DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpin and lpin-1

DIOPT Version :9

Sequence 1:	NP_001188884.1	Gene:	Lpin / 35790	FlyBaseID:	FBgn0263593	Length:	1089	Species:	Drosophila melanogaster
Sequence 2:	NP_506380.2	Gene:	lpin-1 / 179853	WormBaseID:	WBGene00010425	Length:	794	Species:	Caenorhabditis elegans

Alignment Length:	1075	Identity:	311/1075 - (28%)
Similarity:	443/1075 - (41%)	Gaps:	358/1075 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSLARVFSNFRDFYNDINAATLTGAIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEI 65
            |:...|||.|.:.|||.||.|||:|||||:||||.:||::.:||||||||.||....:|.|||.:
Worm     1 MDYAYRVFKNVKYFYNSINPATLSGAIDVVVVEQPNGEYKSTPFHVRFGKYGVFSYSDKYVDIAV 65

  Fly    66 NGVPVDIQMKLGDSGEAFFVEECLEDEDEELPANLATSPIPNSFLASRDKANDTMEDISGVVTDK 130
            |||.:|::|||.|||.||||||.    |:::|..|.|||:|.         .:|.: .:|...||
Worm    66 NGVEIDLKMKLADSGVAFFVEEA----DDQVPDYLLTSPLPE---------QETPQ-TAGPAVDK 116

  Fly   131 NASEELLLPLPLPRRNSIDFSKEEPKEAVVEGSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFT 195
            ..:|.                                                    :.||:|
Worm   117 VLAES----------------------------------------------------ARKLEE-- 127

  Fly   196 TQKIRQEWAEHEELFQGEKKPADSDSLD---------NQSKASNEAETEKAIP---AVIEDTEKE 248
            ||.      |:|::...:...:.|.|.|         .|.::.::.:.::.:|   :|..|   .
Worm   128 TQN------ENEDVDMNDIAKSRSSSPDGGQGNAREPKQEQSLSQVQRKQTLPFSSSVFSD---R 183

  Fly   249 KDQIKPDVNLTTVTTSEATKEVSKSKTKKRRKKSQMKKNAQRKNSSSSSLGSAGGGDLPSAETPS 313
            :.:..||:.:....|.....::.||..|:.||                              ||.
Worm   184 RYRSLPDLTVLAAETEVERTDIKKSDGKRTRK------------------------------TPR 218

  Fly   314 LGVSNIDEGDAPISSATNNNNTSSSNDEQLSAPLVTARTGDDS---PL---SEIPHTPTSNPRLD 372
            ..|.:..:     .|.....:...||||.|.:  :...|.|..   ||   |.:.....:...:|
Worm   219 PFVHSHSQ-----CSPMEKKHFHKSNDEILRS--LRRETHDMDRRIPLRKKSRVTFNQQATRPID 276

  Fly   373 LDIHFF--SDTEITTPVGGGGAGS-------GRAAGGRPSTPIQSDSELETTMRDNRHVVTEEST 428
            :.|..:  ||:|:.:.|....:.|       .|.|.|     ..||||:: ..||..........
Worm   277 IKIQQYNDSDSELDSSVNSSPSPSLVDQREADRIADG-----ALSDSEVD-RQRDRNATPEPHDV 335

  Fly   429 ASWKWGELP-TPEQAKNEAMSAAQVQQSEHQSMLSNMFSFMKRAN-------RLRKEKGVGEVGD 485
            ..||||||| |.||.|.:.      |..:.:...|...|:..|::       :..|||...|...
Worm   336 TDWKWGELPETREQNKRKK------QDEDAEKSTSRWSSWFWRSSTSTADEEQKEKEKLEQEEQG 394

  Fly   486 IYLSDLDAGSMDPEMAALYFPSPLSKAASPPEEDGESGNGTSLPHSPSSLEEGQKSIDSDFDETK 550
            |.|.:|...|.:|.....|...|.|..:.   :.|....|.|.|.||.|..:       |:..|.
Worm   395 ISLDELLNSSSNPVEIEKYLGKPPSVTSI---DSGHVSRGVSQPSSPISNHD-------DYTPTT 449

  Fly   551 QQRDNNRYLDFVAMSMCGMSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKYYTWM 615
                                   .||:|              |:|:..|     ||...
Worm   450 -----------------------TPPND--------------KTPTRES-----VRFGA------ 466

  Fly   616 AACPIVMTMITFQKPLTHDAIEQLMSQTVDGKCLPGDEKQEAVAQADNGGQTKRYWWSWRRSQDA 680
                                          |..:|..      ..|.||.::       |.|.|.
Worm   467 ------------------------------GNDIPSS------TSATNGVRS-------RASSDE 488

  Fly   681 APNHLNNTHGMPLGKDEKDGDQAAVATQTSRPTSPDITDPTLSKSDSLVNAENTSALVDNLEELT 745
            .         .||.:||.|                                       ||.
Worm   489 I---------FPLSEDELD---------------------------------------DNF---- 501

  Fly   746 MASNKSDEPKERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVI 810
                     :.:|.:||||||..:|.|.|..|.||:.||:||.:||||.|.|.::.:|..:::|:
Worm   502 ---------RPQYMQSLRLSSEKLKSLGLVFGANELRFSITTKFQGTTWCSCNIYLYKWYEQIVV 557

  Fly   811 SDIDGTITKSDVLGHILPMVGKDWAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYLRSIR 875
            |||||||||||||||::|.:|..||..|||:|:::|:.||||::|||:||||||..|::||:|:.
Worm   558 SDIDGTITKSDVLGHVIPAIGGTWAHTGVAELYTRIKNNGYKMVYLSSRAIGQSHTTKQYLKSVA 622

  Fly   876 QGNVMLPDGPLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDLFPDKEPFYAGYGNRINDVWA 940
            |.:..|||||:||:|||:|:||.|||||::||:||||.|:|::.|||...|||||:||||.||.:
Worm   623 QDSKQLPDGPVLLSPTSIITAFRREVIERRPEEFKIAALTDLKQLFPSGNPFYAGFGNRITDVVS 687

  Fly   941 YRAVGIPIMRIFTINTKGELKHELTQTFQSSG----YINQSLE-VDEYFPLLTNQDEFDYR---- 996
            |.||.:|..||..|:..|::|..     .|||    |.:.:.: ||..||.|:...:.|.|
Worm   688 YEAVAVPAARILIIDPSGKVKRS-----DSSGLALSYKSMASDTVDYMFPPLSVHVKGDARKTER 747

  Fly   997 ---------------------TDIFDDEESEEELQ 1010
                                 .|:.|||..|.|.|
Worm   748 LTSTWSKPLEHSNFTHWHMTPKDVHDDELLEYEAQ 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436	57/101 (56%)
		Lipin_mid	562..671	CDD:293481	13/108 (12%)
		LNS2	760..985	CDD:285447	121/229 (53%)
lpin-1	NP_506380.2	SMP2	1..736	CDD:227415	302/1027 (29%)
lpin-1	NP_506380.2	LNS2	508..732	CDD:369773	121/228 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166824
Domainoid	1	1.000	254	1.000	Domainoid score	I1116
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	429	1.000	Inparanoid score	I966
Isobase	1	0.950	-	0	Normalized mean entropy	S3103
OMA	1	1.010	-	-		QHG51957
OrthoDB	1	1.010	-	-		D405645at33208
OrthoFinder	1	1.000	-	-		FOG0001100
OrthoInspector	1	1.000	-	-		oto19559
orthoMCL	1	0.900	-	-		OOG6_100990
Panther	1	1.100	-	-	LDO	PTHR12181
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R805
SonicParanoid	1	1.000	-	-		X664
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.840