DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpin and Pitpnm3

DIOPT Version :9

Sequence 1:	NP_001188884.1	Gene:	Lpin / 35790	FlyBaseID:	FBgn0263593	Length:	1089	Species:	Drosophila melanogaster
Sequence 2:	XP_006533626.1	Gene:	Pitpnm3 / 327958	MGIID:	2685726	Length:	975	Species:	Mus musculus

Alignment Length:	796	Identity:	155/796 - (19%)
Similarity:	255/796 - (32%)	Gaps:	257/796 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 SATNNNNTSSSNDEQLSAPLVTARTGDDSPLSEIPHTPTSNPR--------LDLDIHFFSD---- 380
            |..:|.|..|.::..|..      :.|..||:.:|....|:|:        ::...|.:.:
Mouse   192 SLVSNLNPYSHDEGCLGT------SQDHVPLAALPLLAISSPQYQDAVATVIERANHIYGEFLKS 250

  Fly   381 ----------TEITTPVGG-----------GGAGSGRAAGGR-------PSTP--IQSDSELETT 415
                      ..|...|||           |.:|....:..|       ..||  ::.|..|.::
Mouse   251 SDGIGFNGQVCLIGDCVGGLLAFDAICYSAGPSGDSPGSSSRKGSISSTQDTPVVVEEDCSLASS 315

  Fly   416 MRDNRHVVTEESTASWKWGELPTPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGV 480
            .|.::..|...|....:..:.|.|.:..:.:....:.....|..:.|::.|.:     |:.|...
Mouse   316 KRLSKSNVDVSSGVEDEDPKRPLPRKQSDSSTYDCEAITQHHAFLSSSIHSSV-----LKDEAEA 375

  Fly   481 GEVGDIYLSDLDAGSMDPEMAALY-FPSPLS-----KAASPPEEDG------------------- 520
            ...|...||::..|..|.:::..: |.|||.     :....|..||
Mouse   376 PAAGTPQLSEVSLGRFDFDVSDFFLFGSPLGLVLAMRRTVLPGIDGFQMRPACSQVYSFFHCADP 440

  Fly   521 ---------------------------ESGNGTSL-------PHSPSSLEEGQKSIDSDFDETKQ 551
                                       ..|:|.||       .|||..||             ..
Mouse   441 SASRLEPLLEPKFHLVPPVSVPRYQRFPLGDGQSLLLADALHTHSPLFLE-------------GS 492

  Fly   552 QRDNNRYLDFVAMSMCGMSEQGAPPSDEEFDR----------HLVNYPDVCKSPSIFSSPNL--- 603
            .|.:...||..|          :||....|.|          |         |.|..||.:|
Mouse   493 SRGSPPLLDAPA----------SPPQAPRFQRTERRLSKGSSH---------SDSSESSDSLAPM 538

  Fly   604 -VVRLNGKYY-----TWMAACPIVMTMI-TFQKP-LTH-------DAIEQLMSQTVDGKCLPGDE 653
             ..|:..|::     .:...||.|:|.. |...| |.|       |.:..::.|.:
Mouse   539 GASRITAKWWGTKRIDYALYCPDVLTAFPTVALPHLFHASYWESTDVVAFILRQVM--------- 594

  Fly   654 KQEAVAQADNGG--------QTKRYWWSWRRSQ----DAAPNHLNNTHGMPLGKD---EKDGDQA 703
            :.|:.:..::.|        ...|..|..:|:|    :...||..|        |   .:||.|.
Mouse   595 RYESASVKESTGLDPTALSPANPREKWLRKRTQVKLRNVTANHRAN--------DVIAAEDGPQV 651

  Fly   704 AVATQTSRPTSPDITDPTLSKSDSLVNAENTSALVDNLEELTMASNKSDEPKERYKKSLRLSSAA 768
            .|......|.  |:...|..|.|.||..|.:|....:|:  |..:|.|........:..||....
Mouse   652 LVGRFMYGPL--DMVALTGEKVDILVMTEPSSGRWVHLD--TEITNNSGRITYNVPRPRRLGVGV 712

  Fly   769 IKKLNLKEGMNEIEFSVTTAYQGTTRC-KCYLFRWKHNDKVVISDIDGTITKSDVLGHILPMVGK 832
                          :.|....:|...| ..||.......:.|:..|||:...|      :.::|.
Mouse   713 --------------YPVKMVVRGDQTCAMSYLTVLPRGMECVVFSIDGSFAAS------VSIMGS 757

  Fly   833 D-WAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYL--RSIRQGNVMLPDGPLLLNPTSLI 894
            | ..:.|...:....:..||.:||::.|...|.:....:|  .:..||.:...|| |:.:|....
Mouse   758 DPKVRPGAVDVVRHWQDLGYMILYITGRPDMQKQRVVSWLSQHNFPQGMIFFSDG-LVHDPLRQK 821

  Fly   895 SAFHREVIEKKPEQFKIACLSDIRDLFPDKEPFYAGYGNRINDVWAYRAVGIPIMRIFTI--NTK 957
            :.|.|.::::        |...|.          |.||: ..|:..|..:|:|..:||.:  :||
Mouse   822 AIFLRNLMQE--------CFIKIT----------AAYGS-TKDISVYSVLGLPASQIFIVGRSTK 867

  Fly   958 GELKHELTQTFQSSGY 973
               |::....|.|.||
Mouse   868 ---KYQTQCQFLSEGY 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436
		Lipin_mid	562..671	CDD:293481	26/144 (18%)
		LNS2	760..985	CDD:285447	48/220 (22%)
Pitpnm3	XP_006533626.1	DDHD	394..594	CDD:367219	42/231 (18%)
Pitpnm3	XP_006533626.1	LNS2	740..870	CDD:197870	37/158 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900