DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup50 and nup50

DIOPT Version :9

Sequence 1:	NP_610355.1	Gene:	Nup50 / 35784	FlyBaseID:	FBgn0033264	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001016628.1	Gene:	nup50 / 549382	XenbaseID:	XB-GENE-970394	Length:	449	Species:	Xenopus tropicalis

Alignment Length:	584	Identity:	190/584 - (32%)
Similarity:	271/584 - (46%)	Gaps:	169/584 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KRQATSNLNHENWDLEEEPEERGTFRTATEEELKTRVIKKARRKIAGGSSAAEEDGAEEKTAEPK 68
            ||.|...|...|||.|||.|:.|||..|::|.:|||.||||:|:..|  |..|..||
Frog     3 KRIADKELTDRNWDQEEEAEDAGTFSVASQEVMKTREIKKAKRRNLG--SDGESGGA-------- 57

  Fly    69 SVFSGFSGF--GKPAASPAAGS-----PFSFLANVTAPATTS-------SSEPKKSAFSFGFSSS 119
              |.||.|.  |..|:.|:.|:     |...|:|.|:.::||       :|| .|..|...|:|.
Frog    58 --FKGFKGLFSGTGASLPSFGNGSSAKPLEGLSNGTSASSTSLFINLKPASE-SKPTFGSAFTSR 119

  Fly   120 S--SSADRPVSTSICGTASTSSTAPSPLPAKESTSTVDGAKPTTSIFGNISAAKKESSEAKTSSS 182
            .  .:||:|:     |||||                                    :.|...|:|
Frog   120 PLLGAADKPL-----GTAST------------------------------------NGERALSTS 143

  Fly   183 STSLTSTMETSEYRESVADLNRSVIKFLQDQMGKSPYCILTPVFKNYDEHLKDLQDEESARTNST 247
            ..:| |....|||.:.:..||.||..::...:..:|.|.|:|:|::|::||..::.:..|.::|
Frog   144 GAAL-SKAGNSEYNKHLTSLNCSVRDWIVKHVNTNPLCDLSPIFRDYEKHLSAIEQKYGASSDS- 206

  Fly   248 KSKTAQARSQEPVAKVSRASSPPKAATTFTFG-KPSAPIGASV-SPLAKKPNCTITSGGTTTTTA 310
            .|::..|...:.:..:....:.|.|  ||:|| |..|| |..| :|...||.           .|
Frog   207 GSESDGAAQTKTIPTLHSIKADPIA--TFSFGSKDKAP-GVPVKTPPDSKPQ-----------AA 257

  Fly   311 TPLVSFGSTASFTAPVPSSSSIFSLTAKPTGEAKSDDTPKSSIF--SFGAKDTTTKKDEPNFSAP 373
            .|..:||...        .||..||.......:.|..|..||:|  |.|:..:::::.||:
Frog   258 APTFNFGQKV--------DSSTLSLIGSGGAPSFSFSTGASSLFGKSTGSTASSSQESEPS---- 310

  Fly   374 KTNGFSFGLKSNNDDKPSTSLFAGFGKAPGGAGDGAKGFSFTNSATPFSLGNIHPPAAAAAPAEE 438
                      ||.:                |.|||
Frog   311 ----------SNTE----------------GKGDG------------------------------ 319

  Fly   439 EKEEDTPPKVEFKQVVEDDAIYSKRCKVFIKKDKDFGDRGVGTLYLKPVKDSEKIQLLVRADTNL 503
             :||:.|||...::|.||||.|||:||.|.|||.:|.::|||||:|||| :::|.||||||||||
Frog   320 -EEEEEPPKAVIQEVKEDDAFYSKKCKFFYKKDNEFKEKGVGTLHLKPV-ENKKTQLLVRADTNL 382

  Fly   504 GNILVNLILSKGIPCQRMGKNNVLMVCVPTPE-DSK----ATSLLLRVKTGDEADD----LLEK 558
            ||||:|:::...:||.|.|||||::||||.|. |.|    ..:||:||||.::||:    ||||
Frog   383 GNILLNILVQPSMPCSRTGKNNVMVVCVPNPPIDEKNPTVPATLLIRVKTAEDADELHKILLEK 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup50	NP_610355.1	NUP50	4..80	CDD:312461	34/77 (44%)
Nup50	NP_610355.1	RanBD_NUP50	453..563	CDD:269991	67/115 (58%)
nup50	NP_001016628.1	NUP50	3..64	CDD:286055	32/72 (44%)
nup50	NP_001016628.1	RanBD_NUP50	332..447	CDD:269991	67/116 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10998
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4317
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D344442at33208
OrthoFinder	1	1.000	-	-		FOG0005423
OrthoInspector	1	1.000	-	-		oto105157
Panther	1	1.100	-	-	LDO	PTHR23138
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4358
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160