DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and ACAP1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_055531.1	Gene:	ACAP1 / 9744	HGNCID:	16467	Length:	740	Species:	Homo sapiens

Alignment Length:	808	Identity:	193/808 - (23%)
Similarity:	310/808 - (38%)	Gaps:	201/808 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IGVLEERLEFDREGLTKLKKAVKAIHNSGNTHV-DNEMFMVRA--LERLGGKVIEQDEPDIGAAF 99
            :..||.|||       ||.|....:..||..:: .:..|:|..  |.|||     ..||.:....
Human    28 VSELETRLE-------KLLKLGTGLLESGRHYLAASRAFVVGICDLARLG-----PPEPMMAECL 80

  Fly   100 LKFSVVTKE--------LSALMKTLMQNINNIVMFPVDSMLKSELRGVKGDMKRPFDKAAKDYEA 156
            .||:|....        |.|...||.|.|..:|        |..|||.: :.:|.|.:.|:..||
Human    81 EKFTVSLNHKLDSHAELLDATQHTLQQQIQTLV--------KEGLRGFR-EARRDFWRGAESLEA 136

  Fly   157 KF---IKIEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQLQTCEYLLKYKDIKTKTGIELL 218
            ..   .::.:.:..:|:|||..            :...|..|:.:..:|.|:...|:.|...:::
Human   137 ALTHNAEVPRRRAQEAEEAGAA------------LRTARAGYRGRALDYALQINVIEDKRKFDIM 189

  Fly   219 QHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEI-----KQKQD-EDRRSLLDLRTVLRST 277
            :.::....|.:.:|:.|.:.:.....|..:|..:||::     ::|:| |.|..||..:.:....
Human   190 EFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQLHQLVLNSAREKRDMEQRHVLLKQKELGGEE 254

  Fly   278 PDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGHLLKKSEGKVRRVWQKRRCRVTSDGFL 342
            |:       ||.....|               |:..:|||.|::.... :.|.:|...:.|:
Human   255 PE-------PSLREGPG---------------GLVMEGHLFKRASNAF-KTWSRRWFTIQSN--- 293

  Fly   343 DIFHADESKPPTRV---NLLTCQIKPVPDDKRG--FDLISYNRPYHFQAEDEGDQKAWMAVLVNC 402
            .:.:..:.|.|..|   :|..|.:|..||.:|.  |:::|.::....||:.|...:.|    |:.
Human   294 QLVYQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLW----VSA 354

  Fly   403 KEKALTKAFQHANPQMSP-------------SLVELQK-------------TVIRYVQLLPGNDR 441
            .:.::..||..|....||             |...|..             .|:..||.:.||.:
Human   355 VQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATLGSGGMARGREPGGVGHVVAQVQSVDGNAQ 419

  Fly   442 CCDCGSRNDV-TWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLN 505
            ||||  |... .|.|:|.|:.:||||||:||.||||.|:::|||||:.....:.:...:||..:|
Human   420 CCDC--REPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIIN 482

  Fly   506 DIMEAK---LGRGKLQHESSMEERYDFIRAKYVAKRYVMRTCS---------------------- 545
            .|.||:   :...|.....|.:|:..:|.||||.|:::.:...
Human   483 QIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGRPRGQPPVPPKPS 547

  Fly   546 ---DDNDLRCDLEQAVVNADMSQL-------------------LQVWAEGADLTCCLPSSDAGET 588
               ....||...|..  :.|:..|                   ....|.|||:...    :.|:.
Human   548 IRPRPGSLRSKPEPP--SEDLGSLHPGALLFRASGHPPSLPTMADALAHGADVNWV----NGGQD 606

  Fly   589 ALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCAL-HDRRECMKLLL 652
            .....:.....::|...:||:||    |.|  .|.|   |..|:....|...| |....|  |.|
Human   607 NATPLIQATAANSLLACEFLLQN----GAN--VNQA---DSAGRGPLHHATILGHTGLAC--LFL 660

  Fly   653 RSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGSTDFSDDE 717
            :.|||...::|:.:..|.||.|..:.....|:..|..||..|               :...:.||
Human   661 KRGADLGARDSEGRDPLTIAMETANADIVTLLRLAKMREAEA---------------AQGQAGDE 710

  Fly   718 TVIDERKSRSRPPSFAGGDSPVLRSRSS 745
            |.:|    ..|..|....|.|...||.|
Human   711 TYLD----IFRDFSLMASDDPEKLSRRS 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	51/224 (23%)
		PH_ASAP	302..410	CDD:270071	24/112 (21%)
		ArfGap_ASAP	425..541	CDD:350063	48/132 (36%)
		Ank_2	554..662	CDD:403870	28/127 (22%)
		ANK repeat	586..622	CDD:293786	8/35 (23%)
		ANK repeat	624..662	CDD:293786	12/38 (32%)
		Ank_2	636..>693	CDD:403870	18/57 (32%)
		SH3_ASAP	1095..1149	CDD:212755
ACAP1	NP_055531.1	Required for formation of endosomal tubules when overexpressed with PIP5K1C	1..382		93/416 (22%)
		BAR	18..217	CDD:299863	50/221 (23%)
		PH	266..360	CDD:278594	23/101 (23%)
		PH_ACAP	268..364	CDD:270070	24/103 (23%)
		Required for interaction with GULP1	405..740		98/368 (27%)
		ArfGap	406..519	CDD:279720	47/114 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..581		5/57 (9%)
		Prevents interaction with ITGB1 when S-554 is not phosphorylated	525..566		3/42 (7%)
		ANK	<592..692	CDD:238125	30/114 (26%)
		ANK repeat	606..637	CDD:293786	9/39 (23%)
		Ank_5	626..680	CDD:290568	20/64 (31%)
		ANK repeat	639..670	CDD:293786	10/32 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820