DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RagC-D and Rragc

DIOPT Version :9

Sequence 1:	NP_610361.1	Gene:	RagC-D / 35793	FlyBaseID:	FBgn0033272	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_059503.2	Gene:	Rragc / 54170	MGIID:	1858751	Length:	398	Species:	Mus musculus

Alignment Length:	372	Identity:	257/372 - (69%)
Similarity:	299/372 - (80%)	Gaps:	34/372 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSYDDDDYP-------ADTFPKDFGYRAYNQDGLELEPNAT-----------------GSSETKP 41
            :.|..::.|       ||:|||||||      |:|.|....                 |:..:||
Mouse     3 LQYGAEETPLAGSYGAADSFPKDFGY------GVEEEEEEAAAGGGGGAGAGGGCGPGGADSSKP 61

  Fly    42 RILLMGMRRSGKSSIQKVVFHKMSPNETLFLESTSKIVKDDINNSSFVQFQIWDFPGQIDFFEPT 106
            ||||||:|||||||||||||||||||||||||||:||.||||:|||||.|||||||||:|||:||
Mouse    62 RILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPT 126

  Fly   107 FDSDMIFGGCGALVFVIDAKDDYNEALTKFKNTVLQAYKVNKRIKFEVFIHKVDGISDDSKMESQ 171
            ||.:|||.|.|||::||||:|||.||||:...||.:|||||..:.||||||||||:|||.|:|:|
Mouse   127 FDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQ 191

  Fly   172 RDIHQRSSDDLNEAGLDQIHLSFHLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFIPNSGIE 236
            ||||||::|||.:|||:::||||:|||||||||||||||||||||||||||||||||||.|||||
Mouse   192 RDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIE 256

  Fly   237 KAFLFDVVSKIYIATDSSPVDMQTYELCCDMIDVVIDLSSIYSSEE----TAFDSGSSSLIKLNN 297
            |||||||||||||||||||||||:|||||||||||||:|.||..:|    :|:|..|.::|||||
Mouse   257 KAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNN 321

  Fly   298 NTILYLREVNKFLALVCILREENFNRQGVIDYNFICFRDAISEVFEL 344
            .|:|||:||.||||||||||||:|.|:|:|||||.|||.||.||||:
Mouse   322 TTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEV 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RagC-D	NP_610361.1	RagC_like	42..216	CDD:206745	136/173 (79%)
Rragc	NP_059503.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		14/58 (24%)
Rragc	NP_059503.2	RagC_like	62..236	CDD:206745	136/173 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841963
Domainoid	1	1.000	384	1.000	Domainoid score	I816
eggNOG	1	0.900	-	-		E1_KOG3887
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39141
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1357
Isobase	1	0.950	-	0	Normalized mean entropy	S531
OMA	1	1.010	-	-		QHG53655
OrthoDB	1	1.010	-	-		D1216811at2759
OrthoFinder	1	1.000	-	-		FOG0002298
OrthoInspector	1	1.000	-	-		otm42574
orthoMCL	1	0.900	-	-		OOG6_102660
Panther	1	1.100	-	-	LDO	PTHR11259
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R533
SonicParanoid	1	1.000	-	-		X1521
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750