Protein Alignment Lpin and LPIN1

DIOPT Version :10

• Sequence 1: NP_610359.2
• Gene: Lpin / 35790
• FlyBaseID: FBgn0263593
• Length: 1089
• Species: Drosophila melanogaster
• Sequence 2: NP_001248357.1
• Gene: LPIN1 / 23175
• HGNCID: 13345
• Length: 975
• Species: Homo sapiens
• Alignment Length: 1051
• Identity: 369/1051 - (35%)
• Similarity: 513/1051 - (48%)
• Gaps: 209/1051 - (19%)

  Fly     6 RVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPV 70
            :||...::.|..:|.|||:|.||:||:.|.:|..|||||||||||:||||||||||||||||..|
Human    59 QVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRSREKVVDIEINGESV 123

  Fly    71 DIQMKLGDSGEAFFVEECLEDEDEE-LPANLATSPIPNSFLASRDKA---NDTMEDISGVVTDKN 131
            |:.|||||:||||||:|  .|.|:| :|.:||||||.:.. |||.:.   ..:::.:.|:  |.:
Human   124 DLHMKLGDNGEAFFVQE--TDNDQEVIPMHLATSPILSEG-ASRMECQLKRGSVDRMRGL--DPS 183

  Fly   132 ASEELLLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTT 196
            ...:::.|...|..:|           ||:..:...:.|.....:..||
Human   184 TPAQVIAPSETPSSSS-----------VVKKRRKRRRKSQLDSLKRDDN---------------- 221

  Fly   197 QKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQIKPDVNLTTV 261
                ...:|.|::|     |.:..|    .:|....|:.:.:|   .|....:|.| |:.||:..
Human   222 ----MNTSEDEDMF-----PIEMSS----DEAMELLESSRTLP---NDIPPFQDDI-PEENLSLA 269

  Fly   262 TTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNIDEGDAPI 326
            .....    |.|.....|:.|....:......::..|..|..|.|.|:..|...:.:..|
Human   270 VIYPQ----SASYPNSDREWSPTPSSLVDCKRTAPHLAVAAEGGLSSSCPPQSSLFHPSE----- 325

  Fly   327 SSATNNNNTSSSNDEQLSAPLVTARTGDDSP-------------LSEIPH-----TPTSNPRLDL 373
            |.:.:..:|..|:.|.:|..  |.|||..:|             .|..||     :|.|:.::..
Human   326 SPSGSRPSTPKSDSELVSKS--TERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICD 388

  Fly   374 DIHF----------FSDTEITTPVGGGGAGSGRAAGGRPSTPIQ--SDSELETTMRDNRHVVTEE 426
            ..||          ||| :..|.|||.....     .:|.|.:|  ::.:|||.
Human   389 KSHFQAIHSESSDTFSD-QSPTLVGGALLDQ-----NKPQTEMQFVNEEDLETL----------- 436

  Fly   427 STASWKWGE----LPTPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIY 487
                   |.    ||..|:.|  ..||:.||.:......|.     ||..|.|.   :|..| :|
Human   437 -------GAAAPLLPMIEELK--PPSASVVQTANKTDSPSR-----KRDKRSRH---LGADG-VY 483

  Fly   488 LSDLDAGSMDPEMAALYF-----PSPLSKAASPPEEDGESGNGT-SLPHSPSSLEEGQKSIDSDF 546
            |.||.  .||||:|||||     ||.|:|.|        |.||. |...||.|:  |...:||..
Human   484 LDDLT--DMDPEVAALYFPKNGDPSGLAKHA--------SDNGARSANQSPQSV--GSSGVDSGV 536

  Fly   547 DETKQQRDNNRYLDFVAMSMCGMSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKY 611
            :.|.   |..|.|..:|:|:||........:.:.|....|:|.....:|:|...|||||::..||
Human   537 ESTS---DGLRDLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKY 598

  Fly   612 YTWMAACPIVMTMITFQKPLTHDAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRR 676
            |.|..|.|:::.|..|||||....:|.:|...:..|                ||   |:|:|||.
Human   599 YNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPKK----------------GG---RWWFSWRG 644

  Fly   677 -----SQDAAPNHLNNTHGMPLGKDEKDGD---QAAVATQTSRPTSPDITDPTLSKSDSLVNAEN 733
                 .:::.|..      ...||....|:   |.::||:....:         |.||.    |.
Human   645 RNTTIKEESKPEQ------CLAGKAHSTGEQPPQLSLATRVKHES---------SSSDE----ER 690

  Fly   734 TSALVDNLEELTMASNKSDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCY 798
            .:|...|...|.:..|.|      |||:|||:|..:|.|.||.|.|::.|||||.||||.||:..
Human   691 AAAKPSNAGHLPLLPNVS------YKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGT 749

  Fly   799 LFRWKHNDKVVISDIDGTITKSDVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARAIGQ 863
            ::.|..:|||:|||||||||:||.||||||.:||||...|:|:|:.|:.|||||.||.||||||.
Human   750 IYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGM 814

  Fly   864 SRVTREYLRSIRQGNVMLPDGPLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDL-FPDKEPF 927
            :.:||.||..:.:...:||.|||||:|:||.||.||||||||||:||:.||:||::| ||:.|||
Human   815 ADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPF 879

  Fly   928 YAGYGNRINDVWAYRAVGIPIMRIFTINTKGELKHELTQTFQSSGYINQSLEVDEYFPLLTNQDE 992
            ||.:|||..||::|:.||:.:.||||:|.||||..|..:| ..|.|:.....||..||||.....
Human   880 YAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKT-NISSYVRLCEVVDHVFPLLKRSHS 943

  Fly   993 FDYR-TDIFDD 1002
            .|:. :|.|.:
Human   944 SDFPCSDTFSN 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_610359.2	Lipin_N	1..104	CDD:461356	62/98 (63%)
		Lipin_mid	562..674	CDD:465292	33/111 (30%)
		LNS2	760..985	CDD:462403	127/225 (56%)
LPIN1	NP_001248357.1	Lipin_N	50..156	CDD:461356	62/98 (63%)
		Lipin_mid	549..642	CDD:465292	33/111 (30%)
		LNS2	711..936	CDD:462403	127/225 (56%)