DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Socs44A and Socs4

DIOPT Version :9

Sequence 1:	NP_523659.1	Gene:	Socs44A / 35786	FlyBaseID:	FBgn0033266	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_001100726.1	Gene:	Socs4 / 305828	RGDID:	1306503	Length:	436	Species:	Rattus norvegicus

Alignment Length:	346	Identity:	84/346 - (24%)
Similarity:	130/346 - (37%)	Gaps:	109/346 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ALTGGGDS----------PRDREKEKKGWFHSLTRRKKSDSALAVTASAAVSTSGSQNNNNEVCV 71
            ||:...|.          |||.:         |.||...|.....:.::.           :.||
  Rat   150 ALSSSSDEWVSTDLCERRPRDAQ---------LKRRSTEDDIPCFSHTSV-----------QPCV 194

  Fly    72 LEAADSSMASCSNGGTGTGTLRRRRDKDKRNVFARLRRKVGQGLSSLRNWHSMGDCDDGGTTDAT 136
            :   .::.|||: ||..||:                       |.:|...:||.|    |..|:.
  Rat   195 I---TTNSASCA-GGHVTGS-----------------------LMNLVTDNSMED----GDMDSE 228

  Fly   137 YEFLTPAICPEPTLPFTHDYLRFIRK----KWLEREDA----HSP----NQIMYKAC-----SEM 184
            .|.:|  :|...            ||    :| |.:|.    .:|    .||.|..|     .::
  Rat   229 DEIIT--LCTSS------------RKRNKPRW-ETDDGILQLEAPPKFHTQIDYVHCLVPDLLQI 278

  Fly   185 LNQVWYWGEISRRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRIVNVTLHYRLEYRDNFWHFEE 249
            .|...|||.:.:..::..|..||.|:||:|||......|::|||..:.:||.|:|..::.:.|:
  Rat   279 SNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFD- 342

  Fly   250 LKYESIVEMIEDI--LHRCTNDNFVCFVKVPNEMQPPFPVILKYPLSRYSNMP-KLQDLCRRVLQ 311
             .::..|....||  |.....|...|..         |..:|..||.|  ..| .||.:||.|:.
  Rat   343 -AHDPCVFHSPDITGLLEHYKDPSACMF---------FEPLLSTPLIR--TFPFSLQHICRTVIC 395

  Fly   312 RQMSREQLAQLPVPAQMLEYL 332
            ...:.:.:..||:|:.|..||
  Rat   396 NCTTYDGIDALPIPSPMKLYL 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	25/79 (32%)
Socs44A	NP_523659.1	SOCS	293..333	CDD:295349	14/41 (34%)
Socs4	NP_001100726.1	SOCS	58..105	CDD:289383
		SH2_SOCS4	272..372	CDD:198248	29/110 (26%)
		SOCS	381..436	CDD:295349	12/36 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.700