DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Socs44A and socs5b

DIOPT Version :9

Sequence 1:	NP_523659.1	Gene:	Socs44A / 35786	FlyBaseID:	FBgn0033266	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	XP_005156658.1	Gene:	socs5b / 559639	ZFINID:	ZDB-GENE-080722-18	Length:	598	Species:	Danio rerio

Alignment Length:	386	Identity:	85/386 - (22%)
Similarity:	130/386 - (33%)	Gaps:	116/386 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SQNQSSQRSQALTGGGDSPRDREKEKKGWFHSLTRRKKSDSALAVTASAAVSTSGSQNNNNEVCV 71
            |.:.||....|......||.|.|:..:      .||:.|           :........|.::..
Zfish   276 SPHSSSALFDAFDSAHSSPEDEEERLR------ERRRLS-----------IEEGVDPPPNAQIHT 323

  Fly    72 LEAADSSMASCSNG-------------GTGTGTLRRRRDKDKRNVFARLRRKVGQGLSSLRNW-- 121
            |||...|.:....|             |...||:                ..:..|||.:...
Zfish   324 LEATSKSSSLYKLGPKMAPGVGETLGEGRSLGTV----------------SSISGGLSGIAAQVP 372

  Fly   122 -------HSMGDCDDGGTTDATYEFLTPAICPEPTLPFTHDYLRFIRKKWLEREDAHSP------ 173
                   |:: |||  ...|:|      .:|.:...|          |:.....|.|..
Zfish   373 TSMAVPSHTV-DCD--SEEDST------TLCLQTRRP----------KQRHASGDTHCSRQPGPW 418

  Fly   174 ---NQIMYKAC-----SEMLNQVWYWGEISRRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRIV 230
               .||.|..|     ..:.....|||.:.|..::..|..:|.|:||:|||......|::|||..
Zfish   419 KVHTQIDYIHCLVPDLQAITALPCYWGVMDRYQAEALLDGRPEGTFLLRDSAQEDYLFSVSFRRY 483

  Fly   231 NVTLHYRLEYRDNFWHFEELKYESIVEMIED--ILHRCTNDNFVCFVKVPNEMQPPFPVILKYPL 293
            |.:||.|:|..::.:.|:          ..|  :.|..|....:...|.|:... .|..:|..||
Zfish   484 NRSLHARIEQWNHNFSFD----------AHDPCVFHSSTVTGLLEHYKDPSACM-FFEPLLTAPL 537

  Fly   294 SRYSNMP-KLQDLCRRVLQRQMSREQLAQLPVPAQMLEYLS------------VERELVFQ 341
            .|  ..| .||.|.|..:.|..:.:.:..||:|..|.::|.            :|||..|:
Zfish   538 HR--TFPFSLQHLARSSICRHTTYDGIGALPLPPTMQDFLKEYHYKQKVRVRWLEREPPFK 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	24/79 (30%)
Socs44A	NP_523659.1	SOCS	293..333	CDD:295349	12/40 (30%)
socs5b	XP_005156658.1	SOCS	174..228	CDD:289383
		SH2	431..531	CDD:301589	28/110 (25%)
		SOCS_SOCS5	540..596	CDD:239708	14/55 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740