DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gasz and AgaP_AGAP004499

DIOPT Version :9

Sequence 1:	NP_610362.1	Gene:	Gasz / 35795	FlyBaseID:	FBgn0033273	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	XP_003436828.1	Gene:	AgaP_AGAP004499 / 1274645	VectorBaseID:	AGAP004499	Length:	669	Species:	Anopheles gambiae

Alignment Length:	424	Identity:	102/424 - (24%)
Similarity:	160/424 - (37%)	Gaps:	108/424 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LKTMQEEMRKLVLQVDQPVKGGLNLLMLACREGHYKIVEWL------------------------ 93
            |:.:..:|||   :|.:....|.:.|.:|||.|:..|.|:|
Mosquito    58 LERLPRKMRK---EVVKRTSDGCSPLFIACRRGNVYITEYLITVCEADSEQKGLYEVPEDRSVHC 119

  Fly    94 ------------------LERAGANVNRQLDS-LMPLMMACNTTHKDPCLAERIVGLLLRHGAVI 139
                              |.|.|:|:|...|: ..||..||..||.|      ||..|:.|||.|
Mosquito   120 VTPLWCACVSGKLPVVKCLVRLGSNINALSDTGSTPLRSACFMTHID------IVQFLVEHGADI 178

  Fly   140 NVSEKYGMTPFMFACQNGFAGVVRLLIKDASFDAVDNQGCTAIFHAIEKNHVEVVKLLVEAGANA 204
            ......|.|..:.:.|: ......|:.|.|..:|.|.|..||:.:||:::.:|..:||:|.||:.
Mosquito   179 RKPNYNGGTCLINSVQS-VTLCTYLISKGADVNARDIQNKTALHYAIQEHRLETAQLLLEHGADP 242

  Fly   205 TIANNKGYTPTQVAECHGYYDLLEILPRP---ASTYLVPTHFLGYNTLRDHI------------- 253
            ...::.|....|.|...|.|.:.:.|.:.   ::..|...|.|..:||.|.:
Mosquito   243 FAKSHYGDDALQTACLKGAYHIFDYLKKRINYSAERLADAHELFGSTLIDDLNVTRGAVLHWRMA 307

  Fly   254 PRIFLKSDCPEYFQELNGILEAINIGNMVQYFAIARIS--LADFLVMDEQSL----REIGIEY-- 310
            .:|.|:.  .||..:...:......|...::..|..:.  .||...|..|||    |.:||::
Mosquito   308 HQIRLRE--AEYITKKPPVEPRAAYGFASEFTTIPELDNIAADMDAMRVQSLLIYERILGIDHRD 370

  Fly   311 PIFRHKIL-TGILDFH-----LHHWSNSSIARVKKDEMNNFYEIL----LITASHLQHLVIIQAS 365
            .:||.... ....|.|     :..|..:...||:|      |.||    .:||         ||.
Mosquito   371 TLFRLMFRGASYADAHRFQRCIDLWLLALQVRVQK------YSILYSDTCLTA---------QAL 420

  Fly   366 LRFILKNQEHNKMGQPSEMQVAAMKSNLQGYRDV 399
            :|.:|...:    |....|.|...:.::..:.||
Mosquito   421 VRLMLDLID----GYDEMMPVELYEGSVPRFEDV 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gasz	NP_610362.1	Ank_2	44..141	CDD:289560	34/130 (26%)
		ANK repeat	73..106	CDD:293786	14/74 (19%)
		ANK	74..198	CDD:238125	44/166 (27%)
		ANK repeat	110..143	CDD:293786	14/32 (44%)
		Ank_2	111..208	CDD:289560	32/96 (33%)
		ANK repeat	145..175	CDD:293786	7/29 (24%)
		ANK repeat	177..208	CDD:293786	11/30 (37%)
		SAM	273..324	CDD:197735	13/59 (22%)
		SAM_superfamily	273..321	CDD:188886	13/56 (23%)
		PHA03233	<289..>366	CDD:223016	24/94 (26%)
AgaP_AGAP004499	XP_003436828.1	Ank_2	<67..147	CDD:289560	15/82 (18%)
		ANK repeat	75..149	CDD:293786	14/73 (19%)
		ANK	121..236	CDD:238125	35/121 (29%)
		Ank_2	123..245	CDD:289560	39/128 (30%)
		ANK repeat	152..182	CDD:293786	14/35 (40%)
		ANK repeat	184..213	CDD:293786	7/29 (24%)
		ANK repeat	215..245	CDD:293786	11/29 (38%)
		ANK	<558..635	CDD:238125
		ANK repeat	578..611	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
TreeFam	0	0.000	Not matched by this tool.
	1	1.000