DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpin and LPIN1

DIOPT Version :9

Sequence 1:	NP_001188884.1	Gene:	Lpin / 35790	FlyBaseID:	FBgn0263593	Length:	1089	Species:	Drosophila melanogaster
Sequence 2:	NP_001248357.1	Gene:	LPIN1 / 23175	HGNCID:	13345	Length:	975	Species:	Homo sapiens

Alignment Length:	1051	Identity:	369/1051 - (35%)
Similarity:	513/1051 - (48%)	Gaps:	209/1051 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPV 70
            :||...::.|..:|.|||:|.||:||:.|.:|..|||||||||||:||||||||||||||||..|
Human    59 QVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRSREKVVDIEINGESV 123

  Fly    71 DIQMKLGDSGEAFFVEECLEDEDEE-LPANLATSPIPNSFLASRDKA---NDTMEDISGVVTDKN 131
            |:.|||||:||||||:|  .|.|:| :|.:||||||.:.. |||.:.   ..:::.:.|:  |.:
Human   124 DLHMKLGDNGEAFFVQE--TDNDQEVIPMHLATSPILSEG-ASRMECQLKRGSVDRMRGL--DPS 183

  Fly   132 ASEELLLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTT 196
            ...:::.|...|..:|           ||:..:...:.|.....:..||
Human   184 TPAQVIAPSETPSSSS-----------VVKKRRKRRRKSQLDSLKRDDN---------------- 221

  Fly   197 QKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKEKDQIKPDVNLTTV 261
                ...:|.|::|     |.:..|    .:|....|:.:.:|   .|....:|.| |:.||:..
Human   222 ----MNTSEDEDMF-----PIEMSS----DEAMELLESSRTLP---NDIPPFQDDI-PEENLSLA 269

  Fly   262 TTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPSLGVSNIDEGDAPI 326
            .....    |.|.....|:.|....:......::..|..|..|.|.|:..|...:.:..|
Human   270 VIYPQ----SASYPNSDREWSPTPSSLVDCKRTAPHLAVAAEGGLSSSCPPQSSLFHPSE----- 325

  Fly   327 SSATNNNNTSSSNDEQLSAPLVTARTGDDSP-------------LSEIPH-----TPTSNPRLDL 373
            |.:.:..:|..|:.|.:|..  |.|||..:|             .|..||     :|.|:.::..
Human   326 SPSGSRPSTPKSDSELVSKS--TERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICD 388

  Fly   374 DIHF----------FSDTEITTPVGGGGAGSGRAAGGRPSTPIQ--SDSELETTMRDNRHVVTEE 426
            ..||          ||| :..|.|||.....     .:|.|.:|  ::.:|||.
Human   389 KSHFQAIHSESSDTFSD-QSPTLVGGALLDQ-----NKPQTEMQFVNEEDLETL----------- 436

  Fly   427 STASWKWGE----LPTPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIY 487
                   |.    ||..|:.|  ..||:.||.:......|.     ||..|.|.   :|..| :|
Human   437 -------GAAAPLLPMIEELK--PPSASVVQTANKTDSPSR-----KRDKRSRH---LGADG-VY 483

  Fly   488 LSDLDAGSMDPEMAALYF-----PSPLSKAASPPEEDGESGNGT-SLPHSPSSLEEGQKSIDSDF 546
            |.||.  .||||:|||||     ||.|:|.|        |.||. |...||.|:  |...:||..
Human   484 LDDLT--DMDPEVAALYFPKNGDPSGLAKHA--------SDNGARSANQSPQSV--GSSGVDSGV 536

  Fly   547 DETKQQRDNNRYLDFVAMSMCGMSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKY 611
            :.|.   |..|.|..:|:|:||........:.:.|....|:|.....:|:|...|||||::..||
Human   537 ESTS---DGLRDLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKY 598

  Fly   612 YTWMAACPIVMTMITFQKPLTHDAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRR 676
            |.|..|.|:::.|..|||||....:|.:|...:..|                ||   |:|:|||.
Human   599 YNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPKK----------------GG---RWWFSWRG 644

  Fly   677 -----SQDAAPNHLNNTHGMPLGKDEKDGD---QAAVATQTSRPTSPDITDPTLSKSDSLVNAEN 733
                 .:::.|..      ...||....|:   |.::||:....:         |.||.    |.
Human   645 RNTTIKEESKPEQ------CLAGKAHSTGEQPPQLSLATRVKHES---------SSSDE----ER 690

  Fly   734 TSALVDNLEELTMASNKSDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCY 798
            .:|...|...|.:..|.|      |||:|||:|..:|.|.||.|.|::.|||||.||||.||:..
Human   691 AAAKPSNAGHLPLLPNVS------YKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGT 749

  Fly   799 LFRWKHNDKVVISDIDGTITKSDVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARAIGQ 863
            ::.|..:|||:|||||||||:||.||||||.:||||...|:|:|:.|:.|||||.||.||||||.
Human   750 IYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGM 814

  Fly   864 SRVTREYLRSIRQGNVMLPDGPLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDL-FPDKEPF 927
            :.:||.||..:.:...:||.|||||:|:||.||.||||||||||:||:.||:||::| ||:.|||
Human   815 ADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPF 879

  Fly   928 YAGYGNRINDVWAYRAVGIPIMRIFTINTKGELKHELTQTFQSSGYINQSLEVDEYFPLLTNQDE 992
            ||.:|||..||::|:.||:.:.||||:|.||||..|..:| ..|.|:.....||..||||.....
Human   880 YAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKT-NISSYVRLCEVVDHVFPLLKRSHS 943

  Fly   993 FDYR-TDIFDD 1002
            .|:. :|.|.:
Human   944 SDFPCSDTFSN 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436	61/97 (63%)
		Lipin_mid	562..671	CDD:293481	32/108 (30%)
		LNS2	760..985	CDD:285447	127/225 (56%)
LPIN1	NP_001248357.1	Lipin_N	50..155	CDD:282436	61/97 (63%)
		Lipin_mid	549..639	CDD:293481	32/108 (30%)
		LNS2	711..936	CDD:285447	127/225 (56%)
		AF1Q	940..>969	CDD:259154	3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149660
Domainoid	1	1.000	273	1.000	Domainoid score	I1791
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1286
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51957
OrthoDB	1	1.010	-	-		D405645at33208
OrthoFinder	1	1.000	-	-		FOG0001100
OrthoInspector	1	1.000	-	-		otm41350
orthoMCL	1	0.900	-	-		OOG6_100990
Panther	1	1.100	-	-	O	PTHR12181
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R805
SonicParanoid	1	1.000	-	-		X664
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800