEAINIGNMVQYFAIARISLADFLVMDEQSLREIGIEYPIFRHKILT 319
            .:     ||.:.....|..|.:.:                        |.|.|
Zfish   782 GL-----CPLHLAAAGGHAEVVKV------------------------LLEAG------------ 805

  Fly   320 GILDFHLHHWSNSSIARVKKDEMNNFYEILLITASHL--QH-----LVIIQASLRFILKNQEHNK 377
                           |.|.:::...      :||.||  :|     |.:::.|:.  ||.|. :|
Zfish   806 ---------------ASVTEEDAEG------MTAVHLAAKHGHTHILEVLRGSVP--LKIQS-SK 846

  Fly   378 MGQPSEMQVAAMKSNLQGYRDVLNQITKTVK 408
            .|. :.:.|||....:...|::|.::..|::
Zfish   847 TGF-TALHVAASFGQMNFVREILTKVPATIR 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gasz	NP_610362.1	Ank_2	44..141	CDD:289560	25/106 (24%)
		ANK repeat	73..106	CDD:293786	10/32 (31%)
		ANK	74..198	CDD:238125	47/163 (29%)
		ANK repeat	110..143	CDD:293786	9/32 (28%)
		Ank_2	111..208	CDD:289560	37/132 (28%)
		ANK repeat	145..175	CDD:293786	15/64 (23%)
		ANK repeat	177..208	CDD:293786	11/31 (35%)
		SAM	273..324	CDD:197735	4/50 (8%)
		SAM_superfamily	273..321	CDD:188886	4/47 (9%)
		PHA03233	<289..>366	CDD:223016	11/83 (13%)
trpn1	NP_899192.1	ANK repeat	47..78	CDD:293786
		Ank_4	48..101	CDD:290365
		ANK	77..239	CDD:238125
		ANK repeat	80..111	CDD:293786
		ANK repeat	113..148	CDD:293786
		ANK repeat	150..184	CDD:293786
		Ank_2	155..250	CDD:289560
		ANK	182..300	CDD:238125
		ANK repeat	186..217	CDD:293786
		ANK repeat	219..250	CDD:293786
		ANK	247..373	CDD:238125
		Ank_4	254..300	CDD:290365
		ANK repeat	286..317	CDD:293786
		Ank_2	291..382	CDD:289560
		ANK repeat	319..350	CDD:293786
		ANK	347..474	CDD:238125
		ANK repeat	352..382	CDD:293786
		Ank_4	389..441	CDD:290365
		ANK repeat	420..450	CDD:293786
		Ank_2	425..535	CDD:289560
		ANK repeat	496..536	CDD:293786
		ANK	539..665	CDD:238125	38/134 (28%)
		ANK repeat	540..576	CDD:293786	6/34 (18%)
		Ank_2	544..641	CDD:289560	26/107 (24%)
		ANK repeat	578..609	CDD:293786	11/35 (31%)
		ANK	606..732	CDD:238125	37/131 (28%)
		ANK repeat	611..642	CDD:293786	9/36 (25%)
		Ank_2	616..709	CDD:289560	25/98 (26%)
		ANK repeat	644..674	CDD:293786	13/29 (45%)
		ANK repeat	678..709	CDD:293786	0/30 (0%)
		Ank_2	683..812	CDD:289560	32/192 (17%)
		ANK repeat	745..812	CDD:293786	18/130 (14%)
		ANK repeat	749..780	CDD:293786	7/38 (18%)
		ANK	781..918	CDD:238125	27/162 (17%)
		Ank_4	815..865	CDD:290365	15/59 (25%)
		ANK repeat	847..895	CDD:293786	7/31 (23%)
		ANK	896..1053	CDD:238125
		ANK repeat	897..964	CDD:293786
		Ank_2	902..997	CDD:289560
		ANK repeat	966..997	CDD:293786
		Ank_2	971..1058	CDD:289560
		ANK repeat	999..1030	CDD:293786
		Ion_trans	<1342..1480	CDD:278921
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000