Protein Alignment Socs44A and Socs3

DIOPT Version :10

• Sequence 1: NP_523659.1
• Gene: Socs44A / 35786
• FlyBaseID: FBgn0033266
• Length: 342
• Species: Drosophila melanogaster
• Sequence 2: NP_031733.1
• Gene: Socs3 / 12702
• MGIID: 1201791
• Length: 225
• Species: Mus musculus
• Alignment Length: 204
• Identity: 48/204 - (23%)
• Similarity: 87/204 - (42%)
• Gaps: 43/204 - (21%)

  Fly   165 LEREDAHSPNQIMYKACSEMLNQVWYWGEISRRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRI 229
            |:...:.|..|::..|..::....:||..::..::...||.:|.|:||:|||......||||.:.
Mouse    22 LKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKT 86

  Fly   230 VNVTLHYRLEYRDNFWHFEE--------LKYESIVEMIEDILHRCTNDNFVCFVKVPNE------ 280
            .:.|.:.|::.....:..:.        .:::.:::::.   |.........|...|.|
Mouse    87 QSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVH---HYMPPPGTPSFSLPPTEPSSEVP 148

  Fly   281 MQPP---------------------FPVILKYPLSRYSNMPKLQDLCRRVLQRQM-SREQLAQLP 323
            .|||                     .|::|..|||  ||:..||.|||:.:...: |.|::.|||
Mouse   149 EQPPAQALPGSTPKRAYYIYSGGEKIPLVLSRPLS--SNVATLQHLCRKTVNGHLDSYEKVTQLP 211

  Fly   324 VPAQMLEYL 332
            .|.:  |:|
Mouse   212 GPIR--EFL 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	18/85 (21%)
		SOCS	293..333	CDD:470605	17/41 (41%)
Socs3	NP_031733.1	Kinase inhibitory region (KIR)	22..33		2/10 (20%)
		Extended SH2 subdomain (ESS)	34..45		1/10 (10%)
		SH2_SOCS3	35..135	CDD:198247	19/102 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	131..160		6/28 (21%)
		SOCS_SOCS3	184..225	CDD:239706	15/37 (41%)