DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpin and lpin2

DIOPT Version :9

Sequence 1:	NP_001188884.1	Gene:	Lpin / 35790	FlyBaseID:	FBgn0263593	Length:	1089	Species:	Drosophila melanogaster
Sequence 2:	XP_005163511.1	Gene:	lpin2 / 558422	ZFINID:	ZDB-GENE-060503-153	Length:	941	Species:	Danio rerio

Alignment Length:	1008	Identity:	352/1008 - (34%)
Similarity:	513/1008 - (50%)	Gaps:	166/1008 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPV 70
            :|....::.|..||.|||:|.|||:||.|:||.:|||||||||||||||||:|||:||||||.||
Zfish    47 QVLVTMKELYKGINQATLSGCIDVVVVRQKDGTYQCSPFHVRFGKLGVLRSKEKVIDIEINGEPV 111

  Fly    71 DIQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDKNASEE 135
            |:.|||||:||||||:| .|:::|.:||:|||||||            |...:..:..|..:|:.
Zfish   112 DLHMKLGDNGEAFFVQE-TEEQNEIVPAHLATSPIP------------TESHLFWIGGDHRSSQN 163

  Fly   136 LLLPLPLPRRNSIDFSKEEPKE---AVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTTQ 197
            |         :......|:|.:   |...|:|.:.:    .:::|..:  .||      :|||..
Zfish   164 L---------DDDPLDPEDPPDRPVASTGGAKKKKK----RRKKHKGD--PRR------EEFTPP 207

  Fly   198 KIRQEWAEHEELFQGEKKPADSDSLDN--QSKASNEAETEKAIPAVIEDTE----KEKDQIKPDV 256
            .:.......:|:|:.:.. :|.|::.|  .|..|...|:|..:|.:....:    .:.|....|.
Zfish   208 AVISSTPSTDEIFEMDLS-SDEDAISNTRSSSVSTVKESEPKLPTIRHSLDSYPYSDGDWSPSDS 271

  Fly   257 NLTTVTTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNIDE 321
            :    ..|||....|.|:...|..:|.:|..:..:.:         .|:.|.    |..||..::
Zfish   272 H----AMSEAFSPKSDSELVVRPSESLLKMESHMQWT---------WGEFPE----STRVSKKEK 319

  Fly   322 GDAPIS-SATNNNNT------SSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPRLDLDIHFFS 379
            .:.|.: :.|.:.||      ||...|          |.:..|.|..|......|
Zfish   320 IELPKTVTITPSENTHFRVILSSEAME----------TDEREPTSGTPSCTIVKP---------- 364

  Fly   380 DTEITTPVGGGGAGSGRAAGGRPSTPIQSDSELETTMRDNRHVVTEESTASWKWGELPTPEQAKN 444
              |..|||             .|.||  ::|||||...:   |:|  ||.|    ::.|......
Zfish   365 --EPRTPV-------------TPKTP--TESELETMPCE---VLT--STPS----DILTAAPTSP 403

  Fly   445 EAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVG------DIYLSDLDAGSMDPEMAAL 503
            .|:|||.:.        .::.....:.:...|:|||.:..      ||||.||:.  ::|::||.
Zfish   404 AAVSAAPLG--------GDIGDVGSKTDSPSKKKGVPKRSQHQGPEDIYLDDLNV--LEPDVAAR 458

  Fly   504 YFPSPLSKAASPPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETKQQRDNNRYLDFVAMSMCG 568
            |||...|.|.|....|....:|:..|.|     .|..:.||.   |:...|:...|..|.:|:||
Zfish   459 YFPKSDSDAGSKHWMDSGMHSGSQSPQS-----VGSAAADSG---TECLSDSASDLPDVTLSLCG 515

  Fly   569 MSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYTWMAACPIVMTMITFQKPLTH 633
            ...:....|.|:|..|::.|.:..::|:|..:.||||::..:||.|..|.|:::::..|||.|..
Zfish   516 GLSENGEISKEKFMEHIITYNEFAENPAIIDNQNLVVKIGNRYYNWTLAAPLILSLQAFQKNLPK 580

  Fly   634 DAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQDAAPNHLNNTHGMPLGKDEK 698
            ...|..:.:.:..|                .|:    ||.||:..|:......:|..:...:.:.
Zfish   581 ATEEAWVKERMPKK----------------SGR----WWFWRKRADSTIKQSESTGKLEAKQSQL 625

  Fly   699 DGDQAAVATQTSRPTSPDITDPTLSKSDSLVNAENTSALVDNLEELTMASNKSDEPKERYKKSLR 763
            :...::::.: |.....|..|   |.||.  ..:..||...::|....:..........|:||||
Zfish   626 EEGSSSLSME-SHARKVDTRD---SSSDE--EGKEVSAAASSMERKIQSEPHGHTSTHSYRKSLR 684

  Fly   764 LSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVISDIDGTITKSDVLGHILP 828
            |||:.|..|.||||.|::.||:||.||||.||:..::.|..:|||:|||||||||||||.|.|||
Zfish   685 LSSSQIASLKLKEGPNDVMFSITTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITKSDVFGQILP 749

  Fly   829 MVGKDWAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYLRSIRQGNVMLPDGPLLLNPTSL 893
            ..||||...|:|:|:..:.:||||.||.||||||.:.:||.||:.:..|.::||.|||:|:|:||
Zfish   750 QFGKDWTHQGIAKLYHSVAENGYKFLYCSARAIGMADMTRGYLQWVNDGGIILPRGPLMLSPSSL 814

  Fly   894 ISAFHREVIEKKPEQFKIACLSDIRDLF-PDKEPFYAGYGNRINDVWAYRAVGIPIMRIFTINTK 957
            .|||||||||||||.|||.||:||::|| |:|.||||.:|||.|||:||:.||:|:.||||:|.|
Zfish   815 FSAFHREVIEKKPEIFKIECLTDIKNLFLPNKHPFYAAFGNRTNDVFAYKEVGVPVCRIFTVNPK 879

  Fly   958 GELKHELTQTFQSSGYINQSLEVDEYFPLLTNQ 990
            |||..|.|:..:|| |...|..||..||||:.:
Zfish   880 GELIQEQTKGNKSS-YSRLSELVDHVFPLLSKE 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436	63/96 (66%)
		Lipin_mid	562..671	CDD:293481	27/108 (25%)
		LNS2	760..985	CDD:285447	134/225 (60%)
lpin2	XP_005163511.1	Lipin_N	38..143	CDD:282436	63/96 (66%)
		Lipin_mid	509..599	CDD:293481	27/109 (25%)
		LNS2	681..906	CDD:285447	134/225 (60%)
		AF1Q	<920..>939	CDD:259154
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583814
Domainoid	1	1.000	275	1.000	Domainoid score	I1716
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1344
OMA	1	1.010	-	-		QHG51957
OrthoDB	1	1.010	-	-		D405645at33208
OrthoFinder	1	1.000	-	-		FOG0001100
OrthoInspector	1	1.000	-	-		otm26094
orthoMCL	1	0.900	-	-		OOG6_100990
Panther	1	1.100	-	-	O	PTHR12181
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R805
SonicParanoid	1	1.000	-	-		X664
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940