Protein Alignment Lpin and LPIN3

DIOPT Version :10

• Sequence 1: NP_610359.2
• Gene: Lpin / 35790
• FlyBaseID: FBgn0263593
• Length: 1089
• Species: Drosophila melanogaster
• Sequence 2: XP_011527298.1
• Gene: LPIN3 / 64900
• HGNCID: 14451
• Length: 908
• Species: Homo sapiens
• Alignment Length: 1107
• Identity: 350/1107 - (31%)
• Similarity: 472/1107 - (42%)
• Gaps: 335/1107 - (30%)

  Fly     7 VFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPVD 71
            ||...::.|..:|.|||:|.|||:||:|.||.|:||||||||||||||||||||||||:||.|||
Human    11 VFGTVKELYRGLNPATLSGGIDVLVVKQVDGSFRCSPFHVRFGKLGVLRSREKVVDIELNGEPVD 75

  Fly    72 IQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDKNASEEL 136
            :.||||||||||||:| ||.:||.:|..|.|||||             ...:||..:|....
Human    76 LHMKLGDSGEAFFVQE-LESDDEHVPPGLCTSPIP-------------WGGLSGFPSDSQLG--- 123

  Fly   137 LLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTTQKIRQ 201
                          :..||:..|:.|:.       .|.||.     .||....|.||
Human   124 --------------TASEPEGLVMAGTA-------STGRRK-----RRRRRKPKQKE-------- 154

  Fly   202 EWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAI----PAVIEDTEKEKDQIK--------- 253
                       :....||...:.::.|.:|....:.:    |..::..||...|.|
Human   155 -----------DAVATDSSPEELEAGAESELSLPEKLRPEPPGSVQLEEKSSLQPKDIYPYSDGE 208

  Fly   254 --PDVNLT----TVTTSEATKEVSKSKTKKRRKKSQMK---------KNAQRKNSSSSSLGSAGG 303
              |..:|:    |...|::..||...:....|.:|.|:         ..|:|..||....|.||.
Human   209 WPPQASLSAGELTSPKSDSELEVRTPEPSPLRAESHMQWAWGRLPKVARAERPESSVVLEGRAGA 273

  Fly   304 GDLP--SAETPSLGVSNIDEGDAPISSATNNNNTSSSNDEQLSAPLVTARTGDD-SPLSEIPHTP 365
            ...|  ...|||..|:.   |..|                 |..|:.....|.| .|
Human   274 TSPPRGGPSTPSTSVAG---GVDP-----------------LGLPIQQTEAGADLQP-------- 310

  Fly   366 TSNPRLDLDIHFFSDTEITTPVGGGGAGSGRAAGGRPSTPIQSDSELETTMRDNRHVVTEESTAS 430
                          |||..|.||               .|:.:....|:..:.:..:....::.|
Human   311 --------------DTEDPTLVG---------------PPLHTPETEESKTQSSGDMGLPPASKS 346

  Fly   431 WKWG--ELPTPE-QAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIYLSDLD 492
            |.|.  |:|.|. |.:..:......::|:|                      :|. .||||.||.
Human   347 WSWATLEVPVPTGQPERVSRGKGSPKRSQH----------------------LGP-SDIYLDDLP 388

  Fly   493 AGSMDPEMAALYFPSPLSKAASPPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNN- 556
              |:|.|.||||||            ..:||.|......|||    |||:          ||.|
Human   389 --SLDSENAALYFP------------QSDSGLGARRWSEPSS----QKSL----------RDPNP 425

  Fly   557 --------RYLDFVAMSMCGMSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYT 613
                    ..:|.:|:|:||........|.|:|::|.|:|.|:.|:|.:...|||||::|||:|.
Human   426 EHEPEPTLDTVDTIALSLCGGLADSRDISLEKFNQHSVSYQDLTKNPGLLDDPNLVVKINGKHYN 490

  Fly   614 WMAACPIVMTMITFQKPLTHDAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQ 678
            |..|.|:::::..|||.|....:::|..:.:..|                ||   |:|:||||..
Human   491 WAVAAPMILSLQAFQKNLPKSTMDKLEREKMPRK----------------GG---RWWFSWRRRD 536

  Fly   679 DAAPNHLNNTHGMPLGKDEKDGDQAAV-ATQTSRPTSPDITD-PTLSKSDSLVNAENTSALVDNL 741
            ..|..  .:.........|:.|::..| ::....|.||.|.: |:|..|
Human   537 FLAEE--RSAQKEKTAAKEQQGEKTEVLSSDDDAPDSPVILEIPSLPPS---------------- 583

  Fly   742 EELTMASNKSDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHND 806
               |..|..:      |||||||||..|::|||:||.|::.|||||.||||.|||..::.||.:|
Human   584 ---TPPSTPT------YKKSLRLSSDQIRRLNLQEGANDVVFSVTTQYQGTCRCKATIYLWKWDD 639

  Fly   807 KVVISDIDGTITKSDVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARA----------- 860
            |||||||||||||||.||||||.:||||...|:..|:.||:.....||..|.|.
Human   640 KVVISDIDGTITKSDALGHILPQLGKDWTHQGITSLYHKIQLIRAHLLACSRRGGPLHPGPPRPQ 704

  Fly   861 -------------------------------IGQSRVTREYLRSIRQGNVMLPDG------PLLL 888
                                           .||:: .||     ..|..::.||      ||..
Human   705 DSVHRPAESTAWPFSSSPLPAKVGTSESHSWAGQAK-ARE-----TDGGWLVSDGSMPPCPPLSE 763

  Fly   889 NPTSLISA--------------FHREVIEKKPEQFKIACLSDIRDLF-PDKEPFYAGYGNRINDV 938
            ..||..:|              ...||||||||.||:||||||:.|| |..:||||.:|||.|||
Human   764 MGTSSCTARRGPLAWRTSPRGTCSGEVIEKKPEVFKVACLSDIQQLFLPHGQPFYAAFGNRPNDV 828

  Fly   939 WAYRAVGIPIMRIFTINTKGELKHELTQTFQSSGYINQSLEVDEYFPLLTNQDEFDYRTDIFDDE 1003
            :|||.||:|..||||:|.:|||..||.:..:|: |......|:..||.:.....    ||:.:.|
Human   829 FAYRQVGLPESRIFTVNPRGELIQELIKNHKST-YERLGEVVELLFPPVARGPS----TDLANPE 888

  Fly  1004 ES 1005
            .|
Human   889 YS 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_610359.2	Lipin_N	1..104	CDD:461356	66/96 (69%)
		Lipin_mid	562..674	CDD:465292	35/111 (32%)
		LNS2	760..985	CDD:462403	122/287 (43%)
LPIN3	XP_011527298.1	Lipin_N	1..107	CDD:461356	66/96 (69%)
		Lipin_mid	439..532	CDD:465292	35/111 (32%)
		LNS2	593..874	CDD:462403	122/287 (43%)