Protein Alignment Pabp2 and RNPS1

DIOPT Version :10

• Sequence 1: NP_476902.1
• Gene: Pabp2 / 35788
• FlyBaseID: FBgn0005648
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: NP_006702.1
• Gene: RNPS1 / 10921
• HGNCID: 10080
• Length: 305
• Species: Homo sapiens
• Alignment Length: 58
• Identity: 15/58 - (25%)
• Similarity: 28/58 - (48%)
• Gaps: 1/58 - (1%)

  Fly    98 VYVGNVDYGASAEELEAHFHGCGTINRVTILCNKADGH-PKGFAYIEFGSKEFVETAL 154
            |::|.:....:.:.:...|...|.|..:.:...:...| .||:||:||.:.:..|.||
Human   163 VHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKAL 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pabp2	NP_476902.1	DNA_pol_phi	<3..68	CDD:461488
		RRM_II_PABPN1	97..172	CDD:409966	15/58 (26%)
RNPS1	NP_006702.1	Necessary for interaction with the cleaved p110 isoform of CDC2L1	1..220		13/56 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..170		2/6 (33%)
		Necessary for interaction with SRP54, nuclear localization and exon-skipping. /evidence=ECO:0000269|PubMed:14729963	1..161
		Necessary for interactions with UPF2 and UPF3B and UPF2-dependent NMD	69..121
		Necessary for interaction with PNN and exon-skipping	156..242		15/58 (26%)
		Interaction with SAP18 and ACIN1. /evidence=ECO:0000269|PubMed:20966198	159..244		15/58 (26%)
		RRM_RNPS1	163..236	CDD:409800	15/58 (26%)
		Necessary for interaction with TRA2B, nuclear localization and exon-skipping. /evidence=ECO:0000269|PubMed:14729963	238..305
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..305