DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RagC-D and rragd

DIOPT Version :9

Sequence 1:	NP_610361.1	Gene:	RagC-D / 35793	FlyBaseID:	FBgn0033272	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001092894.2	Gene:	rragd / 570568	ZFINID:	ZDB-GENE-070620-6	Length:	394	Species:	Danio rerio

Alignment Length:	352	Identity:	254/352 - (72%)
Similarity:	295/352 - (83%)	Gaps:	7/352 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDDDDYPADTFPKDFGYRAYNQDGLELEPNATGSSETKPRILLMGMRRSGKSSIQKVVFHKMSPN 67
            ||||| ..|.|....|  ..:.||..|..:...|||.||||||||:|||||||||||||||||||
Zfish    22 YDDDD-DFDAFTDGDG--DCSCDGGVLGFSDPFSSEVKPRILLMGLRRSGKSSIQKVVFHKMSPN 83

  Fly    68 ETLFLESTSKIVKDDINNSSFVQFQIWDFPGQIDFFEPTFDSDMIFGGCGALVFVIDAKDDYNEA 132
            ||||||||:||.::|::|||||.|||||||||||||:||||.:|||.|.|||:||||::|||.||
Zfish    84 ETLFLESTNKICREDVSNSSFVSFQIWDFPGQIDFFDPTFDYEMIFRGTGALIFVIDSQDDYVEA 148

  Fly   133 LTKFKNTVLQAYKVNKRIKFEVFIHKVDGISDDSKMESQRDIHQRSSDDLNEAGLDQIHLSFHLT 197
            |::...||.:|||||..|.||||||||||:|||.|:|.|||||:|::|||.:|||::|||||:||
Zfish   149 LSRLHLTVTRAYKVNPDINFEVFIHKVDGLSDDHKIEKQRDIHKRANDDLADAGLERIHLSFYLT 213

  Fly   198 SIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFIPNSGIEKAFLFDVVSKIYIATDSSPVDMQTYE 262
            |||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||
Zfish   214 SIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQTYE 278

  Fly   263 LCCDMIDVVIDLSSIY--SSEE--TAFDSGSSSLIKLNNNTILYLREVNKFLALVCILREENFNR 323
            |||||||||||:|.||  |.:|  |.:|..|.::|.|||.|::||:||.|||||||.||||:|.:
Zfish   279 LCCDMIDVVIDISCIYGLSGDEGGTPYDKESMAIIHLNNTTVMYLKEVTKFLALVCFLREESFEK 343

  Fly   324 QGVIDYNFICFRDAISEVFELRLKRQK 350
            :|:|||||.||:.||.|||::|||.|:
Zfish   344 KGLIDYNFHCFKKAIEEVFDVRLKVQR 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RagC-D	NP_610361.1	RagC_like	42..216	CDD:206745	134/173 (77%)
rragd	NP_001092894.2	Gem1	58..232	CDD:224025	134/173 (77%)
rragd	NP_001092894.2	RagC_like	58..232	CDD:206745	134/173 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586400
Domainoid	1	1.000	382	1.000	Domainoid score	I790
eggNOG	1	0.900	-	-		E1_KOG3887
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	501	1.000	Inparanoid score	I1330
OMA	1	1.010	-	-		QHG53655
OrthoDB	1	1.010	-	-		D1216811at2759
OrthoFinder	1	1.000	-	-		FOG0002298
OrthoInspector	1	1.000	-	-		otm26371
orthoMCL	1	0.900	-	-		OOG6_102660
Panther	1	1.100	-	-	O	PTHR11259
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R533
SonicParanoid	1	1.000	-	-		X1521
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800