DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup50 and nup61

DIOPT Version :9

Sequence 1:	NP_610355.1	Gene:	Nup50 / 35784	FlyBaseID:	FBgn0033264	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_587937.2	Gene:	nup61 / 2539348	PomBaseID:	SPCC18B5.07c	Length:	549	Species:	Schizosaccharomyces pombe

Alignment Length:	555	Identity:	133/555 - (23%)
Similarity:	207/555 - (37%)	Gaps:	144/555 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 SSADR--PVSTSICGTASTSST--APSPLPAKESTSTVDGAKPTTSIFGNISAAKKESSEAKTSS 181
            |..||  ||......:|...:|  ...|...|..||.|.    :..||.|: |||..|..|.|:.
pombe    17 SDDDRHGPVEVPKEASADVMATRKIAKPKSRKRPTSGVS----SPGIFANL-AAKPVSLPASTTQ 76

  Fly   182 ---SSTSLTSTMETSEYRESVADLNRSVIKFLQDQMGKSPYCILTPVFKNYDEHLKDLQD---EE 240
               ...::|:..: |:.......||:|.|..:...:..:|:..|:|:|..|.:|...::.   ||
pombe    77 FTFGKPAVTANND-SDIHLKKRGLNKSFIDAVIKSVDNNPFGNLSPLFDEYRQHFSSIEKKPAEE 140

  Fly   241 SARTNSTKSKT--AQARSQEPVAKVSR--ASSP---------PKAATTFTFGKPSAPIGASVSPL 292
            ...:|:..|:.  .|.:||:..:.|:.  |||.         |..|..|.|..|:  :|:|..
pombe   141 QPTSNAVVSEVNPQQQKSQDSSSFVTEKPASSEKEDKEKPLVPPGAPRFGFSAPA--LGSSFQ-- 201

  Fly   293 AKKPNCTITSGGTTTTTATPLVSFG-----------------STASFTAPVPSSSSIFSLTAKPT 340
                        ..::..||..|||                 .||:.||...::...|:..|.|.
pombe   202 ------------FNSSAFTPKGSFGEKSATEAEAKEKETSSNQTATGTAATTTNQFSFNTAANPF 254

  Fly   341 GEAKSDD---TPKSSIFSFG-----------------AKDTTTKKDEP-------NFSAP-KTNG 377
            ..||.::   .|.:.:|||.                 .||:.:::.:|       |...| |.|.
pombe   255 AFAKKENEESKPLTPVFSFSTTMASADASKETKQTHETKDSKSEESKPSNNEKSENAVEPAKGNT 319

  Fly   378 FSFGLKSNNDDKP-----------------STSLFAGFGKAPGGAGDGAKGFSFTNSATPFSLG- 424
            .||   |...|||                 |..|.|.....|..|  .|.||||..:..|||..
pombe   320 MSF---SWTPDKPIKFDTPEKKFTFTNPLSSKKLPASSDVKPPSA--AAVGFSFGTTTNPFSFAA 379

  Fly   425 ------NIHPPAAAAAPAEEEKEEDTPPKVEFKQVVED-------------------DAIYSKRC 464
                  ....||:..|...||.......:.|.|:...|                   |:::..|.
pombe   380 PKSSFPTSSTPASVGAEKSEETSNGNKSEQEEKENGNDETRSNDSLVSGKGKGEENEDSVFETRA 444

  Fly   465 KV--FIKKDKDFGDRGVGTLYLKPVKDSEKIQLLVRADTNLGNILVNLILSKGIPCQRMGKNNVL 527
            |:  |....|.:.|.|:|.|.:...:|:...::|.|.:.: |.:|:|:.|.:.......||.:|.
pombe   445 KIYRFDATSKSYSDIGIGPLKINVDRDTGSARILARVEGS-GKLLLNVRLCQDFEYSLAGKKDVK 508

  Fly   528 MVCVPTPEDSKATSL-LLRVKTGDEADDLLEKIKE 561
            :....|  |.|:..: |:|||....|:.||.::.|
pombe   509 VPAAST--DGKSIEMYLIRVKEPSTAEKLLAELNE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup50	NP_610355.1	NUP50	4..80	CDD:312461
Nup50	NP_610355.1	RanBD_NUP50	453..563	CDD:269991	31/131 (24%)
nup61	NP_587937.2	NUP50	3..63	CDD:286055	14/49 (29%)
nup61	NP_587937.2	RanBD_NUP50	431..543	CDD:269991	30/114 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23138
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100