DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpin and PAH1

DIOPT Version :9

Sequence 1:	NP_001188884.1	Gene:	Lpin / 35790	FlyBaseID:	FBgn0263593	Length:	1089	Species:	Drosophila melanogaster
Sequence 2:	NP_001118604.1	Gene:	PAH1 / 820113	AraportID:	AT3G09560	Length:	904	Species:	Arabidopsis thaliana

Alignment Length:	1024	Identity:	286/1024 - (27%)
Similarity:	437/1024 - (42%)	Gaps:	213/1024 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GAIDVIVVEQRDGEFQCSPFHVRFGKL-GVLRSREKVVDIEINGVPVDIQMKLGDSGEAFFVEEC 88
            ||||||||:|:||.|:.:|::|||||. |||:..||.|.|.:||...|..|.|.:||||:|:.|.
plant    27 GAIDVIVVQQQDGSFRSTPWYVRFGKFQGVLKGAEKFVRISVNGTEADFHMYLDNSGEAYFIREV 91

  Fly    89 LEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDKNASE--ELLLPLP-LPR------ 144
                  :..||...:.|..|...:.::.|.....:...::|....|  |...||. |.|
plant    92 ------DPAANDTNNLISGSENNNGNQNNGVTYRLEHSLSDSGTGELREGFDPLSRLERTESDCN 150

  Fly   145 RNSIDFSKEEPKEAVVEGS-KFEN-QVSDYTQRRHTDNTL-------------------ERRNLS 188
            |...||..:.|......|| :|:| .|..|...:.:|:.:                   |..||.
plant   151 RRFYDFQDDPPSPTSEYGSARFDNLNVESYGDSQGSDSEVVLVSIDGHILTAPVSVAEQEAENLR 215

  Fly   189 EKLKEF-TTQKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQI 252
            ....:| .......|:.|....|...:.|.|::.:|...::|:.|.........|.|...:.|..
plant   216 LNTPQFHLAPGDGTEFCEGNTEFASSETPWDTEYIDKVEESSDTANIASDKVDAINDERNDLDSH 280

  Fly   253 KPDVNLTTVTTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVS 317
            ..|      ...:.:.:..:.......::|::.|.::  |..|...|            |:....
plant   281 SRD------NAEKDSHDAERDLLGSCLEQSELTKTSE--NVKSEEPG------------PTFEDR 325

  Fly   318 NIDEGDAPISSATNNNNTSSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPRLDLDIHFFSDTE 382
            |:.||:.|:.:...|:.   |.||      ||..:.|    :.:....:|..::.::       |
plant   326 NLKEGEFPLRTIMENDR---SEDE------VTIESID----TLVDSFESSTTQITIE-------E 370

  Fly   383 ITTPVGGGGAGSGRAAGGRPSTPIQSDSE-------LETTMRDNRHVVTEESTASWKWGELPTPE 440
            :.|           ..|.|.|....:|||       .||.:..|    .:||:.|   .:.....
plant   371 VKT-----------TEGSRISVDSNADSECKDEQTSAETAILFN----NQESSIS---VDSNADS 417

  Fly   441 QAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIYLSDLDAGSMDPEMAALYF 505
            :.|:|     |.:.|...::|.|           .:|.|:.|..|   .|.:..|:|
plant   418 ECKDE-----QPRISAETAILIN-----------NQEGGIIESED---QDSERVSID-------- 455

  Fly   506 PSPLSKAASPPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNNRYLDFVAMSMC--- 567
                 ......::|.|...........||::||:...|..::                :|:|
plant   456 -----STREEVDKDNEDRKTVVSVGVTSSVDEGEPDTDQRYE----------------LSLCKDE 499

  Fly   568 ---GMSEQGAPPSDEEFDRHLVNYPDVCKS-PSIFSSPNLVVRLNGKYYTWMAACPIVMTMITFQ 628
               ||   |...:.|.||.|:::..:...| .||..|.|||||:...|..|..|..||:....|.
plant   500 LRQGM---GLSAAAEVFDAHMISKEEYINSATSILESENLVVRIRETYMPWTKAARIVLGKAVFD 561

  Fly   629 KPL---THDAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYW-WSWRRSQDAAPNHLNNTH 689
            ..|   ..|.|      :|:....|..:..|......:.|...|.| ..:||.:.......|::.
plant   562 LDLDIQPDDVI------SVEENESPKPKDDETTITPSSSGTRWRLWPIPFRRVKTVEHTGSNSSS 620

  Fly   690 GMPLGKDEKDGDQAAVATQTSRPTSPDITDPTLSKSDSLVNAENTSALVDNLEELTMASNKSDEP 754
            ...|..|.:.|.|          .||:....|.|:.:|                          |
plant   621 EEDLFVDSEPGLQ----------NSPETQSTTESRHES--------------------------P 649

  Fly   755 KERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVISDIDGTITK 819
            :.:..::...::..|..||||:|.|.|.||.:|...||.:...:::||:.:.|:||||:||||||
plant   650 RRQLVRTNVPTNEQIASLNLKDGQNMITFSFSTRVLGTQQVDAHIYRWRWDTKIVISDVDGTITK 714

  Fly   820 SDVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYLRSIRQGNVMLPDG 884
            |||||..:|.:||||.|.|||:|||.|::|||:||:||||||.|:.:||.:|.:::|....||.|
plant   715 SDVLGQFMPFIGKDWTQSGVAKLFSAIKENGYQLLFLSARAIVQAYLTRNFLNNLKQDGKALPTG 779

  Fly   885 PLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDLFP-DKEPFYAGYGNRINDVWAYRAVGIPI 948
            |::::|..|..|.:||||.:.|.:||||||.|||.||| |..|||||:|||..|..:||.:|||.
plant   780 PVVISPDGLFPALYREVIRRAPHEFKIACLEDIRKLFPTDYNPFYAGFGNRDTDELSYRKLGIPK 844

  Fly   949 MRIFTINTKGELK--HELTQTFQSSGYINQSLEVDEYFPLLTNQDEFDY 995
            .:||.||.|||:.  |.:.   ....|.:....|::.||..:..::.||
plant   845 GKIFIINPKGEVATGHRID---VKKSYTSLHTLVNDMFPPTSLVEQEDY 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436	38/78 (49%)
		Lipin_mid	562..671	CDD:293481	32/118 (27%)
		LNS2	760..985	CDD:285447	109/227 (48%)
PAH1	NP_001118604.1	Lipin_N	1..105	CDD:282436	39/83 (47%)
		Lipin_mid	492..598	CDD:293481	31/130 (24%)
		LNS2	655..880	CDD:285447	109/227 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	220	1.000	Domainoid score	I722
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	284	1.000	Inparanoid score	I859
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D866929at2759
OrthoFinder	1	1.000	-	-		FOG0001100
OrthoInspector	1	1.000	-	-		otm3455
orthoMCL	1	0.900	-	-		OOG6_100990
Panther	1	1.100	-	-	O	PTHR12181
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X664
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830