DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nup50 and NUP50

DIOPT Version :9

Sequence 1:NP_610355.1 Gene:Nup50 / 35784 FlyBaseID:FBgn0033264 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_009103.2 Gene:NUP50 / 10762 HGNCID:8065 Length:468 Species:Homo sapiens


Alignment Length:571 Identity:189/571 - (33%)
Similarity:274/571 - (47%) Gaps:124/571 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 KRQATSNLNHENWDLEEEPEERGTFRTATEEELKTRVIKKARRKIAGGSSAAEEDGAEEKTAEPK 68
            ||.|...|...|||.|:|.||.|||..|:||.||.|.||||:|:..|..|   :.|...|..:..
Human     3 KRNAEKELTDRNWDQEDEAEEVGTFSMASEEVLKNRAIKKAKRRNVGFES---DTGGAFKGFKGL 64

  Fly    69 SVFSG---FSGFGKPAASPAAGSPFSFLANVTAPATTSSSEPKKSAFSFGFSSSSSSADRPVSTS 130
            .|.||   |||||    |.|.|.|...|:|    ....:|.|.       |:|:.::||..|   
Human    65 VVPSGGGRFSGFG----SGAGGKPLEGLSN----GNNITSAPP-------FASAKAAADPKV--- 111

  Fly   131 ICGTASTSSTAPSPLPAKESTSTVDGAKPTTSIFGNISAAKKESSEAKTSSSSTSLTSTMETSEY 195
                      |...|.|...|:.||          .:|..|......:.|||..:.:.....:.|
Human   112 ----------AFGSLAANGPTTLVD----------KVSNPKTNGDSQQPSSSGLASSKACVGNAY 156

  Fly   196 RESVADLNRSVIKFLQDQMGKSPYCILTPVFKNYDEHLKDLQDE--ESARTNSTKSKTAQARSQE 258
            .:.:|.||.||..::...:..:|.|.|||:||:|:::|.:::.:  .|.|.:.::|....|.:|.
Human   157 HKQLAALNCSVRDWIVKHVNTNPLCDLTPIFKDYEKYLANIEQQHGNSGRNSESESNKVAAETQS 221

  Fly   259 PVAKVSRASSPPKAATTFTF-GKPSAPIGASVSPLAKKPNCTITSGGTTTTTATPLVSFGSTASF 322
            |..   ..|:..:..:||.| |..:.........:|.:.....:|.|.|:.:    .:||...  
Human   222 PSL---FGSTKLQQESTFLFHGNKTEDTPDKKMEVASEKKTDPSSLGATSAS----FNFGKKV-- 277

  Fly   323 TAPVPSSSSIFSLTAKP-TGEAKSDDTPKSSIFSFGAKDTTTKKDEPNFSAPKTNGFSFGLKSNN 386
                 .||.:.||::.| ||.:.|..  .||:|   .||||..|       |.::.|        
Human   278 -----DSSVLGSLSSVPLTGFSFSPG--NSSLF---GKDTTQSK-------PVSSPF-------- 317

  Fly   387 DDKPSTSLFAGFGKAPGGAGDGAKGFSFTNSATPFSLGNIHPPAAAAAPAEEEKEEDTPPKVEFK 451
               |:..|   .|:|.|.:|:...|                          :|:|.|.||||...
Human   318 ---PTKPL---EGQAEGDSGECKGG--------------------------DEEENDEPPKVVVT 350

  Fly   452 QVVEDDAIYSKRCKVFIKKDKDFGDRGVGTLYLKPVKDSEKIQLLVRADTNLGNILVNLILSKGI 516
            :|.|:||.|||:||:|.|||.:|.::|:|||:|||.. ::|.||||||||||||||:|:::...:
Human   351 EVKEEDAFYSKKCKLFYKKDNEFKEKGIGTLHLKPTA-NQKTQLLVRADTNLGNILLNVLIPPNM 414

  Fly   517 PCQRMGKNNVLMVCVPTP--EDSKAT---SLLLRVKTGDEADD----LLEK 558
            ||.|.||||||:||||.|  ::..||   ::|:||||.::||:    ||||
Human   415 PCTRTGKNNVLIVCVPNPPIDEKNATMPVTMLIRVKTSEDADELHKILLEK 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup50NP_610355.1 NUP50 4..80 CDD:312461 37/78 (47%)
RanBD_NUP50 453..563 CDD:269991 64/115 (56%)
NUP50NP_009103.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 11/22 (50%)
NUP50 3..64 CDD:401019 29/63 (46%)
5 X 2 AA repeats of F-G 76..304 69/284 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 122..148 8/35 (23%)
Binding to CDKN1B. /evidence=ECO:0000250 144..206 16/61 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..224 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 238..269 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 304..345 17/87 (20%)
RanBD_NUP50 350..466 CDD:269991 64/117 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147756
Domainoid 1 1.000 124 1.000 Domainoid score I5558
eggNOG 1 0.900 - - E1_KOG2724
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 215 1.000 Inparanoid score I3626
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48321
OrthoDB 1 1.010 - - D344442at33208
OrthoFinder 1 1.000 - - FOG0005423
OrthoInspector 1 1.000 - - oto91387
orthoMCL 1 0.900 - - OOG6_108100
Panther 1 1.100 - - LDO PTHR23138
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4031
SonicParanoid 1 1.000 - - X4358
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

Return to query results.
Submit another query.