Protein Alignment Socs44A and Socs3

DIOPT Version :10

• Sequence 1: NP_523659.1
• Gene: Socs44A / 35786
• FlyBaseID: FBgn0033266
• Length: 342
• Species: Drosophila melanogaster
• Sequence 2: NP_446017.2
• Gene: Socs3 / 89829
• RGDID: 621087
• Length: 225
• Species: Rattus norvegicus
• Alignment Length: 204
• Identity: 48/204 - (23%)
• Similarity: 87/204 - (42%)
• Gaps: 43/204 - (21%)

  Fly   165 LEREDAHSPNQIMYKACSEMLNQVWYWGEISRRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRI 229
            |:...:.|..|::..|..::....:||..::..::...||.:|.|:||:|||......||||.:.
  Rat    22 LKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKT 86

  Fly   230 VNVTLHYRLEYRDNFWHFEE--------LKYESIVEMIEDILHRCTNDNFVCFVKVPNE------ 280
            .:.|.:.|::.....:..:.        .:::.:::::.   |.........|...|.|
  Rat    87 QSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVH---HYMPPPGAPSFSLPPTEPSSEVQ 148

  Fly   281 MQPP---------------------FPVILKYPLSRYSNMPKLQDLCRRVLQRQM-SREQLAQLP 323
            .|||                     .|::|..|||  ||:..||.|||:.:...: |.|::.|||
  Rat   149 EQPPAQALPGGTPKRAYYIYSGGEKIPLVLSRPLS--SNVATLQHLCRKTVNGHLDSYEKVTQLP 211

  Fly   324 VPAQMLEYL 332
            .|.:  |:|
  Rat   212 GPIR--EFL 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	18/85 (21%)
		SOCS	293..333	CDD:470605	17/41 (41%)
Socs3	NP_446017.2	Kinase inhibitory region (KIR)	22..33		2/10 (20%)
		Extended SH2 subdomain (ESS)	34..45		1/10 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	141..160		4/18 (22%)