DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup50 and Nup358

DIOPT Version :9

Sequence 1:	NP_610355.1	Gene:	Nup50 / 35784	FlyBaseID:	FBgn0033264	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001247302.1	Gene:	Nup358 / 43041	FlyBaseID:	FBgn0039302	Length:	2718	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	162/738 - (21%)
Similarity:	262/738 - (35%)	Gaps:	225/738 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EERGTFRTATEEELKTRVIKKARRKIAGGSSAA----------------------EEDGAEEKTA 65
            |.|..|..|:|.......:|........||:|.                      :|....:...
  Fly  1431 EFRVAFTKASEAAKSKETVKPTVNTAEKGSTATAPAAFKSFVTSTPAANSLINKPQEQTKTQPNP 1495

  Fly    66 EP-----KSVFSGFSGFGKPAAS-PAAGSP---FSFLANVTAPATTSSSEPKKSAFSFGFSSSSS 121
            :|     ||:|...|....||.| ||:.:|   |||..|.::...||::.|..: .|||.:|:..
  Fly  1496 DPPATAAKSLFGTLSVSAAPATSAPASATPFASFSFTPNGSSGFGTSTASPFGN-LSFGTASAVG 1559

  Fly   122 SADRPVSTSICGTASTSSTA--------PSPLPAKESTSTVDGAKPTTSIFGNIS-------AAK 171
            |.:   :|::..||......        .|.|....|:...:...||......|:       ...
  Fly  1560 SGN---NTTLFTTALIKDNTVQGKTLQQESQLNKSNSSDAEEEYVPTAQFVPVIALPDIVEVVTG 1621

  Fly   172 KESSEAKTSSSSTSLTSTMETSEYRE----------SVADLNRSVIKFLQDQMGKSPYCI---LT 223
            :|:.:......:..|....|.:|::|          ...|.|:..:...::|:.|  .|.   |.
  Fly  1622 EENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQVHK--LCCNQRLL 1684

  Fly   224 PVFK-NYDEHLK--------DLQDEESARTNSTKSKTAQARSQ-------EPVAKVSRA--SSPP 270
            |..| .|..:.|        |..|||.    :|.....:.:||       |.|.|..::  :.|.
  Fly  1685 PETKFTYATNCKAAVTWGAQDYSDEEL----TTALLAVRFKSQDICQQFLEAVQKAQQSIGNEPK 1745

  Fly   271 KAATTFTFGKPSAPI---GASVSPLAKKPNC--TITSGG-----------TTTTTATPLVS---F 316
            |.......|:...||   |.:..|.|...||  ..|:.|           ....|..|..|   .
  Fly  1746 KEEVPSAAGEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPPKQSGLDQ 1810

  Fly   317 GSTASFTAPVPSSSSIFSLTAKPTGEAKSDDTPKSSIFSFGAKDTTTKKDEP-------NFSAP- 373
            |:..:.|.   |||:.||.     |.|.|...|.:..||||.  .|..|::|       :.|||
  Fly  1811 GNALNLTT---SSSNKFSF-----GFASSATLPATGGFSFGG--ATQPKEKPAVAVVTASASAPT 1865

  Fly   374 -------------KTNGFSFGLK---------------------------SNND----------- 387
                         .|:||....|                           ..||
  Fly  1866 SVQTAALGFGKSSMTSGFGDAFKPAVGSWSCSACYVNNPGESLYCSACDAPKNDTVPQKEKSLGS 1930

  Fly   388 --DKPSTSLFA-GFGKAPGG----AGDGAKGFSFT-------------NSATPFSLGNIHP---- 428
              :.|.||.|: |||.|..|    |||||. |:|.             :|:..||:....|
  Fly  1931 GLNLPPTSKFSFGFGAAAAGDKDQAGDGAT-FNFAAMPAAVAPTTSIGSSSFTFSMTKPKPDQQQ 1994

  Fly   429 PAAAAAPAE--------EEKEEDT--------PPKVEFKQVVED-DAIYSKRCKVFIKKDKDFGD 476
            |.:.||..:        ||:|.:|        |.|::.|...|| :.:|..:.|::...:.|:.:
  Fly  1995 PNSTAAKEDEDNDSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYRLNESDWKE 2059

  Fly   477 RGVGTLYLKPVKDSEKIQLLVRADTNLGNILVNLILSKGIPCQRMGKNNVLMVCVPTPEDSKATS 541
            ||:|.:.:...:.::|:::::|.: .:..|.:|.:|::.:..:...:.:.:..   ..:.|:..|
  Fly  2060 RGLGDVKILRHRQTKKLRVVMRRE-QVFKICLNHVLNENVVYREKTETSWMFA---VHDFSEGES 2120

  Fly   542 LL----LRVKTGDEADDLLEKIK 560
            :|    ||.|..:.|...:|.||
  Fly  2121 VLERFTLRFKNKEVAQGFMEAIK 2143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup50	NP_610355.1	NUP50	4..80	CDD:312461	15/83 (18%)
Nup50	NP_610355.1	RanBD_NUP50	453..563	CDD:269991	23/113 (20%)
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533
		TPR repeat	58..90	CDD:276809
		Atrophin-1	<1030..1308	CDD:331285
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992	4/10 (40%)
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993	25/122 (20%)
		RanBP2-type Zn finger	1774..1793	CDD:275376	4/18 (22%)
		Nucleoporin_FG2	1806..>1986	CDD:330420	47/190 (25%)
		RanBP2-type Zn finger	1833..1861	CDD:275375	8/29 (28%)
		zf-RanBP	1891..1917	CDD:279035	0/25 (0%)
		RanBP2-type Zn finger	1894..1913	CDD:275376	0/18 (0%)
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994	23/114 (20%)
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23138
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100