DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and ASAP2

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_011508705.1	Gene:	ASAP2 / 8853	HGNCID:	2721	Length:	1020	Species:	Homo sapiens

Alignment Length:	1188	Identity:	477/1188 - (40%)
Similarity:	642/1188 - (54%)	Gaps:	204/1188 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSLIAVSEFVEETRSDYSSPTTSTFASRMPDCRHTIGVLEE-----------RLEFDREGLTKLK 56
            |..|:|||||.||..||.:||.|:|.:|...||:|:..:||           .|:.||..|.|:|
Human     2 PDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEVRRPARRLRPQALDVDRMVLYKMK 66

  Fly    57 KAVKAIHNSGNTHVDNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNIN 121
            |:||||::||..||:||....:|||:.||..:.:|:||:|:|||||||.||||:||.|.|:||:|
Human    67 KSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN 131

  Fly   122 NIVMFPVDSMLKSELRGVKGDMKRPFDKAAKDYEAKFIKIEKEKKAQAKEAGMVRTEIDAAVVAE 186
            ||:.||:||:||.:|:|||||:|:|||||.||||.|..|||||||..||..||:||||..|.:||
Human   132 NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISGAEIAE 196

  Fly   187 EMEKERRLYQLQTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSE 251
            |||||||.:|||.||||||..:||.|.|::|||:||:|:||..|:|:|||:.:|.....|..||.
Human   197 EMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLST 261

  Fly   252 KLHEIKQKQDEDRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTRQGH 316
            .||.|||.|||:||.|:.||.:|:|....|:.::...|:.|...| |||||.||:|.||..|.|.
Human   262 DLHTIKQAQDEERRQLIQLRDILKSALQVEQKESRRDSQIRQSTA-YSLHQPQGNKEHGTERNGS 325

  Fly   317 LLKKSEGKVRRVWQKRRCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPDDKRGFDLISYNRP 381
            |.|||:| :|:|||||:|.| .:|||.|.|...::||.::||||||:|..|::|:.|||||::|.
Human   326 LYKKSDG-IRKVWQKRKCSV-KNGFLTISHGTANRPPAKLNLLTCQVKTNPEEKKCFDLISHDRT 388

  Fly   382 YHFQAEDEGDQKAWMAVLVNCKEKALTKAFQHANPQMSPSLV-ELQKTVIRYVQLLPGNDRCCDC 445
            ||||||||.:.:.||:||.|.||:||..||:..:.....::| ||.|.:|..||.:.|||.||||
Human   389 YHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDC 453

  Fly   446 GSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEA 510
            |: .|.||:|.|.|||.||:|||:||:||||:||:||||||.|.|:.||:|:.:||:..|:|||.
Human   454 GA-PDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMEC 517

  Fly   511 KL---GRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAE 572
            .|   ...|....|.|..|.|:|.|||:.:||..:..:|:......|.:||...|:..|||.:|:
Human   518 CLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCEAVKTRDIFGLLQAYAD 582

  Fly   573 GADLTCCLP---SSDAGETALHLAVLREMGSTLHIVDFLIQNMPPKGLNKATNPAGLLD-VTGK- 632
            |.|||..:|   ..:..||||||||.....::|||||||:||            :|.|| .|||
Human   583 GVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQN------------SGNLDKQTGKG 635

  Fly   633 NTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAFDH 697
            :||||.|.|.|..||:|||||..|..|:.|...:|.|||||.:.|..|.||:..|:....::..|
Human   636 STALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVH 700

  Fly   698 INTDWNLPNEDGSTDFSDDETVIDER------KSRSRPPSFAGGDSPVLRSRSSTCDSIQSSSSP 756
            :..:|.|.:||  .|.|||:  :||:      :...||.||....|..|:|.:.   |:...::.
Human   701 VEYEWRLLHED--LDESDDD--MDEKLQPSPNRREDRPISFYQLGSNQLQSNAV---SLARDAAN 758

  Fly   757 IANCPSRQFTLPSGLPSYTHSAGTSPKQHISVGQYLGSATNVGGNGPGNGGSSPSSASSQSVRAA 821
            :|....|.| :||.|.:.|:.|..|                  |:.|....::||:.|
Human   759 LAKEKQRAF-MPSILQNETYGALLS------------------GSPPPAQPAAPSTTS------- 797

  Fly   822 RNSLNMQSDLGGHVTGARKSTSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPRHSQNFD 886
                                             ||..||..:|...::|...||
Human   798 ---------------------------------APPLPPRNVGKVQTASSANTL----------- 818

  Fly   887 ASDIRAINHKNQSLDVAYGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNNSLMPAMTTFGH 951
                    .|..|:.|                 .||.....|.||    ...:..|.|...|..:
Human   819 --------WKTNSVSV-----------------DGGSRQRSSSDP----PAVHPPLPPLRVTSTN 854

  Fly   952 KRSPSGESLNRNIHLAGAKLVLPPTGELPTLKHVDKSALTRPKIP-PPG------PPSEREISNG 1009
            ..:|:..               ||..:.|::    ..||::|..| |||      ||.
Human   855 PLTPTPP---------------PPVAKTPSV----MEALSQPSKPAPPGISQIRPPPL------- 893

  Fly  1010 QSNESISSMDEGPVAPPRKLVNQS-ANFPDYESWHTDMDSSGGGLDHSAESNVSSSDNDRLNSSP 1073
                        |..||.:|..:. |...|..:..|:.....|.:|.||...:....|..:...|
Human   894 ------------PPQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPP 946

  Fly  1074 -DNPSKTGGAGLGGKFHYNGQRRCRALYDCVADNDDELEFKEGEILIVLNERTDDENWMEGIIEG 1137
             ..|.|:....|..|       |.:|||:|||||.|||.|.||:::||..|  :|:.|..|.|:|
Human   947 APMPRKSQATKLKPK-------RVKALYNCVADNPDELTFSEGDVIIVDGE--EDQEWWIGHIDG 1002

  Fly  1138 QPTRKGMFPVSFVHMLPD 1155
            .|.|||.|||||||.:.|
Human  1003 DPGRKGAFPVSFVHFIAD 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	126/224 (56%)
		PH_ASAP	302..410	CDD:270071	60/107 (56%)
		ArfGap_ASAP	425..541	CDD:350063	63/118 (53%)
		Ank_2	554..662	CDD:403870	52/112 (46%)
		ANK repeat	586..622	CDD:293786	17/35 (49%)
		ANK repeat	624..662	CDD:293786	22/39 (56%)
		Ank_2	636..>693	CDD:403870	26/56 (46%)
		SH3_ASAP	1095..1149	CDD:212755	30/53 (57%)
ASAP2	XP_011508705.1	BAR	34..259	CDD:299863	126/224 (56%)
		PH_ASAP	311..417	CDD:270071	60/107 (56%)
		PH	320..407	CDD:278594	48/88 (55%)
		ArfGap	435..552	CDD:279720	62/117 (53%)
		ANK repeat	564..596	CDD:293786	13/31 (42%)
		ANK	<593..687	CDD:238125	49/105 (47%)
		ANK repeat	600..632	CDD:293786	20/43 (47%)
		Ank_5	621..675	CDD:290568	29/65 (45%)
		ANK repeat	634..665	CDD:293786	17/30 (57%)
		SH3_ASAP2	962..1017	CDD:212899	33/56 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1622
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	760	1.000	Inparanoid score	I551
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50059
OrthoDB	1	1.010	-	-		D218818at33208
OrthoFinder	1	1.000	-	-		FOG0002646
OrthoInspector	1	1.000	-	-		otm41395
orthoMCL	1	0.900	-	-		OOG6_102461
Panther	1	1.100	-	-	O	PTHR45854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10447
SonicParanoid	1	1.000	-	-		X1370
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870