DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Socs44A and Cish

DIOPT Version :9

Sequence 1:	NP_523659.1	Gene:	Socs44A / 35786	FlyBaseID:	FBgn0033266	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_113992.1	Gene:	Cish / 83681	RGDID:	69261	Length:	257	Species:	Rattus norvegicus

Alignment Length:	238	Identity:	63/238 - (26%)
Similarity:	97/238 - (40%)	Gaps:	51/238 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 PAICPEPTLPFTHDYLRFIRKKWLEREDAHSPNQ-----------IMYKACSEMLNQVWYWGEIS 195
            ||:.|.||..|..:.        .|.....|.|:           .:.|..|.:....||||.|:
  Rat    32 PAMQPLPTGAFPEEV--------TEETPVQSENEPKVLDPEGDLLCIAKTFSYLRESGWYWGSIT 88

  Fly   196 RRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRIVNVTLHYRLEYRDNFWHFEE--------LKY 252
            ..::::.|...|.|:||||||......||||.:......:.|:||.|:.:..:.        |.:
  Rat    89 ASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAF 153

  Fly   253 ESIVEMIEDILHRCTNDNF--------VCFVKVPNEMQPPFPVI-----------LKYPLSRYSN 298
            ..:|.:::..:..||.|..        ...:.||....|..||:           |..|..|.|:
  Rat   154 PDVVSLVQHYVASCTADTRSDSPDPAPTPALPVPKPDAPGDPVLPIPVATAVHLKLVQPFVRRSS 218

  Fly   299 MPKLQDLCRRVLQRQMSREQLAQLPVPAQMLEYLSVERELVFQ 341
            ...||.|||.|:.|.::  .:..||:|.:|.:||   |:..||
  Rat   219 ARSLQHLCRLVINRLVT--DVDCLPLPRRMADYL---RQYPFQ 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	24/85 (28%)
Socs44A	NP_523659.1	SOCS	293..333	CDD:295349	14/39 (36%)
Cish	NP_113992.1	SH2_CIS	77..164	CDD:198285	24/86 (28%)
Cish	NP_113992.1	SOCS_CIS1	217..257	CDD:239703	17/45 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336652
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740