Protein Alignment Socs44A and SOCS1

DIOPT Version :10

• Sequence 1: NP_523659.1
• Gene: Socs44A / 35786
• FlyBaseID: FBgn0033266
• Length: 342
• Species: Drosophila melanogaster
• Sequence 2: NP_003736.1
• Gene: SOCS1 / 8651
• HGNCID: 19383
• Length: 211
• Species: Homo sapiens
• Alignment Length: 202
• Identity: 52/202 - (25%)
• Similarity: 85/202 - (42%)
• Gaps: 49/202 - (24%)

  Fly   142 PAICPEPTLPFTH--------DYLRFIRKKWLEREDAHSPNQIMYKACSEMLNQVWYWGEISRRD 198
            ||: |.|....||        ||.|..|.            ..:..||.      :|||.:|...
Human    43 PAV-PAPAPGDTHFRTFRSHADYRRITRA------------SALLDACG------FYWGPLSVHG 88

  Fly   199 SQRQLSDKPTGSFLVRDSETSGSQFTLSFRIVNVTLHYRLEYRDNFWHFEELK--YESIVEMIED 261
            :..:|..:|.|:||||||......|.||.::.:.....|:.::...:|.:..:  ::.:.|::|.
Human    89 AHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEH 153

  Fly   262 ILHRCTNDNFVCFVKVPNEMQPPFPVILKYPLSRYSNMPKLQDLCRRVLQRQMSREQLAQLPVPA 326
                        :|..|..|       |..|| |...:..||:|||:.:...:.||.||::|:..
Human   154 ------------YVAAPRRM-------LGAPL-RQRRVRPLQELCRQRIVATVGRENLARIPLNP 198

  Fly   327 QMLEYLS 333
            .:.:|||
Human   199 VLRDYLS 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	20/79 (25%)
		SOCS	293..333	CDD:470605	13/39 (33%)
SOCS1	NP_003736.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		4/10 (40%)
		Kinase inhibitory region (KIR)	55..66		2/10 (20%)
		Extended SH2 subdomain (ESS)	67..78		2/22 (9%)
		SH2_SOCS1	68..165	CDD:198245	27/133 (20%)
		SOCS_SOCS1	169..211	CDD:239704	13/37 (35%)
		Interaction with Elongin BC complex. /evidence=ECO:0000250	173..182		5/8 (63%)