Protein Alignment Lpin and PITPNM3

DIOPT Version :9

• Sequence 1: NP_001188884.1
• Gene: Lpin / 35790
• FlyBaseID: FBgn0263593
• Length: 1089
• Species: Drosophila melanogaster
• Sequence 2: NP_112497.2
• Gene: PITPNM3 / 83394
• HGNCID: 21043
• Length: 974
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 216/1076 - (20%)
• Similarity: 346/1076 - (32%)
• Gaps: 358/1076 - (33%)

  Fly    32 VEQRDGEFQCSPFHVRFGKLGVL------RSREKVVDIEINGVPVDIQMKLGD---SGEAFFVEE 87
            ||..|.||..:...:..||..:|      .|.:.|..||..|       ||.:   .|.|.....
Human    28 VESSDDEFFDAREEMAEGKNAILIGMSQWNSNDLVEQIETMG-------KLDEHQGEGTAPCTSS 85

  Fly    88 CLEDEDEEL-PANLATSPIPNSFLASRDKANDTMEDISGVVTDKNASEELLLPLPLPRRNSIDFS 151
            .|:::..|| ..:|.....|      ...:.:..||.......::....:|| |.|...|.:|..
Human    86 ILQEKQRELYRVSLRRQRFP------AQGSIEIHEDSEEGCPQRSCKTHVLL-LVLHGGNILDTG 143

  Fly   152 KEEPKEAVVEGSKFENQVSDYTQRRHTDNTL---------------ERRNLSEKLKEFTTQKIRQ 201
            ..:|.....:...|.:.:...| |.|....|               |..:|...|..::
Human   144 AGDPSCKAADIHTFSSVLEKVT-RAHFPAALGHILIKFVPCPAICSEAFSLVSHLNPYS------ 201

  Fly   202 EWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQIKPDVNLTTVTTSEA 266
                |:|       ...|.|.|:...|        |:|.:...:.:.:|.:        .|..|.
Human   202 ----HDE-------GCLSSSQDHVPLA--------ALPLLAISSPQYQDAV--------ATVIER 239

  Fly   267 TKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAG---------GGDLP-SAETPSLGVSNIDE 321
            ..:|.:...|                 ||..:|.:|         ||.|. .|...|.|.|
Human   240 ANQVYREFLK-----------------SSDGIGFSGQVCLIGDCVGGLLAFDAICYSAGPS---- 283

  Fly   322 GDAPISSATNNNNTSS-------------SNDEQLSAPLVTARTG--DDSPLSEIPHTPTSNPRL 371
            ||:|.||:...:.:|:             ::.::||...:...:|  |:.|...:|...:.:...
Human   284 GDSPASSSRKGSISSTQDTPVAVEEDCSLASSKRLSKSNIDISSGLEDEEPKRPLPRKQSDSSTY 348

  Fly   372 DLDI----HFFSDT--------EITTPVGGGGAGSGRAAGGRPSTPIQSDSELETTMRD------ 418
            |.:.    |.|..:        |..||..||           |..|..|....:..:.|
Human   349 DCEAITQHHAFLSSIHSSVLKDESETPAAGG-----------PQLPEVSLGRFDFDVSDFFLFGS 402

  Fly   419 -------NRHVVTEESTASWKWGELPTPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRK 476
                   .|..|            ||        .:...||:.:     .|.::||
Human   403 PLGLVLAMRRTV------------LP--------GLDGFQVRPA-----CSQVYSF--------- 433

  Fly   477 EKGVGEVGDIYLSDLDAGSMDPEMAALYFPSPLSKAASPPEEDGESGNGTSL-------PHSPSS 534
                     .:.:|..|..::|.:...:...|  ..:.|..:....|:|.||       .|||..
Human   434 ---------FHCADPSASRLEPLLEPKFHLVP--PVSVPRYQRFPLGDGQSLLLADALHTHSPLF 487

  Fly   535 LEEGQKSIDSDFDETKQQRDNNRYLDFVAMSMCGMSEQGAPPSDEEFDR----------HLVNYP 589
            ||             ...||:...||..|          :||....|.|          |
Human   488 LE-------------GSSRDSPPLLDAPA----------SPPQASRFQRPGRRMSEGSSH----- 524

  Fly   590 DVCKSPSIFSSPNL----VVRLNGKYY-----TWMAACPIVMTMI-TFQKP-LTH-------DAI 636
                |.|..||.::    ..|:..|::     .:...||.|:|.. |...| |.|       |.:
Human   525 ----SESSESSDSMAPVGASRITAKWWGSKRIDYALYCPDVLTAFPTVALPHLFHASYWESTDVV 585

  Fly   637 EQLMSQTVDGKCLPGDEKQEAV-----AQADNGG---QTKRYWWSWRRSQ----DAAPNHLNNTH 689
            ..::.|.:         :.|:|     |:.|...   ...|..|..:|:|    :...||..|
Human   586 AFILRQVM---------RYESVNIKESARLDPAALSPANPREKWLRKRTQVKLRNVTANHRAN-- 639

  Fly   690 GMPLGKD---EKDGDQAAVATQTSRPTSPDITDPTLSKSDSLVNAENTSALVDNLE-ELTMASNK 750
                  |   .:||.|..|......|.  |:...|..|.|.||.||.:|....:|: |:|.:|.:
Human   640 ------DVIAAEDGPQVLVGRFMYGPL--DMVALTGEKVDILVMAEPSSGRWVHLDTEITNSSGR 696

  Fly   751 --SDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRC-KCYLFRWKHNDKVVISD 812
              .:.|:.|               .|..|:    :.|....:|...| ..||.......:.|:..
Human   697 ITYNVPRPR---------------RLGVGV----YPVKMVVRGDQTCAMSYLTVLPRGMECVVFS 742

  Fly   813 IDGTITKSDVLGHILPMVGKD-WAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYL--RSI 874
            |||:...|      :.::|.| ..:.|...:....:..||.:||::.|...|.:....:|  .:.
Human   743 IDGSFAAS------VSIMGSDPKVRPGAVDVVRHWQDLGYMILYITGRPDMQKQRVVSWLSQHNF 801

  Fly   875 RQGNVMLPDGPLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDLFPDKEPFYAGYGNRINDVW 939
            .||.:...|| |:.:|....:.|.|.::::        |...|.          |.||: ..|:.
Human   802 PQGMIFFSDG-LVHDPLRQKAIFLRNLMQE--------CFIKIS----------AAYGS-TKDIS 846

  Fly   940 AYRAVGIPIMRIFTIN--TKGELKHELTQTFQSSGY 973
            .|..:|:|..:||.:.  ||   |::....|.|.||
Human   847 VYSVLGLPASQIFIVGRPTK---KYQTQCQFLSEGY 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436	21/80 (26%)
		Lipin_mid	562..671	CDD:293481	27/144 (19%)
		LNS2	760..985	CDD:285447	48/220 (22%)
PITPNM3	NP_112497.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..304		6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..346		4/22 (18%)
		DDHD	393..593	CDD:280937	50/276 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..536		14/63 (22%)
		LNS2	739..869	CDD:197870	37/158 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	927..974

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900