DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpin and LPIN3

DIOPT Version :9

Sequence 1:	NP_001188884.1	Gene:	Lpin / 35790	FlyBaseID:	FBgn0263593	Length:	1089	Species:	Drosophila melanogaster
Sequence 2:	XP_011527298.1	Gene:	LPIN3 / 64900	HGNCID:	14451	Length:	908	Species:	Homo sapiens

Alignment Length:	1107	Identity:	350/1107 - (31%)
Similarity:	472/1107 - (42%)	Gaps:	335/1107 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPVD 71
            ||...::.|..:|.|||:|.|||:||:|.||.|:||||||||||||||||||||||||:||.|||
Human    11 VFGTVKELYRGLNPATLSGGIDVLVVKQVDGSFRCSPFHVRFGKLGVLRSREKVVDIELNGEPVD 75

  Fly    72 IQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDKNASEEL 136
            :.||||||||||||:| ||.:||.:|..|.|||||             ...:||..:|....
Human    76 LHMKLGDSGEAFFVQE-LESDDEHVPPGLCTSPIP-------------WGGLSGFPSDSQLG--- 123

  Fly   137 LLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTTQKIRQ 201
                          :..||:..|:.|:.       .|.||.     .||....|.||
Human   124 --------------TASEPEGLVMAGTA-------STGRRK-----RRRRRKPKQKE-------- 154

  Fly   202 EWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAI----PAVIEDTEKEKDQIK--------- 253
                       :....||...:.::.|.:|....:.:    |..::..||...|.|
Human   155 -----------DAVATDSSPEELEAGAESELSLPEKLRPEPPGSVQLEEKSSLQPKDIYPYSDGE 208

  Fly   254 --PDVNLT----TVTTSEATKEVSKSKTKKRRKKSQMK---------KNAQRKNSSSSSLGSAGG 303
              |..:|:    |...|::..||...:....|.:|.|:         ..|:|..||....|.||.
Human   209 WPPQASLSAGELTSPKSDSELEVRTPEPSPLRAESHMQWAWGRLPKVARAERPESSVVLEGRAGA 273

  Fly   304 GDLP--SAETPSLGVSNIDEGDAPISSATNNNNTSSSNDEQLSAPLVTARTGDD-SPLSEIPHTP 365
            ...|  ...|||..|:.   |..|                 |..|:.....|.| .|
Human   274 TSPPRGGPSTPSTSVAG---GVDP-----------------LGLPIQQTEAGADLQP-------- 310

  Fly   366 TSNPRLDLDIHFFSDTEITTPVGGGGAGSGRAAGGRPSTPIQSDSELETTMRDNRHVVTEESTAS 430
                          |||..|.||               .|:.:....|:..:.:..:....::.|
Human   311 --------------DTEDPTLVG---------------PPLHTPETEESKTQSSGDMGLPPASKS 346

  Fly   431 WKWG--ELPTPE-QAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIYLSDLD 492
            |.|.  |:|.|. |.:..:......::|:|                      :|. .||||.||.
Human   347 WSWATLEVPVPTGQPERVSRGKGSPKRSQH----------------------LGP-SDIYLDDLP 388

  Fly   493 AGSMDPEMAALYFPSPLSKAASPPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNN- 556
              |:|.|.||||||            ..:||.|......|||    |||:          ||.|
Human   389 --SLDSENAALYFP------------QSDSGLGARRWSEPSS----QKSL----------RDPNP 425

  Fly   557 --------RYLDFVAMSMCGMSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYT 613
                    ..:|.:|:|:||........|.|:|::|.|:|.|:.|:|.:...|||||::|||:|.
Human   426 EHEPEPTLDTVDTIALSLCGGLADSRDISLEKFNQHSVSYQDLTKNPGLLDDPNLVVKINGKHYN 490

  Fly   614 WMAACPIVMTMITFQKPLTHDAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQ 678
            |..|.|:::::..|||.|....:::|..:.:..|                ||   |:|:||||..
Human   491 WAVAAPMILSLQAFQKNLPKSTMDKLEREKMPRK----------------GG---RWWFSWRRRD 536

  Fly   679 DAAPNHLNNTHGMPLGKDEKDGDQAAV-ATQTSRPTSPDITD-PTLSKSDSLVNAENTSALVDNL 741
            ..|..  .:.........|:.|::..| ::....|.||.|.: |:|..|
Human   537 FLAEE--RSAQKEKTAAKEQQGEKTEVLSSDDDAPDSPVILEIPSLPPS---------------- 583

  Fly   742 EELTMASNKSDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHND 806
               |..|..:      |||||||||..|::|||:||.|::.|||||.||||.|||..::.||.:|
Human   584 ---TPPSTPT------YKKSLRLSSDQIRRLNLQEGANDVVFSVTTQYQGTCRCKATIYLWKWDD 639

  Fly   807 KVVISDIDGTITKSDVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARA----------- 860
            |||||||||||||||.||||||.:||||...|:..|:.||:.....||..|.|.
Human   640 KVVISDIDGTITKSDALGHILPQLGKDWTHQGITSLYHKIQLIRAHLLACSRRGGPLHPGPPRPQ 704

  Fly   861 -------------------------------IGQSRVTREYLRSIRQGNVMLPDG------PLLL 888
                                           .||:: .||     ..|..::.||      ||..
Human   705 DSVHRPAESTAWPFSSSPLPAKVGTSESHSWAGQAK-ARE-----TDGGWLVSDGSMPPCPPLSE 763

  Fly   889 NPTSLISA--------------FHREVIEKKPEQFKIACLSDIRDLF-PDKEPFYAGYGNRINDV 938
            ..||..:|              ...||||||||.||:||||||:.|| |..:||||.:|||.|||
Human   764 MGTSSCTARRGPLAWRTSPRGTCSGEVIEKKPEVFKVACLSDIQQLFLPHGQPFYAAFGNRPNDV 828

  Fly   939 WAYRAVGIPIMRIFTINTKGELKHELTQTFQSSGYINQSLEVDEYFPLLTNQDEFDYRTDIFDDE 1003
            :|||.||:|..||||:|.:|||..||.:..:|: |......|:..||.:.....    ||:.:.|
Human   829 FAYRQVGLPESRIFTVNPRGELIQELIKNHKST-YERLGEVVELLFPPVARGPS----TDLANPE 888

  Fly  1004 ES 1005
            .|
Human   889 YS 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436	65/95 (68%)
		Lipin_mid	562..671	CDD:293481	34/108 (31%)
		LNS2	760..985	CDD:285447	122/287 (43%)
LPIN3	XP_011527298.1	Lipin_N	1..106	CDD:282436	65/95 (68%)
		Lipin_mid	439..529	CDD:293481	34/108 (31%)
		LNS2	593..874	CDD:285447	122/287 (43%)
		AF1Q	868..>907	CDD:259154	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149663
Domainoid	1	1.000	273	1.000	Domainoid score	I1791
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1286
Isobase	1	0.950	-	0	Normalized mean entropy	S3103
OMA	1	1.010	-	-		QHG51957
OrthoDB	1	1.010	-	-		D405645at33208
OrthoFinder	1	1.000	-	-		FOG0001100
OrthoInspector	1	1.000	-	-		otm41350
orthoMCL	1	0.900	-	-		OOG6_100990
Panther	1	1.100	-	-	LDO	PTHR12181
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R805
SonicParanoid	1	1.000	-	-		X664
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750