Protein Alignment Lpin and Lpin3

DIOPT Version :10

• Sequence 1: NP_610359.2
• Gene: Lpin / 35790
• FlyBaseID: FBgn0263593
• Length: 1089
• Species: Drosophila melanogaster
• Sequence 2: NP_075021.1
• Gene: Lpin3 / 64899
• MGIID: 1891342
• Length: 848
• Species: Mus musculus
• Alignment Length: 1020
• Identity: 350/1020 - (34%)
• Similarity: 492/1020 - (48%)
• Gaps: 221/1020 - (21%)

  Fly     7 VFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPVD 71
            ||...::.|..:|.|||:|.|||:||.||||.|:|||||||||||||||||||||||||||.|||
Mouse    11 VFGTVKELYRGLNPATLSGGIDVLVVRQRDGSFRCSPFHVRFGKLGVLRSREKVVDIEINGEPVD 75

  Fly    72 IQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDKNASEEL 136
            :.||||||||||||:| |:.::|::|..|.|||||             ...:||..:|....
Mouse    76 LHMKLGDSGEAFFVQE-LDSDEEDVPPRLCTSPIP-------------WGGLSGFPSDSQIG--- 123

  Fly   137 LLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTTQKIRQ 201
                          :..||:..|:.|            ||......:.|...|...:.:::::
Mouse   124 --------------TASEPEGLVITG------------RRKRRRRRKPRRREEDAVDSSSEEL-- 160

  Fly   202 EWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKD-QIKPDVNLTT----V 261
            |.....||...||...:|.|       :.|||...:.|   :|.....| :..|..||::    .
Mouse   161 EAGAESELTLLEKPTPESPS-------AQEAEEPSSQP---KDIHPYSDGECTPQANLSSGDLMS 215

  Fly   262 TTSEATKEVSKSKTKKRRKKSQMK-------KNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNI 319
            ..|::..|:...:....|.:|.|:       |.|:.:....|.:          .|:.:..:..:
Mouse   216 PKSDSELELRSLEPSPLRAESHMQWVWGRLPKVAKAERPEFSLI----------LESMAEAICAL 270

  Fly   320 DEGDAPISSATNNNNTSSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPRLDLDIHFFSDTEIT 384
            .|..:|.||      .|.:..:.||.|::......|          |.:|.::...   .:|.:
Mouse   271 PEEPSPSSS------PSEAGVDTLSPPVLHPGVRAD----------TFHPAVEAHC---EETAV- 315

  Fly   385 TPVGGGGAGSGRAAGGRPSTPIQSDSELETTMRDNRHVVTEESTASWKWGELPTPEQAKNEAMSA 449
                              .:|:.:....||..:::|......:|.||.|   .|||  .:.....
Mouse   316 ------------------DSPLAAPESKETKTQNSRGAGHPPATKSWSW---TTPE--SHTPSGH 357

  Fly   450 AQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIYLSDLDAGSMDPEMAALYFPSPLSKAAS 514
            .||.:.:               ..|::.:.:|. .||||.||.  |:|.|..|||||.
Mouse   358 PQVSRGK---------------GSLKRNQHLGP-SDIYLDDLP--SLDSENVALYFPK------- 397

  Fly   515 PPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDE--TKQQRDNNRYLDFVAMSMCGMSEQGAPPS 577
                 .|.|.|......||:    ||.::|...|  .:...|:   :|.:.:|:||........|
Mouse   398 -----SEYGMGARRWSEPSN----QKLLESPNPEHIAECTLDS---VDKIELSLCGGLADNRDIS 450

  Fly   578 DEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYTWMAACPIVMTMITFQKPLTHDAIEQLMSQ 642
            .|:|.:|:|:|.|:.|:|.:...|||||::|.|:|.|..|.|:::::..|||.|....:::|..:
Mouse   451 LEKFTQHMVSYEDLTKNPGLLDDPNLVVKINEKHYNWAVAAPMILSLQAFQKNLPESTVDKLEKE 515

  Fly   643 TVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQDAAPNHLNNTHGMPLGKDEKDGDQAAV-A 706
            .:..|                ||   |:|:||||....|..|.:........|.:  |::..| :
Mouse   516 KMPRK----------------GG---RWWFSWRRRDFPAEEHSSQREKAATRKQQ--GEKTEVLS 559

  Fly   707 TQTSRPTSPDITD-PTLSKSDSLVNAENTSALVDNLEELTMASNKSDEPKERYKKSLRLSSAAIK 770
            :....|.||.|.: |.|..|        |...|..                 |||||||||..|:
Mouse   560 SDDDVPDSPVILEVPPLPSS--------TPGYVPT-----------------YKKSLRLSSDQIR 599

  Fly   771 KLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVISDIDGTITKSDVLGHILPMVGKDWA 835
            .|||.||.|::.|||||.||||.|||..::.|..:||||||||||||||||.||||||.:||||.
Mouse   600 CLNLNEGANDVVFSVTTQYQGTCRCKATIYLWNWDDKVVISDIDGTITKSDALGHILPQLGKDWT 664

  Fly   836 QLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYLRSIRQGNVMLPDGPLLLNPTSLISAFHRE 900
            ..|:..|:.||..||||.||.||||||.:.:|:.||:.:.:....||.||:||:|:||.||.|||
Mouse   665 HQGITSLYHKIHLNGYKFLYCSARAIGMADLTKGYLQWVSEHGCGLPKGPILLSPSSLFSALHRE 729

  Fly   901 VIEKKPEQFKIACLSDIRDLF-PDKEPFYAGYGNRINDVWAYRAVGIPIMRIFTINTKGELKHEL 964
            |||||||.||:||||||:.|| |.::||:|.:|||.|||:|||.||:|..||||:|.:|||..||
Mouse   730 VIEKKPEVFKVACLSDIQQLFLPQRQPFHAAFGNRPNDVFAYRQVGLPESRIFTVNPRGELIQEL 794

  Fly   965 TQ----TFQSSGYINQSLEVDEYFPLLTNQDEFDYRTDIFDDEES 1005
            .:    |:|..|.:     |:..||.:.....    ||:...|.|
Mouse   795 IKSHKSTYQRLGEV-----VELLFPPVVRGPS----TDLASPEYS 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_610359.2	Lipin_N	1..104	CDD:461356	66/96 (69%)
		Lipin_mid	562..674	CDD:465292	33/111 (30%)
		LNS2	760..985	CDD:462403	133/229 (58%)
Lpin3	NP_075021.1	N-LIP. /evidence=ECO:0000250	1..108		67/97 (69%)
		Lipin_N	1..107	CDD:461356	66/96 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	97..233		37/189 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	135..144		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..298		8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..373		14/97 (14%)
		Lipin_mid	435..528	CDD:465292	33/111 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..568		5/33 (15%)
		C-LIP. /evidence=ECO:0000250	587..789		126/201 (63%)
		LNS2	589..814	CDD:462403	133/229 (58%)
		DXDXT motif	641..645		3/3 (100%)
		LXXIL motif	652..656		3/3 (100%)