DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asap and Smap1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001344324.1	Gene:	Smap1 / 98366	MGIID:	2138261	Length:	467	Species:	Mus musculus

Alignment Length:	625	Identity:	132/625 - (21%)
Similarity:	210/625 - (33%)	Gaps:	225/625 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 NCKEKALTKAFQHANPQMSPSLVELQKTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQ 465
            :|:|||     |..|.|....|.:|.:.        ..|..|.||.::.. .|.|.|.|:.:||:
Mouse     5 SCREKA-----QKLNEQHQLILSKLLRE--------EDNKYCADCEAKGP-RWASWNIGVFICIR 55

  Fly   466 CSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLGRGKLQHESSMEERYDFI 530
            |:|:||:||||.||::|:.||..|...:...:.|||:....:.||.|.....:.::.....: ||
Mouse    56 CAGIHRNLGVHISRVKSVNLDQWTPEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEF-FI 119

  Fly   531 RAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVL 595
            |.||..|:|.     |.|.:      |:.|                   :.||||
Mouse   120 RDKYEKKKYY-----DKNAI------AITN-------------------ISSSDA---------- 144

  Fly   596 REMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYEL 660
                             |.:.|  .::|:             |.|..|:.:..|       :.|.
Mouse   145 -----------------PLQPL--VSSPS-------------LQAAVDKNKLEK-------EKEK 170

  Fly   661 KNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGSTDFSDDETVIDERKS 725
            |..:.|              ||      |..:.....:.|: .||.:        :|..::.:||
Mouse   171 KKDEKK--------------RE------KEPEKPAKPLTTE-KLPKK--------EEQQLEPKKS 206

  Fly   726 RSRPPSFA-----------GGDSPVLRSRSSTCDSIQ----------SSSSPIANCPSRQFTLPS 769
            .| |.:.|           ..::||.....:|..::.          |:..|.|..|..|.|...
Mouse   207 TS-PKNAAEPTIDLLGLDGPAEAPVTNGNPATAPALSDDLDIFGPMISNPLPAAVMPPAQGTASV 270

  Fly   770 GLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQSDLGGH 834
            ..|: |.|..||....:...|                       :::|...|:..|:..|.|..:
Mouse   271 PAPA-TLSTVTSGDLDLFTEQ-----------------------TTKSEEVAKKQLSKDSILSLY 311

  Fly   835 VTGARKSTSTANMN------SLKKRTA---------PAP-PPGTLGSASSSSFYGTLPHPPRHSQ 883
            .|||::||....|.      :.:..||         |.| .||.:|:....: .|.:...|.|:.
Mouse   312 GTGAQQSTPGVFMGPTNIPFTSQAPTAFQGFPSMGVPVPAAPGLIGNMMGQN-TGMMVGMPMHNG 375

  Fly   884 NFDASDIRAINHKNQSLDVAYGTLPHLRSVESSPRGG---------GGYGYGVSQDPG------- 932
            ...              :...|.:|..::| ..|:||         ..:|...:|.|.
Mouse   376 FMG--------------NAQTGVMPLPQNV-VGPQGGMVGQMGAPQSKFGLPQAQQPQWNLSQMN 425

  Fly   933 --------GSGNGSNNSLMPAMTTFGHKRSPSGESLNRNI 964
                    .|.|.|.....|..||.|...|.||::|:..:
Mouse   426 QQMAAMNLSSANASAGFGQPPSTTAGWSGSSSGQTLSTQL 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071	4/8 (50%)
		ArfGap_ASAP	425..541	CDD:350063	38/115 (33%)
		Ank_2	554..662	CDD:403870	14/107 (13%)
		ANK repeat	586..622	CDD:293786	2/35 (6%)
		ANK repeat	624..662	CDD:293786	5/37 (14%)
		Ank_2	636..>693	CDD:403870	10/56 (18%)
		SH3_ASAP	1095..1149	CDD:212755
Smap1	NP_001344324.1	ArfGap	20..120	CDD:307528	33/109 (30%)
Smap1	NP_001344324.1	Med15	<343..>451	CDD:312941	23/123 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900