DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpin and lpin1a

DIOPT Version :9

Sequence 1:	NP_001188884.1	Gene:	Lpin / 35790	FlyBaseID:	FBgn0263593	Length:	1089	Species:	Drosophila melanogaster
Sequence 2:	XP_005158866.1	Gene:	lpin1a / 799099	ZFINID:	ZDB-GENE-080722-2	Length:	920	Species:	Danio rerio

Alignment Length:	1087	Identity:	351/1087 - (32%)
Similarity:	498/1087 - (45%)	Gaps:	284/1087 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPV 70
            :||...::.|..:|.|||:|.||||||.|.||..|||||||||||:||||||||||||||||.||
Zfish    36 QVFVQVKELYRGLNPATLSGCIDVIVVRQPDGTLQCSPFHVRFGKMGVLRSREKVVDIEINGEPV 100

  Fly    71 DIQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNS----FLASRDKANDTMEDISGVVTDKN 131
            .:.||||::||||||:| .||:.|.:|:.||||||.:.    ..|...|....:.: ||    ..
Zfish   101 SLHMKLGENGEAFFVKE-TEDDGEMVPSYLATSPIISEGSALMQAQMGKGTSRLSE-SG----NG 159

  Fly   132 ASEELLLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTT 196
            .:.:.|.|:..|..:||  .|:..|.                :|:...::::|.:..:
Zfish   160 TTIQTLGPMQPPGDSSI--MKKRRKR----------------RRKSKVDSMKREDNGD------- 199

  Fly   197 QKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQIKPDVNLTTV 261
                   :|.|::|     |.|..|.|:.::||...       |:..|
Zfish   200 -------SEDEDMF-----PIDMSSDDDDTEASGSR-------AMSHD----------------- 228

  Fly   262 TTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNIDEGDAPI 326
            ..:|..|..|.:..:..|..:.::.....|..|           ||......|.:|      .|.
Zfish   229 LFAEQLKGASNTYMQSERNWAGVQSTGLEKTCS-----------LPIPTNTGLSIS------CPQ 276

  Fly   327 SSATNNNNTSSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPRLDLDIHFFSDTEITTPVGGGG 391
            .||                  :..||  |||...:|.||
Zfish   277 QSA------------------MFHRT--DSPNGSLPSTP-------------------------- 295

  Fly   392 AGSGRAAGGRPSTPIQSDSELETTMR-----DNRHVVTEESTASWKWGELP-------------- 437
                           :|||||..:.|     ||..::       |.|||||
Zfish   296 ---------------KSDSELLDSQRNKGKPDNPEML-------WTWGELPHAAKPSFRQPLPEP 338

  Fly   438 ---------------------------------TPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMK 469
                                             .|:....||.|.| |::.|..|:::::.:.::
Zfish   339 MVVTPKSIPRSESTHFRAITGDGMVESRGSVMYVPDIRTEEATSTA-VEEVEPISVVAHLITELE 402

  Fly   470 RANR--------------LRKEKGVGEVGD--IYLSDLDAGSMDPEMAALYFPSPLSKAASPPEE 518
            ....              .||:|....:|.  :||.|:.  .::||:||||||......:.....
Zfish   403 DGRHSPGAHAISKTDSPSKRKDKRSPHLGSDGVYLDDIT--ELEPEVAALYFPKSDGATSLRSGA 465

  Fly   519 DGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNNRYLDFVAMSMCGMSEQGAPPSDEEFDR 583
            |..|.|     .||.|:  |...:||..:....|..:   |..:|:|:||...:....:.|||:.
Zfish   466 DSRSAN-----QSPQSV--GSSGMDSGVESFSDQLGD---LPHIAISLCGGLSENREITREEFEE 520

  Fly   584 HLVNYPDVCKSPSIFSSPNLVVRLNGKYYTWMAACPIVMTMITFQKPLTHDAIEQLMSQTVDGKC 648
            ..::|.:...:|:|...|||||::..|||.|..|.|||:.|..|||||....:|.:|.:.:..|
Zfish   521 RAISYQEFADNPAIIDDPNLVVKIGTKYYNWTTAAPIVLAMQVFQKPLPTATVENIMKEKMPKK- 584

  Fly   649 LPGDEKQEAVAQADNGGQTKRYWWSWRRSQDAAPNHLNNTHGMPLGKDEKDGDQAAVATQTSRPT 713
                           ||   |:|:|||....::             |.|...||.....::.|..
Zfish   585 ---------------GG---RWWFSWRGRNSSS-------------KSESAADQIECGDESIRTG 618

  Fly   714 SPD-ITDPTLSKSDSLVNAENTSALVDNLEELTMASNKSDEPKERYKKSLRLSSAAIKKLNLKEG 777
            |.. :.|.:.|..|....|:..:.:  |..|:..:|.     ...|:|:||||...:..||||:|
Zfish   619 SVSRLKDESSSSEDDSGGAKQIAVM--NQPEVLHSSG-----GHCYRKTLRLSPEQLASLNLKDG 676

  Fly   778 MNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVISDIDGTITKSDVLGHILPMVGKDWAQLGVAQL 842
            .|::.|||||.||||.||:..::.|..:||:||||||||||:||.||||||.:||||...|:|:|
Zfish   677 PNDVVFSVTTQYQGTCRCEGTIYLWNWDDKIVISDIDGTITRSDTLGHILPTLGKDWTHQGIARL 741

  Fly   843 FSKIEQNGYKLLYLSARAIGQSRVTREYLRSIRQGNVMLPDGPLLLNPTSLISAFHREVIEKKPE 907
            :.::.|||||.:|.||||||.:.:||.||..:.:...|||.||:||:|:||.|||||||||||||
Zfish   742 YHRVSQNGYKFMYCSARAIGMADMTRGYLHWVNERGTMLPMGPVLLSPSSLFSAFHREVIEKKPE 806

  Fly   908 QFKIACLSDIRDLF-PDKEPFYAGYGNRINDVWAYRAVGIPIMRIFTINTKGELKHELTQTFQSS 971
            :|||.||:||::|| |:.|||||.:|||..||::|:.||:|:.||||:|.||||..|..:| ..|
Zfish   807 KFKIECLTDIKNLFYPNAEPFYAAFGNRATDVYSYKEVGVPLNRIFTVNPKGELIQEHAKT-NIS 870

  Fly   972 GYINQSLEVDEYFPLLTNQDEFDYR-TDIFDD----EESEEELQFSD 1013
            .|......||..||||...:..|:. :|.|..    .|...|::..|
Zfish   871 SYGRLCEVVDHVFPLLIRGNTTDFPCSDTFSQFTFWREQLPEVEKQD 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436	63/96 (66%)
		Lipin_mid	562..671	CDD:293481	35/108 (32%)
		LNS2	760..985	CDD:285447	128/225 (57%)
lpin1a	XP_005158866.1	Lipin_N	27..132	CDD:282436	63/96 (66%)
		Lipin_mid	499..589	CDD:293481	35/108 (32%)
		LNS2	659..884	CDD:285447	128/225 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583812
Domainoid	1	1.000	275	1.000	Domainoid score	I1716
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1344
OMA	1	1.010	-	-		QHG51957
OrthoDB	1	1.010	-	-		D405645at33208
OrthoFinder	1	1.000	-	-		FOG0001100
OrthoInspector	1	1.000	-	-		otm26094
orthoMCL	1	0.900	-	-		OOG6_100990
Panther	1	1.100	-	-	O	PTHR12181
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R805
SonicParanoid	1	1.000	-	-		X664
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800