Protein Alignment Lpin and PAH1

DIOPT Version :9

• Sequence 1: NP_001188884.1
• Gene: Lpin / 35790
• FlyBaseID: FBgn0263593
• Length: 1089
• Species: Drosophila melanogaster
• Sequence 2: NP_013888.1
• Gene: PAH1 / 855201
• SGDID: S000004775
• Length: 862
• Species: Saccharomyces cerevisiae
• Alignment Length: 1135
• Identity: 287/1135 - (25%)
• Similarity: 420/1135 - (37%)
• Gaps: 484/1135 - (42%)

  Fly     1 MNSLARVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEI 65
            |..:.|...:....::.||.|||:|||||||||..||...||||||||||..:|:..:|.|.:.|
Yeast     1 MQYVGRALGSVSKTWSSINPATLSGAIDVIVVEHPDGRLSCSPFHVRFGKFQILKPSQKKVQVFI 65

  Fly    66 NGVPVDIQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDK 130
            |....::.|||.|||||:||.| :.|:..::|..|..||:
Yeast    66 NEKLSNMPMKLSDSGEAYFVFE-MGDQVTDVPDELLVSPV------------------------- 104

  Fly   131 NASEELLLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFT 195
                          .::.....:.|:.:::||.              |:...|..|.::| ||
Yeast   105 --------------MSATSSPPQSPETSILEGG--------------TEGEGEGENENKK-KE-- 138

  Fly   196 TQKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQIKPDVNLTT 260
             :|:.:|             |...|..|.....|..:||..:    :..||.           :|
Yeast   139 -KKVLEE-------------PDFLDINDTGDSGSKNSETTGS----LSPTES-----------ST 174

  Fly   261 VTTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNIDEGDAP 325
            .|..::.:|        |:...|..||.|:|.:..
Yeast   175 TTPPDSVEE--------RKLVEQRTKNFQQKLNKK------------------------------ 201

  Fly   326 ISSATNNNNTSSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPRLDLDIHFFSDTEITTPVGGG 390
                                            |:|| |.|:   :||.:.....|||
Yeast   202 --------------------------------LTEI-HIPS---KLDNNGDLLLDTE-------- 222

  Fly   391 GAGSGRAAGGRPSTPIQSDSELETTMRDNRHVVTEESTASWKWGELPTPEQAKNEAMSAAQVQQS 455
                    |.:|:..:..|::::.     :.::.:|      :|         |:
Yeast   223 --------GYKPNKNMMHDTDIQL-----KQLLKDE------FG---------ND---------- 249

  Fly   456 EHQSMLSNMFSFMKRANRLRKEKGVGEVGDI-------YLSDLDAGSMDPEMAALYFPSPLSKAA 513
                  |::.||:|      ::|.    |:|       :|:||
Yeast   250 ------SDISSFIK------EDKN----GNIKIVNPYEHLTDL---------------------- 276

  Fly   514 SPPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNNRYLDFVAMSMCGMSEQGAPPSD 578
            |||                                                        |.||
Yeast   277 SPP--------------------------------------------------------GTPP-- 283

  Fly   579 EEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYTWMAACPIVMTMITFQKPLTHDAIEQLMSQT 643
                                                        ||.|....|..||:|
Yeast   284 --------------------------------------------TMATSGSVLGLDAME------ 298

  Fly   644 VDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQDAAPNHLNNTHGMPLGKDEKDGDQAAVATQ 708
                                .|.|                 ||:....|.|.|.:|
Yeast   299 --------------------SGST-----------------LNSLSSSPSGSDTED--------- 317

  Fly   709 TSRPTSPDITDPTLSKSDSLVNAENTSALVDNLEELTMASNKSDEPKERYKKSLRLSSAAIKKLN 773
                      :.:.||..| ..:|.||         ...:..|.|.::||.:::||::..:|.||
Yeast   318 ----------ETSFSKEQS-SKSEKTS---------KKGTAGSGETEKRYIRTIRLTNDQLKCLN 362

  Fly   774 LKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVISDIDGTITKSDVLGHILPMVGKDWAQLG 838
            |..|.|:::|||.   .|.......||.|:.:..:|||||||||||||.|||:|.|:||||..||
Yeast   363 LTYGENDLKFSVD---HGKAIVTSKLFVWRWDVPIVISDIDGTITKSDALGHVLAMIGKDWTHLG 424

  Fly   839 VAQLFSKIEQNGYKLLYLSARAIGQSRVTREYLRSIRQGNVMLPDGPLLLNPTSLISAFHREVIE 903
            ||:|||:|.:|||.:|||:||:.||:..||.|||||.|....||:||::|:|...::|..||||.
Yeast   425 VAKLFSEISRNGYNILYLTARSAGQADSTRSYLRSIEQNGSKLPNGPVILSPDRTMAALRREVIL 489

  Fly   904 KKPEQFKIACLSDIRDLF---PDKE--------PFYAGYGNRINDVWAYRAVGIPIMRIFTINTK 957
            ||||.||||||:|||.|:   .|.|        ||:||:||||.|..:||.||||..|||||||:
Yeast   490 KKPEVFKIACLNDIRSLYFEDSDNEVDTEEKSTPFFAGFGNRITDALSYRTVGIPSSRIFTINTE 554

  Fly   958 GELKHELTQT--FQSSGYINQSLEVDEYFPLLTNQDEFDYRT--------------DIFDDE--- 1003
            ||:..||.:.  ::|| ||:.:..||.:||.: :.|..|.||              |.||.|
Yeast   555 GEVHMELLELAGYRSS-YIHINELVDHFFPPV-SLDSVDLRTNTSMVPGSPPNRTLDNFDSEITS 617

  Fly  1004 ------ESEEELQFSD-----DYDVDVEH----GSSEESSGDEDDDEALYNDDFANDDNGIQ-AV 1052
                  ...:|.:|:|     |..||:::    .:.:..:.|||.|.:..::...|..|.:: |.
Yeast   618 GRKTLFRGNQEEKFTDVNFWRDPLVDIDNLSDISNDDSDNIDEDTDVSQQSNISRNRANSVKTAK 682

  Fly  1053 VASGDERTADVGLIMRVRRVSTKNEVIMAS 1082
            |....:|        .|...:..|||:.||
Yeast   683 VTKAPQR--------NVSGSTNNNEVLAAS 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436	47/101 (47%)
		Lipin_mid	562..671	CDD:293481	12/108 (11%)
		LNS2	760..985	CDD:285447	122/237 (51%)
PAH1	NP_013888.1	SMP2	1..609	CDD:227415	262/1030 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346287
Domainoid	1	1.000	226	1.000	Domainoid score	I430
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I416
Isobase	1	0.950	-	0	Normalized mean entropy	S3103
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001100
OrthoInspector	1	1.000	-	-		oto99638
orthoMCL	1	0.900	-	-		OOG6_100990
Panther	1	1.100	-	-	LDO	PTHR12181
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R805
SonicParanoid	1	1.000	-	-		X664
TreeFam	1	0.960	-	-
	14	13.730