DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gasz and trp-4

DIOPT Version :9

Sequence 1:	NP_610362.1	Gene:	Gasz / 35795	FlyBaseID:	FBgn0033273	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	NP_493429.2	Gene:	trp-4 / 190574	WormBaseID:	WBGene00006616	Length:	1924	Species:	Caenorhabditis elegans

Alignment Length:	595	Identity:	124/595 - (20%)
Similarity:	197/595 - (33%)	Gaps:	214/595 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LVLQ----VDQPVKGGLNLLMLACREGHYKIVEWLLERAGANVNR-QLDSLMPLMMACNTTHKDP 122
            |:||    |:...|.|...|.||.:.||.|:|..|::..||.:.. .||:...|..|.    |..
Worm   938 LLLQHKAFVNSKSKTGEAPLHLAAQHGHVKVVNVLVQDHGAALEAITLDNQTALHFAA----KFG 998

  Fly   123 CLAERIVGLLLRHGAVINVSEKYGMTPFMFACQNGFAGVVRLLIK-----DASFDAVDNQG---- 178
            .||  :...||..||..|..:..|.||...|.:|.|..||:|.:|     .:...|:|:.|
Worm   999 QLA--VSQTLLALGANPNARDDKGQTPLHLAAENDFPDVVKLFLKMRNNNRSVLTAIDHNGFTCA 1061

  Fly   179 --------------------------------CTAIFHAIEKNHVEVVKLLVEAGANATIANNKG 211
                                            .|.:..|....|..:||:|:|.||||...|:.|
Worm  1062 HIAAMKGSLAVVRELMMIDKPMVIQAKTKTLEATTLHMAAAGGHANIVKILLENGANAEDENSHG 1126

  Fly   212 YTPTQVAECHGYYDLLE----ILPRPAS--TYLVPTHFLGY-------NTLRDHIPRIFLKSDCP 263
            .|...:...:|:..:||    ||.:..|  |.|...|...:       |.:..|: :..::|:.|
Worm  1127 MTALHLGAKNGFISILEAFDKILWKRCSRKTGLNALHIAAFYGNSDFVNEMLKHV-QATVRSEPP 1190

  Fly   264 EYFQELNGILEA------INIGNMVQYFAIARISLADFLVMDEQS--LREIGIEYPIFR-HKILT 319
            .|...:|.....      :::.....:.::.|:.|...:.:|..|  :..|.:.....: |..:.
Worm  1191 IYNHHVNKEFSTEYGFTPLHLAAQSGHDSLVRMLLNQGVQVDATSTTMNVIPLHLAAQQGHIAVV 1255

  Fly   320 GIL------DFHLHHWSNSSIARVKKDEMNNFYEI--LLIT------------------ASHLQH 358
            |:|      ..|...|...:...:.  ..|..||:  |||.                  |:...|
Worm  1256 GMLLSRSTQQQHAKDWRGRTPLHLA--AQNGHYEMVSLLIAQGSNINVMDQNGWTGLHFATRAGH 1318

  Fly   359 LVIIQ-----------------------------ASLRFILKNQEHNK----------------- 377
            |.:::                             ..|||:|| |:|:.
Worm  1319 LSVVKLFIDSSADPLAETKEGKVPLCFAAAHNHIECLRFLLK-QKHDTHQLMEDRKFIFDLMVCG 1382

  Fly   378 ------------MGQPSEMQVAAMKSNLQGYR-----------DVLN----QITKTVKYLGSFSP 415
                        :..|:.::.|...|.|  ||           |:||    .....|:.||..:.
Worm  1383 KTNDNEPLQEFILQSPAPIETAVKLSAL--YRDMSEKEKERAKDLLNVAVFSENMAVELLGITAT 1445

  Fly   416 SQN-------------PLFIDFNEILAERKRKKVRSYF---KYTT--------------IILGIS 450
            ..|             ||.    ::|.|.::|:|.||.   :|.|              :...:.
Worm  1446 EYNAALLLKAKDNRGRPLL----DVLIENEQKEVVSYASVQRYLTEVWTARVDWSFGKFVAFSLF 1506

  Fly   451 VFICLKCKWF 460
            |.||... ||
Worm  1507 VLICPPA-WF 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gasz	NP_610362.1	Ank_2	44..141	CDD:289560	27/82 (33%)
		ANK repeat	73..106	CDD:293786	11/33 (33%)
		ANK	74..198	CDD:238125	41/165 (25%)
		ANK repeat	110..143	CDD:293786	10/32 (31%)
		Ank_2	111..208	CDD:289560	34/137 (25%)
		ANK repeat	145..175	CDD:293786	11/34 (32%)
		ANK repeat	177..208	CDD:293786	12/66 (18%)
		SAM	273..324	CDD:197735	8/65 (12%)
		SAM_superfamily	273..321	CDD:188886	6/56 (11%)
		PHA03233	<289..>366	CDD:223016	19/134 (14%)
trp-4	NP_493429.2	ANK repeat	804..842	CDD:293786
		ANK repeat	849..884	CDD:293786
		ANK repeat	886..917	CDD:293786
		ANK repeat	919..950	CDD:293786	4/11 (36%)
		ANK repeat	952..982	CDD:293786	11/29 (38%)
		ANK repeat	986..1017	CDD:293786	11/36 (31%)
		PHA03095	1006..>1336	CDD:222980	66/332 (20%)
		ANK repeat	1092..1123	CDD:293786	11/30 (37%)
		ANK repeat	1204..1236	CDD:293786	3/31 (10%)
		trp	1209..1879	CDD:273311	54/317 (17%)
		ANK repeat	1238..1270	CDD:293786	5/31 (16%)
		ANK repeat	1272..1303	CDD:293786	6/32 (19%)
		ANK repeat	1305..1336	CDD:293786	3/30 (10%)
		ANK repeat	1338..1366	CDD:293786	7/28 (25%)
		ANKYR	280..515	CDD:223738
		ANK repeat	352..383	CDD:293786
		ANK repeat	385..418	CDD:293786
		ANK repeat	424..454	CDD:293786
		PHA03095	430..>756	CDD:222980
		ANK repeat	456..489	CDD:293786
		ANK repeat	491..523	CDD:293786
		ANK repeat	526..556	CDD:293786
		ANK repeat	558..590	CDD:293786
		ANK repeat	592..623	CDD:293786
		ANK repeat	625..656	CDD:293786
		ANK repeat	658..688	CDD:293786
		ANK repeat	692..726	CDD:293786
		PHA02876	<712..>1040	CDD:165207	37/107 (35%)
		ANK repeat	728..753	CDD:293786
		ANK repeat	761..802	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000