DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Socs44A and Socs5

DIOPT Version :9

Sequence 1:	NP_523659.1	Gene:	Socs44A / 35786	FlyBaseID:	FBgn0033266	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_062628.2	Gene:	Socs5 / 56468	MGIID:	2385459	Length:	536	Species:	Mus musculus

Alignment Length:	482	Identity:	101/482 - (20%)
Similarity:	169/482 - (35%)	Gaps:	174/482 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QSQNQSSQRSQAL-------TGGGDSP------RDREKEKKGW----FHSLTRRKKSDSALAVTA 53
            ::||.:::..|.:       :..|.:|      ||.......|    .||.:  .|:.|:|....
Mouse    78 RNQNCAAEIPQVVEISIEKDSDSGATPGTRLARRDSYSRHAPWGGKKKHSCS--TKTQSSLDTEK 140

  Fly    54 SAAVSTSGSQNNNNEVCVLEAADSSMASCSNGGTGTGTLRRR-------------RDKDKRNVFA 105
            ....:.||.|.......|....|  |.|.|:...|:.:||:|             ..|..:.:|:
Mouse   141 KFGRTRSGLQRRERRYGVSSMQD--MDSVSSRAVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFS 203

  Fly   106 RLRRKV--------------GQGLSSLRNWH------------------------SMGDCDDG-- 130
            . :||:              |..|:  :.||                        |..|.:|.
Mouse   204 N-KRKIHLSELMLEKCPFPAGSDLA--QKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLR 265

  Fly   131 -------------------GTTDATYEF-----LTPAICPEPT--------LPFTHD-------- 155
                               .|.:||.:.     |.|.:.|..|        :|.|:.
Mouse   266 ERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDGSAIPQTNCDSEEDSTT 330

  Fly   156 -YLRFIRKKWLERE---DAHS----------PNQIMYKAC-----SEMLNQVWYWGEISRRDSQR 201
             .|:..|:|  :|:   |:|:          ..||.|..|     .::.....|||.:.|.:::.
Mouse   331 LCLQSRRQK--QRQVSGDSHAHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEA 393

  Fly   202 QLSDKPTGSFLVRDSETSGSQFTLSFRIVNVTLHYRLEYRDNFWHFEELKYESIVEMIED--ILH 264
            .|..||.|:||:|||......|::|||..|.:||.|:|..::.:.|:          ..|  :.|
Mouse   394 LLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFD----------AHDPCVFH 448

  Fly   265 RCTNDNFVCFVKVPNE---MQPPFPVILK--YPLSRYSNMPKLQDLCRRVLQRQMSREQLAQLPV 324
            ..|....:...|.|:.   .:|...:.|.  :|.|       ||.:||.|:.|..:.:.:..||:
Mouse   449 SSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFS-------LQYICRAVICRCTTYDGIDGLPL 506

  Fly   325 PAQMLEYLS------------VERELV 339
            |:.:.::|.            :|||.|
Mouse   507 PSMLQDFLKEYHYKQKVRVRWLEREPV 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	25/79 (32%)
Socs44A	NP_523659.1	SOCS	293..333	CDD:295349	10/39 (26%)
Socs5	NP_062628.2	Required for interaction with IL4R	1..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..59
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..175		19/83 (23%)
		SOCS	146..195	CDD:372221	12/50 (24%)
		SH2	370..470	CDD:387587	28/109 (26%)
		SOCS_SOCS5	479..534	CDD:239708	16/62 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.700