DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpin and PITPNM1

DIOPT Version :9

Sequence 1:	NP_001188884.1	Gene:	Lpin / 35790	FlyBaseID:	FBgn0263593	Length:	1089	Species:	Drosophila melanogaster
Sequence 2:	NP_004901.2	Gene:	PITPNM1 / 9600	HGNCID:	9003	Length:	1244	Species:	Homo sapiens

Alignment Length:	1015	Identity:	188/1015 - (18%)
Similarity:	314/1015 - (30%)	Gaps:	341/1015 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 SRDKANDTMEDISGVVTDKNASEELLLPLPLPRRNSIDF--SKEEPKEAVVEGSKFENQVSDYTQ 174
            :||..|.:.|:........:.||| :.|..:.:.||.||  :...|.||  ||
Human   339 ARDSENSSEEEFFDAHEGFSDSEE-VFPKEMTKWNSNDFIDAFASPVEA--EG------------ 388

  Fly   175 RRHTDNTLERRNLSEKLKEFTTQKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAI- 238
                                 |.:...|.|:..|  .|.:.|.||:.||...:...||....|:
Human   389 ---------------------TPEPGAEAAKGIE--DGAQAPRDSEGLDGAGELGAEACAVHALF 430

  Fly   239 -----PAVIEDTEKEKDQIKPDVN--------LTTVTTSEATKEV-------------------- 270
                 ..:::....:.:..:.||.        :|.:...||...|
Human   431 LILHSGNILDSGPGDANSKQADVQTLSSAFEAVTRIHFPEALGHVALRLVPCPPICAAAYALVSN 495

  Fly   271 -----------SKSK------------TKKRRKKSQMKKNAQRKNSSSSSL--GSAGGGDLPSAE 310
                       |:|:            |...|.:..:.....|.|.:.|:.  ...|.|......
Human   496 LSPYSHDGDSLSRSQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYSAFLRSPEGAGFCGQVA 560

  Fly   311 TPSLGVSNIDEGDAPISSA---TNNNNTS---SSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNP 369
            ....||..|...||...||   |.:..:|   |.|:|.||                    |...|
Human   561 LIGDGVGGILGFDALCHSANAGTGSRGSSRRGSMNNELLS--------------------PEFGP 605

  Fly   370 RLDLDIHFFSDTEITTPVGGGGAGSGRAA---GGRPSTPIQSD-SELETTMRDNRHVVTEESTAS 430
                         :..|:..|..|.||.:   ...|...|.|| :..|.....|.......:|:|
Human   606 -------------VRDPLADGVEGLGRGSPEPSALPPQRIPSDMASPEPEGSQNSLQAAPATTSS 657

  Fly   431 WKWGELPT---PEQAKNEA----MSAAQVQQSEHQSMLSNMFSF---MKRANRLRKEKGVGEVGD 485
            |:.....|   |..|.:||    .|.|::     ...:|..|.|   :.....|||
Human   658 WEPRRASTAFCPPAASSEAPDGPSSTARL-----DFKVSGFFLFGSPLGLVLALRK--------- 708

  Fly   486 IYLSDLDAGSMDPEMAALY---------------FPSPLSKAASP---PE-EDGESGNGTSL--- 528
            ..:..|:|..|.|....:|               ..:|..:|.:|   |. :....|:|:||
Human   709 TVMPALEAAQMRPACEQIYNLFHAADPCASRLEPLLAPKFQAIAPLTVPRYQKFPLGDGSSLLLA 773

  Fly   529 ----PHSPSSLEEGQKSIDSDFDETKQQRDNNRYLDFVAMSMCGMSEQGA-----PPSDEEFDRH 584
                .||...|||.:..:.|                 ...|..|...:|:     ||:
Human   774 DTLQTHSSLFLEELEMLVPS-----------------TPTSTSGAFWKGSELATDPPA------- 814

  Fly   585 LVNYPDVCKSPSIFSSPNLVVRLNGKYY-----TWMAACPIVMTMI-TFQKP-LTH-------DA 635
                     .|:..|:.:.||::..:::     .:...||..:|.. |...| |.|       |.
Human   815 ---------QPAAPSTTSEVVKILERWWGTKRIDYSLYCPEALTAFPTVTLPHLFHASYWESADV 870

  Fly   636 IEQLMSQTVDGKCLPGDEKQEAVAQADN----GGQTKRYWWSWRRSQDAAPNHLNNTHGMPLGKD 696
            :..::.|.:       ::::..:|:.:.    .....|..|..:|:|....|..:|...
Human   871 VAFILRQVI-------EKERPQLAECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRA------ 922

  Fly   697 EKDGDQAAVATQTSRPTSPDITDPTLSKSDSLVNAENTSALVDN-----LEELTMASNKSD---- 752
                                        ||::|.......|...     |:.:|:...|.|
Human   923 ----------------------------SDTVVCEGRPQVLSGRFMYGPLDVVTLTGEKVDVYIM 959

  Fly   753 -EP---------KERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDK 807
             :|         .|....|.||:.....:..|..|:..:...|...:   |..:|.|.......:
Human   960 TQPLSGKWIHFGTEVTNSSGRLTFPVPPERALGIGVYPVRMVVRGDH---TYAECCLTVVARGTE 1021

  Fly   808 VVISDIDGTITKSDVLGHILPMVGKD-WAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYL 871
            .|:..|||:.|.|      :.::|.| ..:.|...:....:.:||.::|::.|...|......:|
Human  1022 AVVFSIDGSFTAS------VSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWL 1080

  Fly   872 --RSIRQGNVMLPDGPLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDLFPDKEPFYAGYGNR 934
              .:...|.|...|| |..:|....:.|.:.::::  .:..|.                ||||:.
Human  1081 SQHNFPHGVVSFCDG-LTHDPLRQKAMFLQSLVQE--VELNIV----------------AGYGSP 1126

  Fly   935 INDVWAYRAVGIPIMRIFTINTKGELKHELTQTFQSSGYI 974
             .||..|.|:|:...:.:.:. :...|.:....|.|.||:
Human  1127 -KDVAVYAALGLSPSQTYIVG-RAVRKLQAQCQFLSDGYV 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436
		Lipin_mid	562..671	CDD:293481	20/131 (15%)
		LNS2	760..985	CDD:285447	46/218 (21%)
PITPNM1	NP_004901.2	SRPBCC_PITPNM1-2_like	1..257	CDD:176898
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..331
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..358		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..682		28/133 (21%)
		DDHD	689..879	CDD:280937	43/231 (19%)
		Peptidase_M14NE-CP-C_like	<964..>1028	CDD:304370	11/66 (17%)
		LNS2	1023..1154	CDD:197870	33/157 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1206..1244
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900