DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asap and smap1

DIOPT Version :9

Sequence 1:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_021336343.1	Gene:	smap1 / 777731	ZFINID:	ZDB-GENE-060920-2	Length:	483	Species:	Danio rerio

Alignment Length:	664	Identity:	142/664 - (21%)
Similarity:	217/664 - (32%)	Gaps:	238/664 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 KEKALTKAFQHANPQMSPSLVELQKTVIRYVQLLPGNDRCCDCGSRNDVTWISLNFGILVCIQCS 467
            :|||     |..|.|....|.::.:.        ..|..|.||.::.. .|.|.|.|:.:||:|:
Zfish     7 REKA-----QKLNEQHQAILSKMLRE--------DDNKYCADCEAKGP-RWASWNLGVFICIRCA 57

  Fly   468 GVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNSTLNDIMEAKLGRGKLQHESSMEERYDFIRA 532
            |:||:||||.||::|:.||..|...:...::|||:....:.||.|.....:.::.....: |||.
Zfish    58 GIHRNLGVHISRVKSVNLDQWTPEQIQSVQSMGNTKARQLYEAHLPENFRRPQTDQAVEF-FIRD 121

  Fly   533 KYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQLLQVWAEGADLTCCLPSSDAGETALHLAVLRE 597
            ||..|:|.     |.|.:                     .||     :.||||
Zfish   122 KYERKKYY-----DKNSV---------------------NGA-----IKSSDA------------ 143

  Fly   598 MGSTLHIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKN 662
                              .|...::|:        :.|.....|...||              |.
Zfish   144 ------------------ALPSVSSPS--------SQAAEKSKLEKERE--------------KK 168

  Fly   663 SQNKTALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGSTDFSDDETVIDERKS-- 725
            .:.|                      ||||        |.:..|:....:...::..||.|.|
Zfish   169 KEEK----------------------KREK--------DTDKENKPAVLEKKREDNQIDSRISPK 203

  Fly   726 RSRPPS--FAGGDSPVLRSRSSTCDSIQSSSSPIAN-----CPSRQFTLPSGLPS--YTHSAGTS 781
            :|..|:  ..|.|:|.:.|.||...:  ||::||::     .|.....|||...|  .:.|....
Zfish   204 KSAEPAIDLLGLDAPTVGSASSGAGT--SSAAPISDDLDIFGPMVSNPLPSNSNSSQVSSSKAAG 266

  Fly   782 PKQHISVGQYLGSATNVGGNGPGNGG---SSPSSASSQSVRAARNSLNMQSDL---GGHVTGARK 840
            ..|..|.|..:..||..|...|..|.   .|.:|.:|::..:|:..|:..|.|   |......:.
Zfish   267 SAQASSAGGAVAGATGTGSAAPAQGDLDLFSETSGNSKAEDSAKKPLSKDSILSLYGSSTVPQQP 331

  Fly   841 STSTANMNSLKKRTAPAPPPGTLGSASSSSFYGTLPHPPRHSQNFDASDIRAINHKNQSLDVAYG 905
            :.:||......:...||.|.|                      ||            |:.....|
Zfish   332 AQATAMFMGPSQMQFPAQPQG----------------------NF------------QAFPGMGG 362

  Fly   906 TLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNNSLMPAMTTFGHKRSPSGESLNRNIHLAG-A 969
            .:|....:            |.....||:..|.|..:|..||      .|:|...|....:.| |
Zfish   363 AMPPTTMM------------GAVMGQGGAMMGQNTGMMVGMT------MPNGFMGNAQPGVMGLA 409

  Fly   970 KLVLPPTGELPTLKHVDKSALTRPKIPPPG-----PPSEREISNGQSNESISSMD---------- 1019
            ..::.|.|                .:||..     |..:.:.:..|.|:.:|.|:
Zfish   410 PGMMGPQG----------------MVPPQNMYAMQPGQQGQWNMAQINQQMSGMNLNGSGAPMAF 458

  Fly  1020 -------EGPVAPP 1026
                   .|.||||
Zfish   459 GQPGAPMGGWVAPP 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071	3/6 (50%)
		ArfGap_ASAP	425..541	CDD:350063	37/115 (32%)
		Ank_2	554..662	CDD:403870	12/107 (11%)
		ANK repeat	586..622	CDD:293786	1/35 (3%)
		ANK repeat	624..662	CDD:293786	4/37 (11%)
		Ank_2	636..>693	CDD:403870	8/56 (14%)
		SH3_ASAP	1095..1149	CDD:212755
smap1	XP_021336343.1	ArfGap	18..132	CDD:307528	39/128 (30%)
smap1	XP_021336343.1	Med15	<329..>466	CDD:312941	33/204 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900