DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpin and LPIN2

DIOPT Version :9

Sequence 1:	NP_001188884.1	Gene:	Lpin / 35790	FlyBaseID:	FBgn0263593	Length:	1089	Species:	Drosophila melanogaster
Sequence 2:	XP_005258234.1	Gene:	LPIN2 / 9663	HGNCID:	14450	Length:	933	Species:	Homo sapiens

Alignment Length:	1081	Identity:	361/1081 - (33%)
Similarity:	502/1081 - (46%)	Gaps:	319/1081 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPV 70
            :|....::.|..||.|||:|.||||||:|:||.:|||||||||||||||||:|||:||||||..|
Human    47 QVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKLGVLRSKEKVIDIEINGSAV 111

  Fly    71 DIQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDKNASEE 135
            |:.|||||:|||||||| .|:|.|:|||.|||||||.             ||
Human   112 DLHMKLGDNGEAFFVEE-TEEEYEKLPAYLATSPIPT-------------ED------------- 149

  Fly   136 LLLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTTQKIR 200
                         .|.|:.....|..|
Human   150 -------------QFFKDIDTPLVKSG-------------------------------------- 163

  Fly   201 QEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQIKPDVNLTTVTTSE 265
                       |::.|:.|      |..|:..|||                        |:.|..
Human   164 -----------GDETPSQS------SDISHVLETE------------------------TIFTPS 187

  Fly   266 ATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNIDEGDAPISSAT 330
            :.|       ||:|::.:.|::::::..::|:         .:.:|..:|||:.|:..|   .|.
Human   188 SVK-------KKKRRRKKYKQDSKKEEQAASA---------AAEDTCDVGVSSDDDKGA---QAA 233

  Fly   331 NNNNTSSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPRLDLDIHFFSDTEITTPVGGGGAGSG 395
            ..::.:|..:|:...||: ..:||..|||:...:|               .|.|.|
Human   234 RGSSNASLKEEECKEPLL-FHSGDHYPLSDGDWSP---------------LETTYP--------- 273

  Fly   396 RAAGGRPSTPIQSDSELETTMRDNRHVVTEESTASWKWGELP--------------------TP- 439
                 :.:.| :||||||  ::....::..||...|.||..|                    ||
Human   274 -----QTACP-KSDSELE--VKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPS 330

  Fly   440 ----------------EQAKNEAMS------------AAQVQQSEHQSML--------SNMFSFM 468
                            |..|:.:|.            |...|.|:..|:.        |...|.|
Human   331 ENTHFRVIPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSM 395

  Fly   469 KRANRL---------------------RKEKGVGE------VGDIYLSDLDAGSMDPEMAALYFP 506
            ..|:.|                     .|:|||.:      ..||||.||.  .::||:||||||
Human   396 LDADHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPDDIYLDDLK--GLEPEVAALYFP 458

  Fly   507 SPLSKAASP--PEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNNRYLDFVAMSMCGM 569
            ...|:..|.  ||.|..||:     .||.|:  |..:.||.   |:...|:...|..|.:|:||.
Human   459 KSESEPGSRQWPESDTLSGS-----QSPQSV--GSAAADSG---TECLSDSAMDLPDVTLSLCGG 513

  Fly   570 SEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYTWMAACPIVMTMITFQKPLTHD 634
            ..:....|.|:|..|::.|.:..::|.:..:||||:|:..:||.|..|.|:::::..|||.|...
Human   514 LSENGEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKSLPKA 578

  Fly   635 AIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQDAAPNHLNNTHGMPLGKDEKD 699
            .:|..:...:..|                .|:    ||.||:.:       :.|..:|   :.|:
Human   579 TVESWVKDKMPKK----------------SGR----WWFWRKRE-------SMTKQLP---ESKE 613

  Fly   700 GDQAAVATQTSRPTSPDITDPTLSKSDSLVN-AENTSALVDNLEELTMASNKSDEPKE------- 756
            |...|       |.:.|:  |:.||..:... |||.|:..:..:||..:......|.|
Human   614 GKSEA-------PPASDL--PSSSKEPAGARPAENDSSSDEGSQELEESITVDPIPTEPLSHGST 669

  Fly   757 -RYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVISDIDGTITKS 820
             .|||||||||..|.||.|.:|.|::.||:||.||||.||...::.|..|||::|||||||||||
Human   670 TSYKKSLRLSSDQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDKIIISDIDGTITKS 734

  Fly   821 DVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYLRSIRQGNVMLPDGP 885
            |.||.|||.:||||...|:|:|:..|.:||||.||.||||||.:.:||.||..:.....:||.||
Human   735 DALGQILPQLGKDWTHQGIAKLYHSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGP 799

  Fly   886 LLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDLF-PDKEPFYAGYGNRINDVWAYRAVGIPIM 949
            |:|:|:||.|||||||||||||:|||.||:||::|| |.|:||||.:|||.|||:||..||:|..
Human   800 LMLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQVGVPDC 864

  Fly   950 RIFTINTKGELKHELTQTFQSSGYINQSLEVDEYFPLLTNQ 990
            ||||:|.||||..|.|:..:|| |...|..|:..||||:.:
Human   865 RIFTVNPKGELIQERTKGNKSS-YHRLSELVEHVFPLLSKE 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436	66/96 (69%)
		Lipin_mid	562..671	CDD:293481	27/108 (25%)
		LNS2	760..985	CDD:285447	132/225 (59%)
LPIN2	XP_005258234.1	Lipin_N	38..143	CDD:282436	66/96 (69%)
		Lipin_mid	506..596	CDD:293481	27/109 (25%)
		LNS2	674..899	CDD:285447	132/225 (59%)
		AF1Q	<913..>932	CDD:259154
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149661
Domainoid	1	1.000	273	1.000	Domainoid score	I1791
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1286
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51957
OrthoDB	1	1.010	-	-		D405645at33208
OrthoFinder	1	1.000	-	-		FOG0001100
OrthoInspector	1	1.000	-	-		otm41350
orthoMCL	1	0.900	-	-		OOG6_100990
Panther	1	1.100	-	-	O	PTHR12181
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R805
SonicParanoid	1	1.000	-	-		X664
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800