DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gasz and MIB2

DIOPT Version :9

Sequence 1:	NP_610362.1	Gene:	Gasz / 35795	FlyBaseID:	FBgn0033273	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	XP_016855838.1	Gene:	MIB2 / 142678	HGNCID:	30577	Length:	1297	Species:	Homo sapiens

Alignment Length:	274	Identity:	65/274 - (23%)
Similarity:	111/274 - (40%)	Gaps:	52/274 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SNLCKYGPPPDSDSDSSYDGFYFSDKVKRSKPAPYV----------DPEQ--KLYDAVVAGDLKT 55
            |.|..|.|..|::.|       .:::.:.:|.:..|          |||.  :|...|..|:...
Human   675 SCLVAYRPEEDANLD-------VAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAAR 732

  Fly    56 MQEEMRKLVLQVDQPVKGGLNLLMLACREGHYKIVEWLLE-RAG--------------ANVNRQL 105
            ..:.:|:...|||.. ..|...|.:|...|..:::..||: |||              |.:..|.
Human   733 ALDLLRRRPEQVDTK-NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQP 796

  Fly   106 DSLMPLMMA-C-----NTTHKDP--CLAER----IVGLLLRHGAVINVSEKYGMTPFMFACQ--N 156
            ::...|:.| |     |:|....  ...:|    :|..|...|..:|:.:.:..||...|..  .
Human   797 EATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGT 861

  Fly   157 GFAGVVRLLIKDASFD--AVDNQGCTAIFHAIEKNH-VEVVKLLVEAGANATIANNKGYTPTQVA 218
            |.:|:|.:|.:..:.|  |.::||.|.:.||..|.| :.|.|:|..|..........|:|...:|
Human   862 GASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLA 926

  Fly   219 ECHGYYDLLEILPR 232
            ..:.:.::.:||.|
Human   927 ALNNHREVAQILIR 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gasz	NP_610362.1	Ank_2	44..141	CDD:289560	27/123 (22%)
		ANK repeat	73..106	CDD:293786	11/47 (23%)
		ANK	74..198	CDD:238125	39/155 (25%)
		ANK repeat	110..143	CDD:293786	10/44 (23%)
		Ank_2	111..208	CDD:289560	30/113 (27%)
		ANK repeat	145..175	CDD:293786	9/33 (27%)
		ANK repeat	177..208	CDD:293786	11/31 (35%)
		SAM	273..324	CDD:197735
		SAM_superfamily	273..321	CDD:188886
		PHA03233	<289..>366	CDD:223016
MIB2	XP_016855838.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000