DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Socs44A and CISH

DIOPT Version :9

Sequence 1:	NP_523659.1	Gene:	Socs44A / 35786	FlyBaseID:	FBgn0033266	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_037456.5	Gene:	CISH / 1154	HGNCID:	1984	Length:	275	Species:	Homo sapiens

Alignment Length:	191	Identity:	53/191 - (27%)
Similarity:	84/191 - (43%)	Gaps:	33/191 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 KACSEMLNQVWYWGEISRRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRIVNVTLHYRLEYRDN 243
            |..|.:....||||.|:..::::.|...|.|:||||||......||||.:......:.|:||.|:
Human    89 KTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADS 153

  Fly   244 FWHFEE--------LKYESIVEMIEDILHRCTNDNF--------VCFVKVPNEMQPPFPVI---- 288
            .:..:.        |.:..:|.:::..:..||.|..        ...:.:|.|..|..|.:
Human   154 SFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAPP 218

  Fly   289 --------LKYPLSRYSNMPKLQDLCRRVLQRQMSREQLAQLPVPAQMLEYLSVERELVFQ 341
                    |..|..|.|:...||.|||.|:.|.::  .:..||:|.:|.:||   |:..||
Human   219 PATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVA--DVDCLPLPRRMADYL---RQYPFQ 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs44A	NP_523659.1	SH2_SOCS_family	188..266	CDD:198178	24/85 (28%)
Socs44A	NP_523659.1	SOCS	293..333	CDD:295349	14/39 (36%)
CISH	NP_037456.5	SH2_CIS	94..181	CDD:198285	24/86 (28%)
CISH	NP_037456.5	SOCS_CIS1	235..275	CDD:239703	17/45 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142952
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	66	1.000	Inparanoid score	I5357
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.790