Protein Alignment Socs44A and SOCS5

DIOPT Version :10

• Sequence 1: NP_523659.1
• Gene: Socs44A / 35786
• FlyBaseID: FBgn0033266
• Length: 342
• Species: Drosophila melanogaster
• Sequence 2: NP_054730.1
• Gene: SOCS5 / 9655
• HGNCID: 16852
• Length: 536
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 66/278 - (23%)
• Similarity: 112/278 - (40%)
• Gaps: 78/278 - (28%)

  Fly   102 NVFARLRRKVGQGLSSLRNWHS---MGDCDDGGTTDATYEFLTPAICPEPTLPFTHDYLRFIRKK 163
            |...:|..|:..|::.:....|   ..:||.        |..|..:|           |:..|:|
Human   294 NPLYKLGPKLAPGMTEISGDSSAIPQANCDS--------EEDTTTLC-----------LQSRRQK 339

  Fly   164 WLERE---DAHS----------PNQIMYKAC-----SEMLNQVWYWGEISRRDSQRQLSDKPTGS 210
              :|:   |:|:          ..||.|..|     .::.....|||.:.|.:::..|..||.|:
Human   340 --QRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGT 402

  Fly   211 FLVRDSETSGSQFTLSFRIVNVTLHYRLEYRDNFWHFEELKYESIVEMIED--ILHRCTNDNFVC 273
            ||:|||......|::|||..|.:||.|:|..::.:.|:          ..|  :.|..|....:.
Human   403 FLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFD----------AHDPCVFHSSTVTGLLE 457

  Fly   274 FVKVPNE---MQPPFPVILK--YPLSRYSNMPKLQDLCRRVLQRQMSREQLAQLPVPAQMLEYLS 333
            ..|.|:.   .:|...:.|.  :|.|       ||.:||.|:.|..:.:.:..||:|:.:.::|.
Human   458 HYKDPSSCMFFEPLLTISLNRTFPFS-------LQYICRAVICRCTTYDGIDGLPLPSMLQDFLK 515

  Fly   334 ------------VERELV 339
                        :|||.|
Human   516 EYHYKQKVRVRWLEREPV 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	25/79 (32%)
		SOCS	293..333	CDD:470605	10/39 (26%)
SOCS5	NP_054730.1	Required for interaction with IL4R. /evidence=ECO:0000250	1..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..175
		SOCS	145..195	CDD:432667
		SH2	370..470	CDD:472789	28/109 (26%)
		SOCS_SOCS5	479..534	CDD:239708	16/62 (26%)