DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Socs44A and SOCS4

DIOPT Version :9

Sequence 1:	NP_523659.1	Gene:	Socs44A / 35786	FlyBaseID:	FBgn0033266	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_543143.1	Gene:	SOCS4 / 122809	HGNCID:	19392	Length:	440	Species:	Homo sapiens

Alignment Length:	275	Identity:	74/275 - (26%)
Similarity:	112/275 - (40%)	Gaps:	61/275 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 GTLRRRRDKDKRNVFAR-------------LRRKVGQGLSSLRNWHSMGDCDDGGTTDATYEFLT 141
            |.|:||..::..|.|:.             |.|: |....|:.|..|....:| ...|:..|.||
Human   174 GQLKRRNMEENINCFSHTNVQPCVITTDNALCRE-GPMTGSVMNLVSNNSIED-SDMDSDDEILT 236

  Fly   142 PAICPEPTLPFTHDYLRFIRK----KW-LERE--DAHSP----NQIMYKAC-----SEMLNQVWY 190
              :|...            ||    || |:.|  ...:|    .||.|..|     .::.|...|
Human   237 --LCTSS------------RKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCY 287

  Fly   191 WGEISRRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRIVNVTLHYRLEYRDNFWHFEELKYESI 255
            ||.:.:..::..|..||.|:||:|||......|::|||..:.:||.|:|..::.:.|:  .::..
Human   288 WGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFD--AHDPC 350

  Fly   256 VEMIEDI--LHRCTNDNFVCFVKVPNEMQPPFPVILKYPLSRYSNMP-KLQDLCRRVLQRQMSRE 317
            |....||  |.....|...|..         |..:|..||.|  ..| .||.:||.|:....:.:
Human   351 VFHSPDITGLLEHYKDPSACMF---------FEPLLSTPLIR--TFPFSLQHICRTVICNCTTYD 404

  Fly   318 QLAQLPVPAQMLEYL 332
            .:..||:|:.|..||
Human   405 GIDALPIPSSMKLYL 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	25/79 (32%)
Socs44A	NP_523659.1	SOCS	293..333	CDD:295349	14/41 (34%)
SOCS4	NP_543143.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		SOCS	59..111	CDD:315310
		SH2_SOCS4	275..375	CDD:198248	29/110 (26%)
		SOCS_SOCS4	384..439	CDD:239707	12/36 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700