DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Socs44A and SOCS6

DIOPT Version :9

Sequence 1:	NP_523659.1	Gene:	Socs44A / 35786	FlyBaseID:	FBgn0033266	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_004223.2	Gene:	SOCS6 / 9306	HGNCID:	16833	Length:	535	Species:	Homo sapiens

Alignment Length:	155	Identity:	59/155 - (38%)
Similarity:	88/155 - (56%)	Gaps:	7/155 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 EMLNQVWYWGEISRRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRIVNVTLHYRLEYRDNFWHF 247
            ::..|.||||.|:|.:::.:|::.|.||||||||.......:||||....|||.|:|:.:..:.|
Human   378 KLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSF 442

  Fly   248 EELK----YESIVEMIEDILHRCTNDNFVCFVKVPNEMQPPFPVILKYPLSRYSNMPKLQDLCRR 308
            .|..    :.|||::||..:....|..| |:.:........:||.|..|:||:..:..||.|||.
Human   443 YEQPDVEGHTSIVDLIEHSIRDSENGAF-CYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRF 506

  Fly   309 VLQRQMSREQLAQ-LPVPAQMLEYL 332
            |: ||.:|..|.| ||:|.:|.:||
Human   507 VI-RQYTRIDLIQKLPLPNKMKDYL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	32/81 (40%)
Socs44A	NP_523659.1	SOCS	293..333	CDD:295349	19/41 (46%)
SOCS6	NP_004223.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..105
		SH2_SOCS6	373..472	CDD:198250	35/94 (37%)
		SOCS_SOCS6	495..535	CDD:239709	17/37 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3554
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770