DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Socs44A and socs5a

DIOPT Version :9

Sequence 1:	NP_523659.1	Gene:	Socs44A / 35786	FlyBaseID:	FBgn0033266	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_001107230.1	Gene:	socs5a / 768142	ZFINID:	ZDB-GENE-061013-408	Length:	528	Species:	Danio rerio

Alignment Length:	335	Identity:	77/335 - (22%)
Similarity:	125/335 - (37%)	Gaps:	100/335 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 NEVCVLEAADSSMASCSNGGTGTGTLRRRR------------DKDKRNVFA---------RLRRK 110
            |.:.:..:.|:..|:|::.......||.||            |.....|.|         :|..|
Zfish   229 NVIPLDSSPDACGATCASPEDEEERLRERRRLSIEEGVDPPPDAQIHTVEAITAPLASLYKLGPK 293

  Fly   111 VGQGLSSLRNWHSMGD--------CD--DGGTTDATYEFLTPAICPEPTLPFTHDYLRFIRKKWL 165
            :..|:.     .::||        ||  |..||         .:|.:...|          |:|.
Zfish   294 LAPGMG-----EAVGDSRGAAAANCDSEDDETT---------TLCLQARKP----------KQWQ 334

  Fly   166 EREDAHSPN----------QIMYKAC--SEMLNQV----WYWGEISRRDSQRQLSDKPTGSFLVR 214
            ...:.|..:          ||.|..|  .::| |:    .|||.:.|.:::..|..:|.|:||:|
Zfish   335 ASGEGHPSSKQPGPWKVHTQIDYIHCLVPDLL-QITALPCYWGVMDRYEAEALLDGRPEGTFLLR 398

  Fly   215 DSETSGSQFTLSFRIVNVTLHYRLEYRDNFWHFEELKYESIVEMIED--ILHRCTNDNFVCFVKV 277
            ||......|::|||....:||.|:|..::.:.|:          ..|  :.|..|....:...|.
Zfish   399 DSAQEDYLFSVSFRRYGRSLHARIEQWNHNFSFD----------AHDPCVFHAATVTALLEHYKD 453

  Fly   278 PNEMQPPFPVILKYPLSRYSNMP-KLQDLCRRVLQRQMSREQLAQLPVPAQMLEYLS-------- 333
            |:... .|..:|..||.|  ..| .||.|.|..:...::.:.:..||:|..:.:||.
Zfish   454 PSACM-FFEPLLTVPLHR--TFPFGLQSLARAAICHGITYDGIGALPLPPALQDYLREYHYKQRV 515

  Fly   334 ----VERELV 339
                :|||.|
Zfish   516 RVRWLEREPV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	23/83 (28%)
Socs44A	NP_523659.1	SOCS	293..333	CDD:295349	11/40 (28%)
socs5a	NP_001107230.1	SOCS	<160..184	CDD:289383
		SH2	362..462	CDD:301589	29/111 (26%)
		SOCS	471..526	CDD:295349	14/55 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840