Protein Alignment Socs44A and SOCS3

DIOPT Version :10

• Sequence 1: NP_523659.1
• Gene: Socs44A / 35786
• FlyBaseID: FBgn0033266
• Length: 342
• Species: Drosophila melanogaster
• Sequence 2: NP_003946.3
• Gene: SOCS3 / 9021
• HGNCID: 19391
• Length: 225
• Species: Homo sapiens
• Alignment Length: 204
• Identity: 47/204 - (23%)
• Similarity: 86/204 - (42%)
• Gaps: 43/204 - (21%)

  Fly   165 LEREDAHSPNQIMYKACSEMLNQVWYWGEISRRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRI 229
            |:...:.|..|::..|..::....:||..::..::...||.:|.|:||:|||......||||.:.
Human    22 LKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKT 86

  Fly   230 VNVTLHYRLEYRDNFWHFEE--------LKYESIVEMIEDILHRCTNDNFVCFVKVPNEM----- 281
            .:.|.:.|::.....:..:.        .:::.:::::.   |.........|...|.|.
Human    87 QSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVH---HYMPPPGAPSFPSPPTEPSSEVP 148

  Fly   282 ----------QPP------------FPVILKYPLSRYSNMPKLQDLCRRVLQRQM-SREQLAQLP 323
                      .||            .|::|..|||  ||:..||.|||:.:...: |.|::.|||
Human   149 EQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS--SNVATLQHLCRKTVNGHLDSYEKVTQLP 211

  Fly   324 VPAQMLEYL 332
            .|.:  |:|
Human   212 GPIR--EFL 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	18/85 (21%)
		SOCS	293..333	CDD:470605	17/41 (41%)
SOCS3	NP_003946.3	Kinase inhibitory region (KIR)	22..33		2/10 (20%)
		Extended SH2 subdomain (ESS)	34..45		1/10 (10%)
		SH2_SOCS3	35..135	CDD:198247	19/102 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	131..162		4/30 (13%)
		SOCS_SOCS3	184..225	CDD:239706	15/37 (41%)