Protein Alignment Lpin and Pitpnm2

DIOPT Version :9

• Sequence 1: NP_001188884.1
• Gene: Lpin / 35790
• FlyBaseID: FBgn0263593
• Length: 1089
• Species: Drosophila melanogaster
• Sequence 2: XP_006530277.1
• Gene: Pitpnm2 / 19679
• MGIID: 1336192
• Length: 1385
• Species: Mus musculus
• Alignment Length: 1162
• Identity: 207/1162 - (17%)
• Similarity: 351/1162 - (30%)
• Gaps: 422/1162 - (36%)

  Fly   119 TMEDISGVVTDKNASEELLLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLE 183
            |||.|      :....|:.|.|   .|....||:|.|.| :.:.|..::|.|..|....:.|
Mouse   238 TMEKI------RELEREVQLML---SRKMAQFSEEGPSE-LSKDSATKDQASGTTSDPGSKN--- 289

  Fly   184 RRNLSEKLKEFTTQKIRQEWAEHEELFQGEKKPADSDSLDNQSKASNEAETEKAIPAVIEDTEKE 248
                .|.|    .:.::::|:...:..:..|:.|         ..|..:.:|..:.::..|:::.
Mouse   290 ----GEPL----GRGLKKQWSTSSKSSRSSKRGA---------SPSRHSISEWRMQSIARDSDEG 337

  Fly   249 KDQIKPDVNLTTVTTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDL------- 306
            .::...|.:.....|.|   :.:|..||........|..:.....|...:....|.:.
Mouse   338 SEEEFFDAHENLYCTEE---KQAKDMTKWNSNDLMDKMESPEPEESQDEIYQQSGSEFRVASSVE 399

  Fly   307 -----------PSAETPSL---------GVSNIDEGDAPISSATNNNNTSSSNDE---------- 341
                       |.|..||.         |.:.:|.|....||...:.||.::..:
Mouse   400 QLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKQGDTNTITNVFDTVMRVHYPSA 464

  Fly   342 --QLSAPLV-------------------------TARTGDDSPLSEIPHTPTSNPR--------- 370
              .|:..||                         .:.:.|..||:.:|...||:|:
Mouse   465 LGHLAIRLVPCPPICADAFALVSNLSPYGHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVI 529

  Fly   371 ---------------------------------LDLDIHFFS--------------------DTE 382
                                             |..|...:|                    |.:
Mouse   530 QRANLAYGDFIKSQEGVTFNGQVCLIGDCVGGILAFDALCYSGQPVSESQSSSRRGSVVSMQDAD 594

  Fly   383 ITTP----------VGGGGAGSGRAAGGRPSTPIQSDSELETTMRD-NRHVVTEESTASWKWGEL 436
            :.:|          .|.||.|||       .:.::|...|..:..| .|...||:|..     :|
Mouse   595 LLSPGTLANAAHCSGGSGGGGSG-------GSSLESSRHLSRSNIDIPRSNGTEDSRR-----QL 647

  Fly   437 PTPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKE------------KGVG-------E 482
            |. :::.:.......:||  ||:.||::     .|:.||.|            .|.|       |
Mouse   648 PR-KRSDSSTYELDTIQQ--HQAFLSSL-----HASVLRNEPSSRRSSSSTMLDGAGALGKFDFE 704

  Fly   483 VGDIYL----------------SDLDAGSMDP---EMAALYFPS-PLSKAASP------------ 515
            :.|::|                ..||...:.|   ::..|:.|: |.:....|
Mouse   705 IADLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHSLPPF 769

  Fly   516 --------PEEDG-----------------ESGNGTSLPHSPSSLE-----------EGQKS--- 541
                    |..||                 |.|....|||..|.||           :|.:.
Mouse   770 SIPRYQRYPLGDGCSTLLVETVQRNPELVLEGGPLAPLPHGDSFLETSIPVPALTWQDGPRQSLG 834

  Fly   542 -IDSDFDETKQQ-----------------RDNNRYLDF-VAMSMCGMSEQGAPPSDEEFDRHLVN 587
             .:||..:|...                 |...|..:. :|..:.||:|.....|..:.....:|
Mouse   835 CSESDVLQTHNTVFQEHAAPSSPGTAPAGRGFRRASEISIASQVSGMAESYTASSIAQKGPSSLN 899

  Fly   588 YPDVCKSPSIFS------------------SPNL----------VVRLNGKYY-----TWMAACP 619
            :....:..|:.:                  ||||          :..:..|::     .:...||
Mouse   900 HTPSIRRLSLLALPPPSPTTQGPRARARQVSPNLERAPCLPDLDIGEVAAKWWGQKRIDYALYCP 964

  Fly   620 IVMTMI-TFQKP-LTH-------DAIEQLMSQTV---DGKCLPGDEKQEAVAQADNGGQTKRYWW 672
            ..:|.. |...| |.|       |.:..|:.|.:   ....|..|.|:.:|.   ...|.:..|.
Mouse   965 DALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSSSILELDGKEVSVF---TPSQPRERWQ 1026

  Fly   673 SWR---RSQDAAPNHLNNTHGMPLGKDEKDGDQAAVATQTSRPTSPDITDPTLSKSDSLVNAENT 734
            ..|   :.::.|.||..|.     ....:||.|.........|.  |:...|..|.|..:..:..
Mouse  1027 RKRTHVKLRNVAANHRIND-----AVANEDGPQVVTGRFMYGPL--DMVTLTGEKVDVHIMTQPP 1084

  Fly   735 SALVDNLEELTMASNKSDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYL 799
            |....:|:  |:.:|.|.          |:|....:...|..|:..|:..|...:   |....|:
Mouse  1085 SGEWLHLD--TLVTNSSG----------RVSYTIPETHRLGVGVYPIKMVVRGDH---TFADSYI 1134

  Fly   800 FRWKHNDKVVISDIDGTITKSDVLGHILPMVGKD-WAQLGVAQLFSKIEQNGYKLLYLSARAIGQ 863
            .......:.|:..|||:...|      :.::|.| ..:.|...:....:..||.::|::.|...|
Mouse  1135 TVLPRGTEFVVFSIDGSFAAS------VSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQ 1193

  Fly   864 SRVTREYL--RSIRQGNVMLPDGPLLLNPTS--------LISAFHREVIEKKPEQFKIACLSDIR 918
            .:....:|  .:...|.|...|| |:.:|..        |||..|...
Mouse  1194 KQRVVAWLAQHNFPHGVVSFCDG-LVHDPLRHKANFLKLLISELHLRA----------------- 1240

  Fly   919 DLFPDKEPFYAGYGNRINDVWAYRAVGIPIMRIFTINTKGELKHELTQ--TFQSSGY 973
                     :|.||: ..||..|.::.:..|.|:.:   |....:|.|  .|.:.||
Mouse  1241 ---------HAAYGS-TKDVAVYNSISLSPMHIYIV---GRPTKKLQQQCQFITDGY 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436
		Lipin_mid	562..671	CDD:293481	27/153 (18%)
		LNS2	760..985	CDD:285447	46/227 (20%)
Pitpnm2	XP_006530277.1	SRPBCC_PITPNM1-2_like	1..258	CDD:176898	8/28 (29%)
		DDHD	704..998	CDD:367219	49/293 (17%)
		SMP2	<1041..>1190	CDD:227415	34/176 (19%)
		LNS2	1144..1275	CDD:197870	34/167 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900