Protein Alignment Pabp2 and RBM39

DIOPT Version :10

• Sequence 1: NP_476902.1
• Gene: Pabp2 / 35788
• FlyBaseID: FBgn0005648
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: NP_909122.1
• Gene: RBM39 / 9584
• HGNCID: 15923
• Length: 530
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 48/232 - (20%)
• Similarity: 85/232 - (36%)
• Gaps: 70/232 - (30%)

  Fly    46 AIKARVKEMEE---------EAEKIKQMQSEVDKQMAGGSTTGLATVPLSLE------------- 88
            |.:.|.:::||         :...|....|...|.:|......:::|||::.
Human   161 AARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIV 225

  Fly    89 -----------------EKQEIDTRSVYVGNVDYGASAEELEAHFHGCGTINRVTILCNKADGHP 136
                             :|.......:|||::.:..:.:.|...|...|.|..:.::.:...|..
Human   226 QASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRS 290

  Fly   137 KGFAYIEFGSKEFVETAL-AMNETLFRGRQIKV--MSKRTN--------------RPG--LSTTN 182
            ||:.:|.|...|..:.|| .:|.....||.:||  :::||:              |.|  |.||.
Human   291 KGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTG 355

  Fly   183 R---FARGSFRGRGARVSRACCHSTFRGARRAMGYRG 216
            |   .||.: .|.|.::..|        |::|:...|
Human   356 RLQLMARLA-EGTGLQIPPA--------AQQALQMSG 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pabp2	NP_476902.1	DNA_pol_phi	<3..68	CDD:461488	6/30 (20%)
		RRM_II_PABPN1	97..172	CDD:409966	20/77 (26%)
RBM39	NP_909122.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..146
		SF-CC1	46..518	CDD:273721	48/232 (21%)
		Interaction with JUN. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..406		28/102 (27%)
		Activating domain. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..355		18/63 (29%)
		Interaction with ESR1 and ESR2. /evidence=ECO:0000250|UniProtKB:Q8VH51	355..406		9/38 (24%)
		Interaction with NCOA6. /evidence=ECO:0000250|UniProtKB:Q8VH51	406..530