DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gasz and Asz1

DIOPT Version :9

Sequence 1:	NP_610362.1	Gene:	Gasz / 35795	FlyBaseID:	FBgn0033273	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	NP_570106.1	Gene:	Asz1 / 170578	RGDID:	621579	Length:	475	Species:	Rattus norvegicus

Alignment Length:	486	Identity:	116/486 - (23%)
Similarity:	201/486 - (41%)	Gaps:	56/486 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MSNLCKYGPPPDSDS-DSSYDGFYF---SDKVKRSKPAPYVDPEQKLYDAVVAGDLKTMQEEMRK 62
            :..|...|....||| |..:|..|.   |.|:|||.|..  :..:....|:..||: ::.:|:..
  Rat     6 LRGLAVAGGGESSDSEDDGWDIGYLDRSSQKLKRSLPVE--EKNETFKKALTTGDI-SLVKELLD 67

  Fly    63 LVLQVDQPVKGGLNLLMLACREGHYKIVEWLLERAGANVNRQLDSLMPLMMACNTTHKDPCLAER 127
            ..:.||...:.|...||.|....:.::|.:||:| |||.:...|.|..|:.||:....:..:. :
  Rat    68 SGINVDSSFRYGWTPLMYAASVANVELVRFLLDR-GANASFDKDKLTVLITACSARGSEEQVL-K 130

  Fly   128 IVGLLLRHGAVINVSEKYGMTPFMFACQNGFAGVVRLLI-KDASFDAVDNQGCTAIFHAIEKNHV 191
            .|.|||...|..||:.:..|||.|:|.::|...||.||: ..|..:|.|..|.||:..|..:.|.
  Rat   131 CVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNAQDENGYTALTWAARQGHK 195

  Fly   192 EVVKLLVEAGANATIANNKGYTPTQVAECHGYYDLLEILPRPASTYLVPTHFLGYNTLRDHIPRI 256
            .|:..|:|.|||..:....|.||:::|:.:.:.::...|.            |..|.|...:.::
  Rat   196 NVILKLLELGANKMLQTKDGRTPSEIAKRNKHLEIFNFLS------------LTLNPLEGKLQQL 248

  Fly   257 --------FLKSDCPE----------YFQELNGILEAINIGNMVQYFAIARISLADFLVMDEQSL 303
                    .|.:|..:          .|.:|...|..:.:.:|........|:|...|.|.:..|
  Rat   249 TKEETICKLLATDSDKEKDHIFSPYTAFGDLEIFLHGLGLEHMTDLLKERDITLRHLLTMKKDEL 313

  Fly   304 REIGIEYPIFRHKILTGILDFHLHHWSNSSIARVKKDEM--NNFYEILLITASHLQHLVIIQASL 366
            .:.||... .:.|||..:.:..:...:...:..|.|.|:  :.|...||.......||:....::
  Rat   314 TKNGITSK-DQQKILAALKELEVEEINFGKLPEVAKLEISGDEFLNFLLKLNKQCGHLITAVQNI 377

  Fly   367 RFILKNQEHN---KMGQPSEMQVAA--MKSNLQGYRDVLNQITKTVKYLGS---FSPSQNPLFID 423
            ...|....|.   :...|.......  :.||::...:.:.::.:.::.:.:   ..|:..||
  Rat   378 ITELPVNSHKIVLEWASPRNFTSVCEELVSNVEDLNEEVCRLKELIQKMQNERENDPTHIPL--- 439

  Fly   424 FNEILAERKRKKVRSYFKYTTIILGISVFIC 454
            ..|:...:.|...||  ..|....|:.:|||
  Rat   440 VEEVSPWKTRILKRS--AVTVCGFGLLLFIC 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gasz	NP_610362.1	Ank_2	44..141	CDD:289560	27/96 (28%)
		ANK repeat	73..106	CDD:293786	11/32 (34%)
		ANK	74..198	CDD:238125	42/124 (34%)
		ANK repeat	110..143	CDD:293786	10/32 (31%)
		Ank_2	111..208	CDD:289560	34/97 (35%)
		ANK repeat	145..175	CDD:293786	12/30 (40%)
		ANK repeat	177..208	CDD:293786	11/30 (37%)
		SAM	273..324	CDD:197735	12/50 (24%)
		SAM_superfamily	273..321	CDD:188886	12/47 (26%)
		PHA03233	<289..>366	CDD:223016	18/78 (23%)
Asz1	NP_570106.1	Ank_4	47..99	CDD:372654	11/52 (21%)
		ANKYR	<78..214	CDD:223738	47/137 (34%)
		ANK repeat	78..146	CDD:293786	23/69 (33%)
		ANK repeat	151..179	CDD:293786	11/27 (41%)
		ANK repeat	181..212	CDD:293786	11/30 (37%)
		SAM_ASZ1	273..333	CDD:188920	14/60 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47586
OrthoDB	1	1.010	-	-		D1428188at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108694
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830