DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and GIT2

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_476510.1	Gene:	GIT2 / 9815	HGNCID:	4273	Length:	759	Species:	Homo sapiens

Alignment Length:	750	Identity:	160/750 - (21%)
Similarity:	257/750 - (34%)	Gaps:	213/750 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 LPGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMG 500
            |..::.|.|| |..|.:|.|:|.|..:|.:|..|||.||.|.|:::.|.........|.:...:.
Human     5 LRSSEVCADC-SGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLY 68

  Fly   501 NSTLNDIMEAKL--------GRGKLQHESSME-ERYDFIRAKYVAKRYVMR-TCSDDNDLRCDLE 555
            |:..|.|.|..|        ||.|...:..:. .:.:||||||....:|.| .|.||:
Human    69 NNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDD------- 126

  Fly   556 QAVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKA 620
             :|...|:|:.|.......:|          ||.|.|..|....:..|         |.||
Human   127 -SVTAKDLSKQLHSSVRTGNL----------ETCLRLLSLGAQANFFH---------PEKG---- 167

  Fly   621 TNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRE-LI 684
                        ||.||:.:...:....:||...|||...::|..||.:|.|::.||:...| |:
Human   168 ------------NTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLV 220

  Fly   685 ECAIK-REKSAF-------DHIN-TDWNLPN-EDGSTDFSD------------------------ 715
            |...: .::.||       ||.| ..:.:|. .|.|.|.|:
Human   221 EIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDV 285

  Fly   716 -DETVIDERKSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSPIANCPSRQFTLPSGLPSY--THS 777
             ||  :|.|::          |:..|.:::.:....:::..|.         ||.. |.|  |.:
Human   286 YDE--VDRRET----------DAVWLATQNHSALVTETTVVPF---------LPVN-PEYSSTRN 328

  Fly   778 AGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAARNSLNMQSDLGGHVTGARKST 842
            .|.......:..::.....::..:.......|..|.|..:|.....::|
Human   329 QGRQKLARFNAHEFATLVIDILSDAKRRQQGSSLSGSKDNVELILKTIN---------------- 377

  Fly   843 STANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPRH-SQNFDASD----------------- 889
               |.:|::.:....|...::.|...:....|.....|. |.:.|.||
Human   378 ---NQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDLSDGPVTVQEFMEVKNALVA 439

  Fly   890 --------IRAINHKNQSLDVAYGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNNSLMPAM 946
                    ::..|:.:..|.:....|..|:|..|:.|..........|......:.||:|.:
Human   440 SEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSL--- 501

  Fly   947 TTFGHKRSPSGESLNRNIHL----AGAKLVLPPTGEL-----------PTLKHVDKSALTRPKIP 996
                 ||.||... :|.:.:    :|.|..| |.||.           |...|:.:|||......
Human   502 -----KRRPSARG-SRPMSMYETGSGQKPYL-PMGEASRPEESRMRLQPFPAHIGRSALVTSSSS 559

  Fly   997 PPGPPSEREISNGQSNESISSMDEGPVAPPRKLVNQSANFPDYESWHTDMDSSGGG--------- 1052
            .|..||....|..:|....|.:::....|.          .||::...||:..|.|
Human   560 LPSFPSTLSWSRDESARRASRLEKQNSTPE----------SDYDNTPNDMEPDGMGSSRKGRQRS 614

  Fly  1053 --------LDHSAESNVSSSDNDRLNSSPDNPSKT 1079
                    :..:||.:|:.|..  |.|:.|...||
Human   615 MVWPGDGLVPDTAEPHVAPSPT--LPSTEDVIRKT 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	35/113 (31%)
		Ank_2	554..662	CDD:403870	23/107 (21%)
		ANK repeat	586..622	CDD:293786	9/35 (26%)
		ANK repeat	624..662	CDD:293786	9/37 (24%)
		Ank_2	636..>693	CDD:403870	17/58 (29%)
		SH3_ASAP	1095..1149	CDD:212755
GIT2	NP_476510.1	ArfGap	2..124	CDD:214518	38/119 (32%)
		ANK	109..220	CDD:238125	39/153 (25%)
		ANK 1	132..161		9/38 (24%)
		Ank_2	137..229	CDD:289560	30/126 (24%)
		ANK repeat	137..165	CDD:293786	8/46 (17%)
		ANK 2	166..195		11/44 (25%)
		ANK repeat	167..197	CDD:293786	10/45 (22%)
		ANK 3	199..228		9/28 (32%)
		GIT_SHD	266..294	CDD:285690	4/29 (14%)
		GIT_SHD	330..358	CDD:285690	1/27 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..422		7/42 (17%)
		GIT_CC	414..478	CDD:293167	11/63 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..538		15/67 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	554..643		19/100 (19%)
		GIT1_C	638..752	CDD:289013	3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810